A forested valley with autumn foliage, a rocky cliff, and a sunset.

Holiday Homes in Southern Illinois

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
16 Oct - 18 Oct
In two months
27 Nov - 29 Nov
In three months
25 Dec - 27 Dec
In four months
22 Jan - 24 Jan

Our top choices for Southern Illinois holiday homes

A kitchen with dark cabinets, a white stove, a window with blinds, and a ceiling fan.

1. Pigs Ina Blanket - Minutes from Rend Lake and I-64/I-57

Pigs Ina Blanket - Minutes from Rend Lake and I-64/I-57
Ina
8.8 out of 10, Excellent, (38 reviews)
"Great place. Clean and comfortable!"
United States
Bill M.
The price is NZ$536
includes taxes & fees
11 Oct - 12 Oct
Pigs Ina Blanket - Minutes from Rend Lake and I-64/I-57
A single-story house with a gabled roof, a front porch with a star decoration, and a number '213' on the wall.

2. Lakeside Shady Rest Home Away from Home blocks from Rend Lake and I57/I64

Lakeside Shady Rest Home Away from Home blocks from Rend Lake and I57/I64
Ina
9.8 out of 10, Exceptional, (29 reviews)
"Very clean, host was very helpful, comfortable beds, fishing was great! Would stay again!"
United States
Contina S.
The price is NZ$390
includes taxes & fees
18 Oct - 19 Oct
Lakeside Shady Rest Home Away from Home blocks from Rend Lake and I57/I64
A room with a bed, a sofa, a coffee table, a small table with a book, a mirror, and a window with a view of greenery.

3. Terrific 1-bedroom Loft with Balcony in Mount Vernon. 1.2 mile Hiking trail.

Terrific 1-bedroom Loft with Balcony in Mount Vernon. 1.2 mile Hiking trail.
Mount Vernon
10.0 out of 10, Exceptional, (3 reviews)
"Beautiful property, great experience"
United States
Glenn
The price is NZ$266
includes taxes & fees
19 Oct - 20 Oct
Terrific 1-bedroom Loft with Balcony in Mount Vernon. 1.2 mile Hiking trail.
A green door with a floral wreath and a bear statue.

4. Romantic couples getaway in awesome Bluford with WiFi, Fireplace, and Game Room

Romantic couples getaway in awesome Bluford with WiFi, Fireplace, and Game Room
Bluford
10.0 out of 10, Exceptional, (7 reviews)
"The property was absolutely gorgeous, very clean, exactly as beautiful as the pictures in a quiet nice neighborhood. The host was incredible as well! Highly recommend!"
United States
Brianna W.
The price is NZ$457
includes taxes & fees
4 Oct - 5 Oct
Romantic couples getaway in awesome Bluford with WiFi, Fireplace, and Game Room
A kitchen with dark wooden cabinets, a black range hood, and a tiled floor.

5. Cozy country setting minutes from Rend Lake

Cozy country setting minutes from Rend Lake
Benton
10.0 out of 10, Exceptional, (51 reviews)
"Great place to stay very clean and comfortable "
United States
Thomas M.
The price is NZ$359
includes taxes & fees
5 Oct - 6 Oct
Cozy country setting minutes from Rend Lake
A modern kitchen with a central island, wooden flooring, and a built-in refrigerator.

6. Beautiful home with pool in Wayne City

Beautiful home with pool in Wayne City
Wayne City
10.0 out of 10, Exceptional, (13 reviews)
"Great place to stay!"
United States
Kevin D.
The price is NZ$476
includes taxes & fees
20 Oct - 21 Oct
Beautiful home with pool in Wayne City
A rustic wooden console table with a mirror, a small plant, and a bird figurine.

7. The Tinley House. Close to hiking, hunting. Bike trail and hospital, shopping

The Tinley House. Close to hiking, hunting. Bike trail and hospital, shopping
Harrisburg
9.8 out of 10, Exceptional, (29 reviews)
"It's a great place to stay. Beautiful house. It's close to most restaurants and to Walmart."
United States
Jamie B.
The price is NZ$301
includes taxes & fees
7 Oct - 8 Oct
The Tinley House. Close to hiking, hunting. Bike trail and hospital, shopping
A patio with a stone fire pit, outdoor seating, and a garden area with various plants and flowers.

8. Newly renovated living room

Newly renovated living room
Benton
9.6 out of 10, Exceptional, (41 reviews)
"Very Nice good location"
United States
Gary A.
The price is NZ$637
includes taxes & fees
19 Oct - 20 Oct
Newly renovated living room
A spacious kitchen with a central island, wooden cabinets, and a ceiling fan.

9. Cozy 1-bedroom house on 17 acres in Elizabethtown, IL near the Ohio River.

Cozy 1-bedroom house on 17 acres in Elizabethtown, IL near the Ohio River.
Elizabethtown
10.0 out of 10, Exceptional, (3 reviews)
"Just a wonderful little cabin and extremely helpful host. Loved it"
United States
Jeremiah 33:3 m.
The price is NZ$291
includes taxes & fees
7 Oct - 8 Oct
Cozy 1-bedroom house on 17 acres in Elizabethtown, IL near the Ohio River.
A living room with a stone fireplace, a ceiling fan, a wooden cabinet, and a dining area in the background.

