Photo by Skyy

Cape Girardeau County Holiday Rentals

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    bed illustration

    Be picky

    Search almost a million properties worldwide

Top Holiday Rentals Destinations in Cape Girardeau County

Serenity South -- Gardens, River-Views, and Refreshing Space

10.0 out of 10, Exceptional, (134)
"The property was exactly as listed with so many little touches that made it special. Communication was great and we were close to downtown shops and the casino. We will definitely stay again when we are in the area."
The price is NZ$408
includes taxes & fees
14 July - 15 July
Serenity South -- Gardens, River-Views, and Refreshing Space

Downtown 4BR with 2 King Beds! Walking distance to SEMO and the River Front.

8.6 out of 10, Excellent, (15)
"Very clean and spacious. Great location with River Walk and several good restaurants within walking distance. Check in was smooth and host was very responsive. "
Downtown 4BR with 2 King Beds! Walking distance to SEMO and the River Front.

Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO

9.8 out of 10, Exceptional, (35)
"Nice place to stay! Clean, able to walk to everything!"
The price is NZ$230
includes taxes & fees
20 July - 21 July
Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO

"Brickyard" Remodeled 1920's Dutch Colonial Revival in Downtown Cape Girardeau

10.0 out of 10, Exceptional, (19)
"Chip was an excellent host, always available to provide tips about restaurants and answer any questions about the property. Property was in great condition and would not hesitate to recommend."
"Brickyard" Remodeled 1920's Dutch Colonial Revival in Downtown Cape Girardeau

The Twisted Sassafras Treehouse

10.0 out of 10, Exceptional, (15)
"My wife and I thoroughly enjoyed our stay here! A beautiful place built on a beautiful property; we enjoyed the hot tub under the stars and the morning coffee on the porch (and another hot tub ). Great place for some R&R, and excellent communication with the owner in advance. Wouldn’t hesitate to book again."
The price is NZ$505
includes taxes & fees
22 July - 23 July
The Twisted Sassafras Treehouse

Little Blue Cottage on Spanish

8.6 out of 10, Excellent, (41)
"Has everything you need. Comfy and in a great location. "
The price is NZ$168
includes taxes & fees
16 July - 17 July
Little Blue Cottage on Spanish

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

8.8 out of 10, Excellent, (31)
"all was so nice and we enjoyed our stay. grandkids and us loved having pool table and card games and all the peace and quiet there. thank u again for contacting me and giving us address. we appreciated that very much. "
The price is NZ$453
includes taxes & fees
16 July - 17 July
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

Charming Secluded Getaway Cabin within minutes of amenities

10.0 out of 10, Exceptional, (14)
"Nice little Cabin in a beautiful area. Blair and her family were wonderful!"
Charming Secluded Getaway Cabin within minutes of amenities

Beautiful location in the secluded woods

10.0 out of 10, Exceptional, (36)
"If you're looking to visit Holy Boulders, this spot gets you within 5-10 minutes of either trailhead. It was clean, roomy, and has everything you need when you're not at the crag."
The price is NZ$283
includes taxes & fees
15 July - 16 July
Beautiful location in the secluded woods

Brand new cabin in the woods with hot tub 1/2 mile from Starview Winery

10.0 out of 10, Exceptional, (133)
"This cabin was so nice and clean. The beds were very comfortable and this was the perfect location!"
Brand new cabin in the woods with hot tub 1/2 mile from Starview Winery

Stones Throw from Giant City Park, Wineries, Hiking, Biking, Hunting and more.

9.8 out of 10, Exceptional, (55)
"It was a good place for our hiking adventures. Would stay again if we come back "
Stones Throw from Giant City Park, Wineries, Hiking, Biking, Hunting and more.

New cabin in the woods with private hot tub

10.0 out of 10, Exceptional, (117)
"We absolutely love coming here. This was our 2nd stay and getting ready to book it for the fall again. "
New cabin in the woods with private hot tub

Rest, Relax and Renew. Our log cabin experience awaits your arrival.

10.0 out of 10, Exceptional, (389)
"Gorgeous and comfortable property with front porch and back deck. "
The price is NZ$342
includes taxes & fees
20 July - 21 July
Rest, Relax and Renew. Our log cabin experience awaits your arrival.

* Best Location on the Wine Trail! * Hiking Trail 1 min away * Wi-Fi *

10.0 out of 10, Exceptional, (96)
"The place was clean and the host was super nice! We were in town for a wedding at Havisham and this location was perfect! We were able to walk there in just a few minutes!"
* Best Location on the Wine Trail! * Hiking Trail 1 min away * Wi-Fi *

Hot Tub - Minutes from Winetrail, SIU, Giant City, Cedar Lake, Shawnee Forest!

10.0 out of 10, Exceptional, (43)
"Wonderful place to stay while visiting Carbondale."
Hot Tub - Minutes from Winetrail, SIU, Giant City, Cedar Lake, Shawnee Forest!

Feels like your in a Tree House! On the Wine 🍷Trail! Private Location

9.6 out of 10, Exceptional, (216)
"Nice property and Cabin.Property is amazing and very nice Weather had flash flooding when we stayed, but was still nice see creek running like a small river very nice. Would definitely recommend for couples or even with kids."
Feels like your in a Tree House! On the Wine 🍷Trail! Private Location

3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!

9.8 out of 10, Exceptional, (46)
"Owner was so helpful and the cabin was just right for our weekend. "
3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!

Wine Trail, Cozy Cabin plus hot tub

9.8 out of 10, Exceptional, (99)
"Nice property that was conveniently located to the restaurants and wineries we visited during our trip. We hope to return in the future.."
Wine Trail, Cozy Cabin plus hot tub

* On the Wine Trail * Hot Tub * Wi-Fi *

9.8 out of 10, Exceptional, (231)
"Property was just as described! Very centrally located on the wine trail and had everything we needed! "
* On the Wine Trail * Hot Tub * Wi-Fi *

Water to Wine -Private Hot Tub & Winery Across the Lake!

Water to Wine -Private Hot Tub & Winery Across the Lake!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in