Southeast Missouri Adventure Holidays 2026

Photo by JG Morris

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Top Adventure Southeast Missouri Hotels

Hampton Inn Farmington

850 Valley Creek Dr Farmington MO

2 hours drive from Mark Twain National Forest

Stay at this hotel in Farmington. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff in their reviews. Popular attractions ...

Crown Pointe Lodge, BW Signature Collection

4245 Hunt Rd Farmington MO

2 hours drive from Mark Twain National Forest

Stay at this golf hotel in Farmington. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff in their reviews. Popular attractions ...

9/10 Wonderful! (665 reviews)

"It didn’t seem very clean. There were stains on the sheets. The bed was uncomfortable and the breakfast was not very good. I would not stay there again."

Reviewed on 15 Aug 2026

Echo Bluff State Park

34489 Echo Bluff Dr Eminence MO

43 min drive from Mark Twain National Forest

Stay at this business-friendly hotel in Eminence. Enjoy free Wi-Fi, free parking and a 24-hour front desk. Popular attractions Echo Bluff State Park and Current ...

See all 671 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.