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Top Kid friendly Southeast Missouri Hotels

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

4 hours drive from Mark Twain National Forest

Stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in ...

Best Western Plus Sikeston I-55

120 S Interstate Drive Sikeston MO

4 hours drive from Mark Twain National Forest

Stay at this hotel in Sikeston. Enjoy free breakfast, free parking and a fitness centre. Our guests praise the breakfast and the helpful staff in their reviews. ...

8.4/10 Very good! (1,005 reviews)

"It looked better in the pictures. I would not stay there again until they renovate the place. The breakfast was not great coffee was lukewarm. No charging outlets in the rooms at all. It was like going back to the 80’s . The staff was very nice though."

Reviewed on 26 Oct 2026

Drury Inn & Suites Cape Girardeau

3303 Campster Drive Cape Girardeau MO

5 hours drive from Mark Twain National Forest

Stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean ...

9.4/10 Exceptional! (1,000 reviews)

"Clean and tidy, friendly staff. Pet friendly. Easy access from the highway. In and out with a good night's sleep and no hassle"

Reviewed on 27 Oct 2026

See all 698 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.