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Cape Girardeau Holiday Rentals

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Our top choices for Cape Girardeau holiday rentals

Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO

Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO
Cape Girardeau
9.4 out of 10, Exceptional, (45)
"This place is AWESOME! It's clean, artsy, fun, and if we ever have a chance, we will certainly return!"
United States
Jordan S.
The price is NZ$238
includes taxes & fees
14 Dec - 15 Dec
Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO

Little Blue Cottage on Spanish

Little Blue Cottage on Spanish
Cape Girardeau
8.6 out of 10, Excellent, (48)
"I would definitely stay here again!"
United States
Bonita
The price is NZ$174
includes taxes & fees
15 Dec - 16 Dec
Little Blue Cottage on Spanish

The Cottage, Rusted Route Farms

The Cottage, Rusted Route Farms
Jackson
10.0 out of 10, Exceptional, (2)
"This Cottage was very nice and clean and well maintained. The meat tray that we ordered and the breakfast tray was beyond Fabulous!!! My husband is still talking about it. . .Rick & Renee Christman"
United States
Renee C.
The price is NZ$336
includes taxes & fees
13 Jan - 14 Jan 2026
The Cottage, Rusted Route Farms

Serenity South -- Gardens, River-Views, and Refreshing Space

Serenity South -- Gardens, River-Views, and Refreshing Space
Cape Girardeau
10.0 out of 10, Exceptional, (148)
"Such a great place and location"
United States
Tracy H.
The price is NZ$422
includes taxes & fees
4 Jan - 5 Jan 2026
Serenity South -- Gardens, River-Views, and Refreshing Space

The Twisted Sassafras Treehouse

The Twisted Sassafras Treehouse
Cape Girardeau
10.0 out of 10, Exceptional, (27)
"The place was awesome very clean the host was very accommodating. Nice a quiet for a relaxing stay highly recommend "
United States
Gary C.
The price is NZ$586
includes taxes & fees
12 Jan - 13 Jan 2026
The Twisted Sassafras Treehouse

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Cape Girardeau
8.6 out of 10, Excellent, (36)
"Very nice house. The pool and hot tub were perfect for a short getaway. Tons of activities and games to keep the fanily entertained. Will definitely come back! "
United States
Emily D.
The price is NZ$401
includes taxes & fees
11 Jan - 12 Jan 2026
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

Gorgeous 1856 Log Cabin, Completely Renovated

Gorgeous 1856 Log Cabin, Completely Renovated
Jackson
10.0 out of 10, Exceptional, (3)
"incredible place. I was there for work, but it was a really nice relaxing area to retreat too, and also get some work done in a serene environment. It would be an incredible place for an entire family. And, a good place for friends to get together."
United States
Chandler G.
The price is NZ$534
includes taxes & fees
15 Dec - 16 Dec
Gorgeous 1856 Log Cabin, Completely Renovated

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Cape Girardeau
9.6 out of 10, Exceptional, (7)
"Nice place, great times"
United States
Jace W.
The price is NZ$754
includes taxes & fees
15 Dec - 16 Dec
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

Cozy and Updated Farmhouse with King Suite

Cozy and Updated Farmhouse with King Suite
2.0 star property
Anna
The price is NZ$254
includes taxes & fees
14 Dec - 15 Dec
Cozy and Updated Farmhouse with King Suite

Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!

Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!
Makanda
9.6 out of 10, Exceptional, (39)
"The cabin was perfect for our 5 nights in the area. There was plenty of room and everything we needed. The pictures online were nice but in real life, it was a real gem. Can't wait to visit again."
United States
Victoria H.
The price is NZ$367
includes taxes & fees
22 Dec - 23 Dec
Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!

Beautiful location in the secluded woods

Beautiful location in the secluded woods
Pomona
10.0 out of 10, Exceptional, (60)
"It was very nice and clean. We really enjoyed staying there. We would love to rent this place again. "
United States
susan B.
The price is NZ$281
includes taxes & fees
14 Dec - 15 Dec
Beautiful location in the secluded woods

3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!

3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!
Makanda
9.8 out of 10, Exceptional, (60)
"The property was extremely clean and well cared for.would definitely stay again. "
United States
Dan H.
The price is NZ$312
includes taxes & fees
13 Jan - 14 Jan 2026
3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!

Charming cottage overlooking Lake Acre

Charming cottage overlooking Lake Acre
Dongola
10.0 out of 10, Exceptional, (101)
"Location was great, everything was great for what we were there for. Already booked again for November. "
United States
carlton h.
The price is NZ$484
includes taxes & fees
21 Dec - 22 Dec
Charming cottage overlooking Lake Acre

Rest, Relax and Renew. Our log cabin experience awaits your arrival.

Rest, Relax and Renew. Our log cabin experience awaits your arrival.
Anna
10.0 out of 10, Exceptional, (403)
"Very clean, courteus staff. Beautiful area and quiet. Very relaxing."
United States
Tommy
The price is NZ$349
includes taxes & fees
14 Dec - 15 Dec
Rest, Relax and Renew. Our log cabin experience awaits your arrival.

