Top Kid friendly Southeast Missouri Hotels

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner, Sikeston, MO

4 hours drive from Mark Twain National Forest

Stay at this 3-star business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...

9.4/10 Exceptional! (1,001 reviews)

"Excellent as always."

Reviewed on 6 Aug. 2025

Pear Tree Inn Sikeston

2602 E Malone Avenue, Sikeston, MO

4 hours drive from Mark Twain National Forest

Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...

9.2/10 Wonderful! (1,000 reviews)

Best place in the area

"Amazing hotel. My favorite in the area. Friendly staff, clean and comfy. Very welcoming. Great snacks in the evening and breakfast in the morning."

Reviewed on 4 Aug. 2025

Best Western Plus Sikeston

120 S Interstate Drive, Sikeston, MO

4 hours drive from Mark Twain National Forest

Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...

8.2/10 Very Good! (1,006 reviews)

Nice staff

"Hotel was old but in decent condition. Toilets were extremely low even when I viewed a disabled unit. Beds were not very comfortable. Food options were good but only had no sugar syrup. juice was watered down and not very flavorful. Overall, staff were not and accommodating in spite of the hotel ..."

Reviewed on 5 Aug. 2025

See all 589 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.