Photo by Southernmost Illinois Tourism Bureau
Holiday Homes in Southern Illinois
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check prices for these dates
In two weeks
In two months
In three months
In four months
Our top choices for Southern Illinois holiday homes
The Tinley House. Close to hiking, hunting. Bike trail and hospital, shopping
The Tinley House. Close to hiking, hunting. Bike trail and hospital, shoppingHarrisburg
9.8 out of 10, Exceptional, (22)
"Great place to stay"
Neil I.
The price is NZ$291
includes taxes & fees
2 Jan - 3 Jan 2026
Charming 2-bedroom barn-style home nestled on 6 acres in delightful Vienna
Charming 2-bedroom barn-style home nestled on 6 acres in delightful ViennaVienna
10.0 out of 10, Exceptional, (2)
"This was a perfect spot for us. It was cozy and clean!"
Ann M.
The price is NZ$287
includes taxes & fees
5 Jan - 6 Jan 2026
Brickway Retreat
Brickway RetreatMattoon
9.8 out of 10, Exceptional, (41)
"This house was perfect! Very clean, beautifully decorated and very cozy. So many nice extras. Because of bad weather we had to modify our stay and we were very grateful that the hosts were able to accommodate us. We would absolutely stay here again. "
Shari
The price is NZ$309
includes taxes & fees
31 Dec - 1 Jan 2026
Vintage Charmer on Main Street
Vintage Charmer on Main StreetGreenup
10.0 out of 10, Exceptional, (60)
"Looking forward to staying again on our return trip home"
Karen B.
The price is NZ$237
includes taxes & fees
29 Dec - 30 Dec
The Pine Ridge Home by Garden of the Gods in the Shawnee National Forest
The Pine Ridge Home by Garden of the Gods in the Shawnee National ForestHerod
9.8 out of 10, Exceptional, (129)
"Nice place to stay, with plenty of room. We enjoyed the hot tub. We may take some of our family to this location soon."
Anthony S.
The price is NZ$310
includes taxes & fees
30 Dec - 31 Dec
Beautiful location in the secluded woods
Beautiful location in the secluded woodsPomona
10.0 out of 10, Exceptional, (61)
"It was very nice and clean. We really enjoyed staying there. We would love to rent this place again. "
susan B.
The price is NZ$283
includes taxes & fees
12 Jan - 13 Jan 2026
Small House in Pope County Eddyville, IL surrounded by Shawnee National Forest .
Small House in Pope County Eddyville, IL surrounded by Shawnee National Forest .Eddyville
10.0 out of 10, Exceptional, (15)
"Nice place close to walking trails. Great restaurant/bar close by. "
Sandy
The price is NZ$263
includes taxes & fees
4 Jan - 5 Jan 2026
Waterfront 4-Bedroom Pet Friendly Lake House w/ dock for boat, fishing, swimming
Waterfront 4-Bedroom Pet Friendly Lake House w/ dock for boat, fishing, swimmingCreal Springs
10.0 out of 10, Exceptional, (2)
"We had plenty of room for our whole family. Great bathrooms and kitchen with everything you needed. The outdoor space was enjoyable. But of course the sunset on the lake was amazing."
Diana
The price is NZ$773
includes taxes & fees
29 Dec - 30 Dec
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find holiday rentals that suit your style
Cabins
Private holiday homes
Save an average of 15% on thousands of hotels when you're signed in
Top Southern Illinois Hotel Reviews
La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis
10/10 Excellent
Find out more about Southern Illinois
Southern Illinois Holiday Homes information
Number of reviews | 626 |
|---|---|
Accommodation | 386 Holiday Homes |
Lowest Price | NZ$237 |
Highest Price | NZ$816 |
Explore a world of travel with Expedia
- Caravan Parks in Du Quoin
- Motels in Southern Illinois
- Cabin Rentals in Southern Illinois
- Resort in Southern Illinois
- Motels in Sparta
- Lodges in Pomona
- Apartments in Ava
- Motels in Dix
- Cabin Rentals in Wolf Creek
- Motels in Marion
- Cabin Rentals in Benton
- Dix Hotels
- Marion County Hotels
- Christopher Hotels
- Flora Hotels
- Albion Hotels
- Sims Hotels
- Odin Hotels
- Farina Hotels
- Percy Hotels
- Aviston Hotels
- Cisne Hotels
- Tamaroa Hotels
- Centralia Hotels
- Noble Hotels
- Bonnie Hotels
- Elkville Hotels
- Carlyle Hotels
- Harrisburg Hotels
- Ina Hotels
- Johnston City Hotels
- Belle Rive Hotels
- Creal Springs Hotels
- Hotels near Rainbow Ranch Petting Zoo
- Nashville Hotels
- Equality Hotels
- Enfield Hotels
- Carbondale Hotels
- Benton Hotels
- Marion Hotels
- Carterville Hotels
- Galatia Hotels
- Buckner Hotels
- Hotels near Bell Tower Park
- Whittington Hotels
- Wolf Creek Hotels
- Hotels near Lake of Egypt
- Sesser Hotels
- Mount Vernon Hotels
- Fairfield Hotels
- West Frankfort Hotels
- Okawville Hotels
- Patoka Hotels
- Ava Hotels
- New Haven Hotels
- Herrin Hotels
- Sparta Hotels
- Du Quoin Hotels
- Hoyleton Hotels
- Cheap Hotels in Grayville
- Spa Hotels in Carbondale
- Luxury Hotels in Marion
- Pet Friendly Hotels in Mount Vernon
- Hilton Hotels in Whittington
- Marriott Hotels & Resorts in Carterville
- Herald Holidays
- William Jennings Bryan Boyhood Home and Museum
- Herrin Holidays
- Carmi Holidays
- Sih Medical Group
- Heartland Regional Medical Center
- Lake of Egypt
- Christopher Holidays
- Du Quoin Holidays
- King City Square Shopping Center
- Ken Gray Presidential Hall of Fame
- Salem Fairgrounds
- Opdyke Holidays
- Visit West Frankfort
- Visit Johnston City
- Visit Mount Vernon
- Visit Maunie
- Visit Sesser
- Visit Cisne
- Visit Herrin
- Visit Wertenberg
- Visit Wamac
- Car hire in Avis Fort Lauderdale Cruiseport Shuttle-2520 Miami Rd
- Global Rent a Car Rental Cars in Southern Illinois
- Hertz Rental Cars in Southern Illinois
- Dollar Rental Cars in Southern Illinois
- Enterprise Rental Cars in Benton
- Hertz Rental Cars in Southwest Illinois
- Car hire Mount Vernon
- Car hire Carmi