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Top Kid friendly Southeast Missouri Hotels

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

4 hours drive from Mark Twain National Forest

Stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in ...

9.4/10 Exceptional! (1,000 reviews)

The room was very nice and the bathroom was very clean. Everything was very nice and the breakfast was good. We were very pleased with everything. I recommend it highly.

Reviewed on 2 Jan 2026

Pear Tree Inn Sikeston

2602 E Malone Avenue Sikeston MO

4 hours drive from Mark Twain National Forest

Stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free Wi-Fi and a fitness centre. Our guests praise the breakfast and the helpful staff ...

9.2/10 Wonderful! (1,000 reviews)

Clean and comfy room. Great staff

Reviewed on 6 Jan 2026

Best Western Plus Sikeston

120 S Interstate Drive Sikeston MO

4 hours drive from Mark Twain National Forest

Stay at this hotel in Sikeston. Enjoy free breakfast, free parking and a fitness centre. Our guests praise the breakfast and the helpful staff in their reviews. ...

8.2/10 Very Good! (1,005 reviews)

Everything was very good from entering to exiting.

Reviewed on 3 Jan 2026

See all 623 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.