10. Cozy home with the right amenities for your visit to our sweet town.

Cozy home with the right amenities for your visit to our sweet town.
Nashville
10.0 out of 10, Exceptional, (33 reviews)
"Great place to stay!"
United States
Theresa H.
The price is NZ$356
includes taxes & fees
4 Oct - 5 Oct
Cozy home with the right amenities for your visit to our sweet town.
Interior

11. The Vault / Historical 1800s Bank 7min Off I-64. Downtown Main street

The Vault / Historical 1800s Bank 7min Off I-64. Downtown Main street
Fairfield
10.0 out of 10, Exceptional, (19 reviews)
"Just in town for a celebration. Very comfortable, clean and fun place to stay. "
United States
John D.
The price is NZ$207
includes taxes & fees
7 Oct - 8 Oct
The Vault / Historical 1800s Bank 7min Off I-64. Downtown Main street
A dining area with a glass table, four chairs, a vase with flowers, a patterned rug, and two framed pictures on the walls.

12. Comfy Clean & Cute

Comfy Clean & Cute
Marion
9.0 out of 10, Wonderful, (36 reviews)
"House was very clean, really close to everything in town. Host was very easy to communicate with. Will definitely book again when I’m in the area for work related things."
United States
Chris G.
The price is NZ$412
includes taxes & fees
20 Oct - 21 Oct
Comfy Clean & Cute
A corner of a room with a wooden beam, a black hanger, and a folded ironing board against the wall.

13. The Lux Collective- Private Hot Tub, Dry Bar, 1-Acre Yard & Fire Pit

The Lux Collective- Private Hot Tub, Dry Bar, 1-Acre Yard & Fire Pit
Murphysboro
The price is NZ$417
includes taxes & fees
14 Oct - 15 Oct
The Lux Collective- Private Hot Tub, Dry Bar, 1-Acre Yard & Fire Pit
A large white paddle steamer with multiple decks and a prominent red paddle wheel, floating on a calm river.

14. Deluxe Suite - Bungalow overlooking on the Bluff!

Deluxe Suite - Bungalow overlooking on the Bluff!
Stone Church Precinct
9.2 out of 10, Wonderful, (46 reviews)
"Great peaceful location, loved sitting on the porch and watching the barges on the river.9"
United States
michele h.
The price is NZ$295
includes taxes & fees
5 Oct - 6 Oct
Deluxe Suite - Bungalow overlooking on the Bluff!
A room with a brick wall, a coffee machine, and a wooden cart.

15. Explore the Shawnee National Forest-reserve the SHAWNEE HIDEAWAY

Explore the Shawnee National Forest-reserve the SHAWNEE HIDEAWAY
Equality
9.6 out of 10, Exceptional, (25 reviews)
"Great place to stay!"
United States
Alicia J.
The price is NZ$391
includes taxes & fees
4 Oct - 5 Oct
Explore the Shawnee National Forest-reserve the SHAWNEE HIDEAWAY
A wooden cabin entrance with a welcome sign, a small table with a lamp and flowers, and a woven mat on the floor.

16. Vintage Charmer on Main Street

Vintage Charmer on Main Street
Greenup
10.0 out of 10, Exceptional, (77 reviews)
"Great stay !"
United States
chris H.
The price is NZ$251
includes taxes & fees
2 Oct - 3 Oct
Vintage Charmer on Main Street
A cabin with a wooden deck and a 'WELCOME' sign, surrounded by trees.

17. Secluded treehouse with indoor fireplace

Secluded treehouse with indoor fireplace
Makanda
10.0 out of 10, Exceptional, (30 reviews)
"Lovely and peaceful property. Enjoyed our time there will definitely stay again."
United States
James P.
The price is NZ$376
includes taxes & fees
18 Oct - 19 Oct
Secluded treehouse with indoor fireplace
A living room with a brown leather sofa, a wooden coffee table, and a door with a decorative glass panel.

18. Lake of Egypt 4 bedroom home sleeps 8 with dock and flat yard and lakefront!

Lake of Egypt 4 bedroom home sleeps 8 with dock and flat yard and lakefront!
Marion
8.8 out of 10, Excellent, (111 reviews)
"The lake view in the morning"
United States
Dawayne L.
The price is NZ$445
includes taxes & fees
4 Oct - 5 Oct
Lake of Egypt 4 bedroom home sleeps 8 with dock and flat yard and lakefront!
A cozy living room with a wooden ceiling, a dark wood accent wall, a grey sofa with cushions, a white coffee table, and a small side table with a lamp.

19. Charming 1-bedroom house in terrific Harrisburg with AC, WiFi

Charming 1-bedroom house in terrific Harrisburg with AC, WiFi
Harrisburg
9.8 out of 10, Exceptional, (20 reviews)
"We stay here often perfect size and location. "
United States
Cher C.
The price is NZ$305
includes taxes & fees
6 Oct - 7 Oct
Charming 1-bedroom house in terrific Harrisburg with AC, WiFi
A living room with a beige sofa, a fireplace, a television, and a small table with a lamp.

20. Cozy 1-Bedroom Duplex in Belleville

Cozy 1-Bedroom Duplex in Belleville
Belleville
8.8 out of 10, Excellent, (10 reviews)
"You cannot get a better location in Belleville, and far less expensive than renting a hotel room. Would absolutely stay here again. "
United States
Kristen W.
The price is NZ$314
includes taxes & fees
5 Oct - 6 Oct
Cozy 1-Bedroom Duplex in Belleville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Southern Illinois Hotel Reviews

Drury Inn & Suites St. Louis O'Fallon, IL

Drury Inn & Suites St. Louis O'Fallon, IL

10/10 Excellent
"Excellent service"
Robert 2-night trip
Posted 12 hours ago
Drury Inn & Suites St. Louis O'Fallon, IL

Find out more about Southern Illinois

Southern Illinois Holiday Homes information

Number of reviews
506
Accommodation
430 Holiday Homes
Lowest Price
NZ$207
Highest Price
NZ$637

Explore a world of travel with Expedia