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Top Kid friendly Southeast Missouri Hotels

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner, Sikeston, MO

4 hours drive from Mark Twain National Forest

Stay at this 3-star business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...

9.4/10 Exceptional! (1,006 reviews)

Everyone was friendly and polite. Great stay and staff…..

Reviewed on 9 Nov 2025

Pear Tree Inn Sikeston

2602 E Malone Avenue, Sikeston, MO

4 hours drive from Mark Twain National Forest

Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...

9.2/10 Wonderful! (1,003 reviews)

Everything was clean, staff was friendly

Reviewed on 9 Nov 2025

Best Western Plus Sikeston

120 S Interstate Drive, Sikeston, MO

4 hours drive from Mark Twain National Forest

Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...

8.2/10 Very Good! (1,014 reviews)

Good place to stay in Sikestn

All good here

Reviewed on 26 Oct 2025

See all 605 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.