Santa Cruz Island Holiday Rentals

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Our top choices for Santa Cruz Island holiday rentals

Aparthotel in Puerto Ayora

Torre Mar Galapagos Boutique Suites
3.0 star property
9.0 out of 10, Wonderful, (16)
"Great room and a very walkable location. John was a fantastic host, has given me his whatsapp on day one and stayed in communication the whole time."
United States
Samuel
Torre Mar Galapagos Boutique Suites

Apartment in Puerto Ayora

Galapagos Coliving Ecuador Casa Tuna
3.0 star property
Galapagos Coliving Ecuador Casa Tuna
The price is NZ$175
24 Jan - 25 Jan 2026
¡Bienvenido a tu hogar isleño en Galápagos!

Apartment in Puerto Ayora, Santa Cruz Island

This two-bedroom is a perfect island getaway.
8.8 out of 10, Excellent, (5)
"Donna communicated with us before our trip to provide information about arrival and to offer transportation assistance from the airport. Once we were there she offered to arrange tours, suggest dining places and made reservations for us. She did everything she could to make our stay easy and enjoyable. On one of the tours she was our guide. That was so helpful."
United States
Cynthia H.
The price is NZ$347
9 Jan - 10 Jan 2026
This two-bedroom is a perfect island getaway.

Holiday Home in Galápagos Islands

Jardin de Galápagos.
The price is NZ$206
5 Jan - 6 Jan 2026
Jardin de Galápagos.

Apartment in Puerto Ayora, Santa Cruz Island

The Oceanview two-bedroom with balcony
10.0 out of 10, Exceptional, (24)
"Excellent place to stay. Walking distance to everything. A small panderia (bakery) a block away has the best croissants for breakfast. Donna and team are phenomenal."
United States
Richard L.
The price is NZ$424
10 Jan - 11 Jan 2026
The Oceanview two-bedroom with balcony
The price is NZ$146
5 Jan - 6 Jan 2026
Charming studio in Puerto Ayora with all the services for a comfortable stay
10.0 out of 10, Exceptional, (1)
"Nice and beautiful house to stay very impressed "
United States
John
The price is NZ$188
4 Jan - 5 Jan 2026
Casa Vacacional en Puerto Ayora, Santa Cruz, Galápagos

Apartment in PUERTO AYORA SANTA CRUZ GALAPAGOS

Apartment near the Sea
8.8 out of 10, Excellent, (5)
"Really nice place!"
United States
Sefora
The price is NZ$291
6 Jan - 7 Jan 2026
Apartment near the Sea

Apartment in Puerto Ayora, Santa Cruz Island

One Bedroom with private balcony
2.0 star property
The price is NZ$283
9 Jan - 10 Jan 2026
One Bedroom with private balcony
The price is NZ$280
5 Jan - 6 Jan 2026
Courtyard Studio perfect for an active Galapagos adventure
The price is NZ$349
8 Jan - 9 Jan 2026
Beautiful rooms with ocean view in Galàpagos VerdeAzul

Apartment in Puerto Ayora, Santa Cruz Island

Ocean view Penthouse
2.0 star property
10.0 out of 10, Exceptional, (1)
"We enjoyed our stay. The air conditioning was a welcome retreat after a day spent exploring. The views are amazing. "
United States
Greta S.
The price is NZ$349
24 Jan - 25 Jan 2026
Ocean view Penthouse
The price is NZ$152
9 Jan - 10 Jan 2026
2-bedroom apartment with AC, WiFi in fabulous Puerto Ayora
The price is NZ$321
25 Dec - 26 Dec
2 Suites Equipadas Para que tu Estancia sea Confortable,ven Galápagos Up Suites

Apartment in Puerto Ayora

GALAPAGOS DIVER ESTUDIO.
10.0 out of 10, Exceptional, (1)
"Perfect start to finish. Very clean! Drinking water provided. The host helped us with a small hiccup regarding our transfer so we were able to catch the ferry to San Cristóbal with no problem. Highly recommend!"
United States
Shannyn Z.
The price is NZ$154
5 Jan - 6 Jan 2026
GALAPAGOS DIVER ESTUDIO.
The price is NZ$205
6 Jan - 7 Jan 2026
Galarous serve you with quality and warmth in your home
The price is NZ$145
6 Jan - 7 Jan 2026
Endemic Suite - Apartamento con Azotea Vista 360

Aparthotel in Puerto Ayora

Galarous island apartments
The price is NZ$222
6 Jan - 7 Jan 2026
Galarous island apartments
The price is NZ$97
11 Jan - 12 Jan 2026
Galarous Island Suite comfortable and cozy
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top Santa Cruz Island Hotel Reviews

Find out more about Santa Cruz Island

Everything you need to know about Santa Cruz Island holiday rentals

Whether you’re excited for the perfect family holiday, a romantic getaway for two, or the ultimate city break, we’ve got the Santa Cruz Island holiday rental for you. At Expedia, you can take your pick from private holiday homes, apartments, cottages, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Santa Cruz Island holiday rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search. 

Santa Cruz Island holiday rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Santa Cruz Island. If you’re looking for a little peace, consider booking during the quieter months, such as  . For more hustle and bustle, you may prefer to visit in . 

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Santa Cruz Island holiday rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a holiday rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Santa Cruz Island holiday rentals we have selected for you start as low as NZ$154 per night. Entering your travel dates in the search wizard you might find even better deals!

How to find incredible deals on Santa Cruz Island rentals

At Expedia, we put the best Santa Cruz Island holiday rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. 

To find some top Santa Cruz Island rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Santa Cruz Island holiday.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Santa Cruz Island. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.