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Top Honeymoon Southeast Minnesota Hotels

Alexander Mansion Bed and Breakfast

274 East Broadway Winona MN

2 hours drive from Mayo Clinic

Stay at this B&B in Winona. Enjoy free breakfast, free parking and a business centre. Popular attractions Watkins Heritage Museum and Polish Cultural Institute ...

10/10 Exceptional! (366 reviews)

Room was great, the breakfast was the best ever. B&B here should stand for Best/Breakfast. Richard puts on a awesome breakfast. Going to definitely go back!

Reviewed on 18 Jan 2026

Residence Inn by Marriott Rochester Mayo Clinic Area

441 W Center St Nw Rochester MN

4 min walk from Mayo Clinic

Stay at this hotel in Rochester. Enjoy free breakfast, free Wi-Fi and a rooftop terrace. Our guests praise the helpful staff in their reviews. Popular attractions ...

8.4/10 Very Good! (201 reviews)

We were there for 3 nights while visiting Doctors at Mayo. The location is very good and is connected to the Mayo Subway. The hotel was clean and staff friendly.

Reviewed on 14 Jan 2026

St James Hotel, a Historic Hotel of America

406 Main St. Red Wing MN

2 hours drive from Mayo Clinic

Stay at this 3.5-star spa hotel in Red Wing. Enjoy free Wi-Fi, free parking and a full-service spa. Our guests praise the helpful staff and the comfy rooms in ...

9.2/10 Wonderful! (1,000 reviews)

We checked in on Christmas Day 2025 and stayed 1 night. The hotel is in the heart of beautiful downtown Red Wing, MN. The hotel was beautifully decorated for the holidays and was warm and inviting. We had brunch at the beautiful Scarlet Kitchen and Bar and the food and service could not have been ...

Reviewed on 5 Jan 2026

See all 941 properties in Southeast Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.