
Cape Girardeau Holiday Rentals
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Our top choices for Cape Girardeau holiday rentals

1. Little Blue Cottage on Spanish
Little Blue Cottage on Spanish
2. Cozy 2-bedroom house in tranquil Cape Girardeau, close to Semo & Hospitals
Cozy 2-bedroom house in tranquil Cape Girardeau, close to Semo & Hospitals
3. Purple Tiny House with Fire pit & Nature
Purple Tiny House with Fire pit & Nature
4. Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly
Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly
5. Enchanted Mermaid A-Frame | Creek + Fire pit | Pet Friendly
Enchanted Mermaid A-Frame | Creek + Fire pit | Pet Friendly
6. The Little Château | Woodland Escape
The Little Château | Woodland Escape
7. The Cottage, Rusted Route Farms
The Cottage, Rusted Route Farms
8. The Little Cape Lofted Cottage | Creek & Nature
The Little Cape Lofted Cottage | Creek & Nature
9. 3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
10. The Twisted Sassafras Treehouse
The Twisted Sassafras Treehouse
11. Gorgeous 1856 Log Cabin, Completely Renovated
Gorgeous 1856 Log Cabin, Completely Renovated
12. Beautifully Renovated Farmhouse in Jackson, MO
Beautifully Renovated Farmhouse in Jackson, MO
13. 4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
14. Cozy cabins on beautiful Horseshoe Lake
Cozy cabins on beautiful Horseshoe Lake
15. The Rested Duck Mallard Room
The Rested Duck Mallard Room
16. 3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!
3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!
17. Relax in the country at Countryside Villas! - Villa A
Relax in the country at Countryside Villas! - Villa A
18. Villa B offers peace and quiet with beautiful views of the countryside.
Villa B offers peace and quiet with beautiful views of the countryside.
19. Peaceful secluded cabin located near Horseshoe Lake
Peaceful secluded cabin located near Horseshoe LakeFind holiday rentals that suit your style
Top Cape Girardeau Hotel Reviews

Drury Inn & Suites Cape Girardeau
Find out more about Cape Girardeau
You always said you would go on a dream holiday someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannonball into the deep end. Go ahead, unplug and unwind in style. When you book one of our Cape Girardeau holiday rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your holiday just got upgraded.
As much as you love your vacation rental, it’s always good to get out and explore to soak up Cape Girardeau. Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in Cape Girardeau. Seeing all the best attractions is bound to make you fall in love with Cape Girardeau. Who knows, you may even be tempted to extend your stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.
It’s your escape so why share it? You deserve your own slice of paradise. Booking your holiday rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in Cape Girardeau short-term rentals, that won’t be hard to do.

































































