A forested valley with autumn foliage, a rocky cliff, and a sunset.

Business Hotels & Resorts in Southern Illinois from NZ$135

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Check availability on Southern Illinois Business Hotels

Tonight
8 Oct - 9 Oct
Tomorrow
9 Oct - 10 Oct
This weekend
9 Oct - 11 Oct
Next weekend
16 Oct - 18 Oct

Our top choices for Southern Illinois business-friendly hotels

A bar area with a long counter, multiple chairs, and hanging light fixtures.
A hotel lobby with a Kitchen+Bar area, seating arrangements, and a view to the outside.
An indoor swimming pool with a metal ladder, a warning sign about cold weather, and a view of the outside.
A spacious lobby with a reception desk, seating area, and glass doors leading outside.

1. Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon
Mount Vernon
United States
Susan
NZ$223
includes taxes & fees
18 Oct - 19 Oct
Drury Plaza Hotel Mt. Vernon
A Holiday Inn Express & Suites building with a modern design, featuring a covered entrance and illuminated pillars.
A modern kitchen with a wooden cabinet, coffee maker, and storage shelves.
An indoor swimming pool with clear lane markings, a lifeguard chair, and a window providing natural light.
A hotel room with two beds, a large window, and a wall-mounted lamp.

2. Holiday Inn Express & Suites Mount Vernon by IHG

Holiday Inn Express & Suites Mount Vernon by IHG
Mount Vernon
United States
John
NZ$224
includes taxes & fees
8 Nov - 9 Nov
Holiday Inn Express & Suites Mount Vernon by IHG
A hotel lobby with a reception desk, seating area, and a large screen TV.
A hotel room with a marble bathtub, a wooden dining table with chairs, a bed with a headboard, and a nightstand with lamps.
A Comfort Suites hotel with a spacious parking lot and a modern brick facade.
A hotel dining area with a large wooden table, red upholstered chairs, a flat-screen TV mounted above the fireplace, and a kitchen area in the background.

3. Comfort Suites Mount Vernon

Comfort Suites Mount Vernon
Mount Vernon
United States
Lori
NZ$245
includes taxes & fees
11 Oct - 12 Oct
Comfort Suites Mount Vernon
A spacious lobby with a stone fireplace, a seating area with a sofa and chairs, and a television mounted on the wall.
A hallway with vending machines and a carpeted floor.
A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.
A hotel with a flat facade, multiple windows, and a sign indicating it is a 'SureStay Hotel by Best Western'.

4. SureStay Hotel by Best Western Whittington Rend Lake

SureStay Hotel by Best Western Whittington Rend Lake
Whittington
United States
MARK
NZ$169
includes taxes & fees
19 Oct - 20 Oct
SureStay Hotel by Best Western Whittington Rend Lake
A modern living room with a fireplace, a bookshelf, a large wall clock, and a cozy seating area.
A Country Inn & Suites building with a covered entrance and a parking lot.
A modern living room with a sofa, coffee table, and a dining area with chairs.
An indoor swimming pool with clear water, surrounded by white lounge chairs and tables, with a high ceiling and natural light from windows.

5. Country Inn & Suites by Radisson, Marion, IL

Country Inn & Suites by Radisson, Marion, IL
Marion
United States
Lisa
NZ$178
includes taxes & fees
8 Nov - 9 Nov
Country Inn & Suites by Radisson, Marion, IL
An indoor swimming pool with a clear view of the surrounding area, including a seating area with chairs and a view of the outdoors through large windows.
A spacious dining area with a long wooden table, multiple chairs, and pendant lighting.
A hotel room with a large bed, two bedside tables with lamps, a desk with a chair, a television, and a framed artwork on the wall.
A hotel room with a desk, two monitors, a keyboard, and a mouse.

6. Best Western Delta Inn

Best Western Delta Inn
Effingham
United States
Susan
NZ$166
includes taxes & fees
25 Oct - 26 Oct
Best Western Delta Inn
A La Quinta hotel with a stone facade, a covered entrance, and a parking lot.
A modern kitchen area with a counter, various appliances, and food display items.
A hotel room with a large bed, a desk with a chair, a flat-screen TV, a bathtub, and framed pictures on the wall.
A modern hotel lobby with a large sun-shaped artwork, multiple seating areas, and a patterned rug.