Cozy cabins on beautiful Horseshoe Lake

Cozy cabins on beautiful Horseshoe Lake
Olive Branch
9.8 out of 10, Exceptional, (35)
"Beautiful place, host was kind and and quick to respond to messages "
United States
Melissa W.
The price is NZ$242
includes taxes & fees
22 Dec - 23 Dec
Cozy cabins on beautiful Horseshoe Lake

Contemporary Glamping with Native American Appeal

Contemporary Glamping with Native American Appeal
Anna
9.8 out of 10, Exceptional, (155)
"Our 2nd time staying here and it was perfect"
United States
machelle p.
The price is NZ$489
includes taxes & fees
17 Dec - 18 Dec
Contemporary Glamping with Native American Appeal

Charming 2-bedroom with AC, WiFi in lovely Jonesboro

Charming 2-bedroom with AC, WiFi in lovely Jonesboro
Jonesboro
10.0 out of 10, Exceptional, (3)
"great place. wonderful host."
United States
Carla m.
The price is NZ$433
includes taxes & fees
14 Dec - 15 Dec
Charming 2-bedroom with AC, WiFi in lovely Jonesboro

Charming 2-bedroom apartment in fabulous Marble Hill with AC

Charming 2-bedroom apartment in fabulous Marble Hill with AC
Marble Hill
7.0 out of 10, Good, (4)
"Host was not properly notified of the booking, but made the accommodations made several trips to make sure we were checked in and comfortable. Also gave very good advice for local points of interest."
United States
Chrystine H.
The price is NZ$230
includes taxes & fees
14 Dec - 15 Dec
Charming 2-bedroom apartment in fabulous Marble Hill with AC

The Rested Duck Mallard Room

The Rested Duck Mallard Room
Olive Branch
9.2 out of 10, Wonderful, (25)
"This is an excellent place to stay. With a nice lake right across the street. If i. In the are i will stay again for sure"
United States
mike b.
The price is NZ$242
includes taxes & fees
21 Dec - 22 Dec
The Rested Duck Mallard Room

Villa B offers peace and quiet with beautiful views of the countryside.

Villa B offers peace and quiet with beautiful views of the countryside.
Jackson
10.0 out of 10, Exceptional, (11)
"Our stay was amazing. Everything was so clean organized, and anything you would possibly need was in the room. We will definitely be staying there again when in the area!!"
United States
Karen P.
The price is NZ$318
includes taxes & fees
2 Jan - 3 Jan 2026
Villa B offers peace and quiet with beautiful views of the countryside.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Cape Girardeau Hotel Reviews

Find out more about Cape Girardeau

Everything you need to know about Cape Girardeau holiday rentals

Whether you’re excited for the perfect family holiday, a romantic getaway for two, or the ultimate city break, we’ve got the Cape Girardeau holiday rental for you. At Expedia, you can take your pick from private holiday homes, apartments, cottages, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Cape Girardeau holiday rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search. 

Cape Girardeau holiday rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Cape Girardeau. If you’re looking for a little peace, consider booking during the quieter months, such as  . For more hustle and bustle, you may prefer to visit in . 

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Cape Girardeau holiday rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a holiday rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Cape Girardeau holiday rentals we have selected for you start as low as NZ$174 per night. Entering your travel dates in the search wizard you might find even better deals!

How to find incredible deals on Cape Girardeau rentals

At Expedia, we put the best Cape Girardeau holiday rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. 

To find some top Cape Girardeau rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Cape Girardeau holiday.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Cape Girardeau. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence. 

Frequently asked questions

Can I find holiday rentals in Cape Girardeau?

Yes, there are holiday rentals in Cape Girardeau close to Cape Splash Family Aquatic Center, or you can select a more secluded option if you're looking for a relaxing stay. Visitors like the top-notch restaurants and shops in Cape Girardeau. Make sure you allow time to enjoy the riverfront during your holiday.

What are some of the best holiday rentals that Cape Girardeau has to offer?

“Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau: This highly rated holiday home rental in Cape Girardeau is located on a river, and has a patio, a garden and a BBQ to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. You and your friends and family can relax into your holiday with amenities such as a selection of games. Some other homes for rent in Cape Girardeau include Little Blue Cottage on Spanish and 3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau.

How many holiday rentals will I find in Cape Girardeau?

Choose from 22 Expedia holiday rentals in Cape Girardeau for a memorable holiday.

What can I see and do in Cape Girardeau?

Family-friendly attractions include Cape Splash Family Aquatic Center and Cape Girardeau Conservation Nature Center, whereas Shawnee National Forest and Mississippi River are a couple of great spots to enjoy the outdoors. While here, Isle Casino Cape Girardeau and Show Me Center are other places worth a visit.

What are holiday rentals like in Cape Girardeau?

Holiday rentals are privately owned properties you can book for a few days, or a quick weekend, in Cape Girardeau. Holiday rentals offer amenities such as laundry facilities and kitchens so you'll feel just like you're staying in your own home. If you're concerned about cleanliness, a holiday rental can provide a sense of security away from public hotel lifts and busy front desks while still allowing you the experience of travel. You'll also find more space in a holiday rental than in a hotel, which is another reason why a holiday rental is an attractive choice for a small group gathering.