Photo by Southernmost Illinois Tourism Bureau

Business Hotels & Resorts in Southern Illinois from NZ$123

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Check availability on Southern Illinois Business Hotels

Tonight
8 Dec - 9 Dec
Tomorrow
9 Dec - 10 Dec
This weekend
12 Dec - 14 Dec
Next weekend
19 Dec - 21 Dec

Best Southern Illinois Business Hotels

Exterior
Drury Inn & Suites Marion

Drury Inn & Suites Marion

3.0 star property
Marion
9.4 out of 10, Exceptional, (1000)
"Great hotel and very clean "
United States
Jose
The price is NZ$135
includes taxes & fees
2 Jan - 3 Jan 2026
Drury Inn & Suites Marion
Terrace/patio
Comfort Suites Mount Vernon

Comfort Suites Mount Vernon

2.5 star property
Mount Vernon
9.0 out of 10, Wonderful, (1008)
"Rooms have been painted great breakfast close to interstate and restaurants"
United States
Stephen
The price is NZ$213
includes taxes & fees
9 Dec - 10 Dec
Comfort Suites Mount Vernon
Free daily buffet breakfast
Holiday Inn Express Hotel & Suites Marion Northeast by IHG

Holiday Inn Express Hotel & Suites Marion Northeast by IHG

2.5 star property
Marion
9.0 out of 10, Wonderful, (925)
"yes the room was great and the staff was great! "
United States
Amador
The price is NZ$202
includes taxes & fees
2 Jan - 3 Jan 2026
Holiday Inn Express Hotel & Suites Marion Northeast by IHG
Lobby
Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

3.0 star property
Mount Vernon
9.6 out of 10, Exceptional, (1566)
"Great place to stay. Check in is easy and the hotel people are very nice."
United States
Duane
The price is NZ$184
includes taxes & fees
14 Dec - 15 Dec
Drury Plaza Hotel Mt. Vernon
Room, 1 Queen Bed, Accessible, Non Smoking
Super 8 by Wyndham Mt. Vernon IL

Super 8 by Wyndham Mt. Vernon IL

2.5 star property
Mount Vernon
7.8 out of 10, Good, (1003)
"Clean comfortable room and bed. Great location to many restaurants and shopping. "
United States
Patricia
The price is NZ$123
includes taxes & fees
4 Jan - 5 Jan 2026
Super 8 by Wyndham Mt. Vernon IL
Lobby
La Quinta Inn & Suites by Wyndham Effingham

La Quinta Inn & Suites by Wyndham Effingham

3.0 star property
Effingham
9.2 out of 10, Wonderful, (1005)
"Clean room, excellent location, pet friendly. Would definitely book again. "
United States
Misty
The price is NZ$180
includes taxes & fees
21 Dec - 22 Dec
La Quinta Inn & Suites by Wyndham Effingham
Lobby
SureStay Hotel by Best Western Whittington Rend Lake

SureStay Hotel by Best Western Whittington Rend Lake

2.5 star property
Whittington
8.8 out of 10, Excellent, (903)
"Great place to stay."
United States
Stephen
The price is NZ$139
includes taxes & fees
31 Dec - 1 Jan 2026
SureStay Hotel by Best Western Whittington Rend Lake
Room, 2 Queen Beds, Non Smoking
Country Inn & Suites by Radisson, Effingham, IL

Country Inn & Suites by Radisson, Effingham, IL

2.5 star property
Effingham
8.8 out of 10, Excellent, (1000)
"Clean rooms and kind staff"
United States
Linda
The price is NZ$180
includes taxes & fees
29 Dec - 30 Dec
Country Inn & Suites by Radisson, Effingham, IL
Reception
Best Western Plus Centralia Hotel & Suites

Best Western Plus Centralia Hotel & Suites

2.5 star property
Centralia
9.6 out of 10, Exceptional, (598)
"Very beautiful place to stay "
United States
Valerie
The price is NZ$234
includes taxes & fees
1 Jan - 2 Jan 2026
Best Western Plus Centralia Hotel & Suites
Free daily continental breakfast
Best Western Delta Inn

Best Western Delta Inn

2.5 star property
Effingham
9.2 out of 10, Wonderful, (1002)
"Clean room, courteous staff, nice amenities."
United States
Richard M
The price is NZ$163
includes taxes & fees
6 Jan - 7 Jan 2026
Best Western Delta Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Southern Illinois Hotel Reviews

Drury Inn & Suites St. Louis O'Fallon, IL

Drury Inn & Suites St. Louis O'Fallon, IL

10/10 Excellent
"Nedd a bit more variety in alcohol choices - miller lite, wine. also better food choices - absolutely great hardworking friendly staff!"
kathleen 2-night trip
Posted 4 days ago
Drury Inn & Suites St. Louis O'Fallon, IL

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Frequently asked questions

How much do business-friendly hotels in Southern Illinois cost?
You'll pay between NZ$123 and NZ$234 per night for business-friendly hotels in Southern Illinois. Awesome deals on stays that cater to work-related travellers are just a few clicks away on Expedia. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
How many business-friendly hotels are there in Southern Illinois?
Take your pick of 149 business-friendly hotels in Southern Illinois. When you need to get down to work, Expedia can help you secure the ideal space with the amenities you're after.
What is there to do in Southern Illinois near my business-friendly hotel?
You'll find tons of attractions to see during your travels through Southern Illinois. If you've planned a few days in Murphysboro, Lake Murphysboro State Park is popular with visitors.