7. La Quinta Inn & Suites by Wyndham Effingham

La Quinta Inn & Suites by Wyndham Effingham
Effingham
United States
Sarah
NZ$236
includes taxes & fees
8 Nov - 9 Nov
La Quinta Inn & Suites by Wyndham Effingham
A modern spa room with a large hot tub, a glass wall with a reflective pattern, and a ceiling with a skylight.
A casino interior with slot machines, a large chandelier, and a carpeted floor.
A hotel lobby with a marble floor, a reception area with a '12 & VINE' sign, and a dining area with orange chairs and chandeliers.
A hotel lobby with a marble floor, a reception desk, a sign for 'Restrooms', and a large chandelier.

8. Walker's Bluff Casino Resort

Walker's Bluff Casino Resort
Carterville
United States
Michael
NZ$222
includes taxes & fees
12 Oct - 13 Oct
Walker's Bluff Casino Resort
An outdoor patio with stone fire pit, colorful striped sofas, and blue chairs.
A hotel reception area with a wooden reception desk, a digital kiosk, and a refrigerated display case with beverages.
A spacious lobby with a central seating area, a large window, and a reception desk.
A modern kitchen with a stainless steel refrigerator, microwave, and dishwasher. There is a window providing natural light and a view of the outdoors.

9. Home2 Suites by Hilton Carbondale

Home2 Suites by Hilton Carbondale
Carbondale
United States
Alyssa
NZ$210
includes taxes & fees
1 Nov - 2 Nov
Home2 Suites by Hilton Carbondale
A spacious lobby with a patterned carpet, a fireplace, seating area, and a staircase.
A hotel room with two beds, a desk, and a chair.
A spacious lobby with a patterned carpet, a staircase, a fireplace, and seating areas.
A breakfast area with wooden cabinets, a coffee machine, a toaster, and a sign reading "Breakfast Corner".

10. Baymont by Wyndham Marion

Baymont by Wyndham Marion
Marion
United States
Frank
NZ$182
includes taxes & fees
11 Oct - 12 Oct
Baymont by Wyndham Marion
View all properties

Top Southern Illinois Hotel Reviews

Holiday Inn Express Metropolis by IHG

Holiday Inn Express Metropolis by IHG

10/10 Excellent
"Great hotel! Lovely staff, spacious room, and my husband liked the breakfast so much we drove an extra 1.5 hours just to stay there again on our return trip!"
Rachael 1-night trip
Posted 13 hours ago
Holiday Inn Express Metropolis by IHG
Comfort Suites Mount Vernon

Comfort Suites Mount Vernon

8/10 Good
"The front desk staff Kim is very helpful and accommodating, she’s a hard worker too, we had good service from Kim"
Cristino 1-night trip
Posted 2 days ago
Comfort Suites Mount Vernon
Drury Inn & Suites Marion

Drury Inn & Suites Marion

8/10 Good
"friendly and helpful staff. Great food with many options to choose from. Great hot tub"
Carolyn 1-night trip
Posted 3 days ago
Drury Inn & Suites Marion
Comfort Inn Edwardsville - St. Louis

Comfort Inn Edwardsville - St. Louis

10/10 Excellent
"Nice location."
James 4-night trip
Posted 4 days ago
Comfort Inn Edwardsville - St. Louis
Quality Inn & Suites Metropolis I-24

Quality Inn & Suites Metropolis I-24

8/10 Good
"Motel is close to the interstate and has a bar and grill next door. Staff was very pleasant and helpful. Lobby and room were clean and neat. The hallway to the room had a musty mildew smell to it. Shower pressure was adequate but weak. TV and Air conditioning were both working well."
Paul 1-night trip
Posted 8 days ago
Quality Inn & Suites Metropolis I-24
Country Inn & Suites by Radisson, Marion, IL

Country Inn & Suites by Radisson, Marion, IL

10/10 Excellent
"This is an excellent hotel to stay at. Updated, easy parking, staff is very friendly, breakfast is great, will stay at this hotel again."
Lisa 3-night trip
Posted 11 days ago
Country Inn & Suites by Radisson, Marion, IL

Frequently asked questions

How much do business-friendly hotels in Southern Illinois cost?
You'll pay between NZ$135 and NZ$236 per night for business-friendly hotels in Southern Illinois. Awesome deals on stays that cater to work-related travellers are just a few clicks away on Expedia. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
How many business-friendly hotels are there in Southern Illinois?
Take your pick of 149 business-friendly hotels in Southern Illinois. When you need to get down to work, Expedia can help you secure the ideal space with the amenities you're after.
What is there to do in Southern Illinois near my business-friendly hotel?
You'll find tons of attractions to see during your travels through Southern Illinois. If you've planned a few days in Murphysboro, Lake Murphysboro State Park is popular with visitors.

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