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Top Honeymoon Southeast Minnesota Hotels

Alexander Mansion Bed and Breakfast

274 East Broadway Winona MN

2 hours drive from Mayo Clinic

Stay at this B&B in Winona. Enjoy free parking, a business centre and daily housekeeping. Popular attractions Winona Arts Center and Watkins Heritage Museum ...

9.8/10 Exceptional! (498 reviews)

n/a - the rooms do not have kitchens. The main kitchen is used by the owner to prepare breakfast.

Reviewed on 13 Apr 2026

Residence Inn by Marriott Rochester Mayo Clinic Area

441 W Center St Nw Rochester MN

4 min walk from Mayo Clinic

Stay at this hotel in Rochester. Enjoy free breakfast, free Wi-Fi and a rooftop terrace. Our guests praise the helpful staff in their reviews. Popular attractions ...

8.4/10 Very Good! (206 reviews)

Great breakfast, friendly staff, subway level to Mayo was so helpful

Reviewed on 19 Mar 2026

St James Hotel, a Historic Hotel of America

406 Main St. Red Wing MN

2 hours drive from Mayo Clinic

Stay at this spa hotel in Red Wing. Enjoy free Wi-Fi, free parking and a full-service spa. Our guests praise the helpful staff and the comfy rooms in their reviews. ...

9.2/10 Wonderful! (1,000 reviews)

Great historical location with great lobby’s and lounges and food on site. Downtown area was nice with stores and restaurants nearby

Reviewed on 19 Apr 2026

See all 947 properties in Southeast Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.