Book Audrain County Hotels

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
6 Dec - 7 Dec
Tomorrow
7 Dec - 8 Dec
Next weekend
12 Dec - 14 Dec
In two weeks
19 Dec - 21 Dec

Filter by

Guest rating
Guest rating
Star rating

Top Hotels in Audrain County

Exterior
Best Western Teal Lake Inn

Best Western Teal Lake Inn

2.5 star property
Mexico
8.4 out of 10, Very good, (482)
"It was a great stay and very quiet. The restful sleep was enjoyable."
United States
Eric
The price is NZ$160
includes taxes & fees
4 Jan - 5 Jan 2026
Best Western Teal Lake Inn
Indoor pool
Capital O Amerihost Inn and Suites Mexico Hwy 54 MO

Capital O Amerihost Inn and Suites Mexico Hwy 54 MO

2.5 star property
Mexico
5.6 out of 10, (383)
"Staff were very friendly and accommodating. Room was very clean and comfortable!"
United States
Rusty
Capital O Amerihost Inn and Suites Mexico Hwy 54 MO
Exterior
Days Inn by Wyndham Mexico

Days Inn by Wyndham Mexico

2.0 star property
Mexico
7.0 out of 10, Good, (296)
"Comfortable bed... Didn't like stool loose on base."
United States
Marvin
The price is NZ$148
includes taxes & fees
21 Dec - 22 Dec
Days Inn by Wyndham Mexico
Reception
Budget Inn Mexico MO on US 54

Budget Inn Mexico MO on US 54

2.0 star property
Mexico
7.0 out of 10, Good, (110)
"Great "
United States
Jedrzej
The price is NZ$165
includes taxes & fees
15 Dec - 16 Dec
Budget Inn Mexico MO on US 54
Fridge, microwave, oven, stovetop
Rustic 2-bedroom cabin next to 1000+ acre Conservation area near Mark Twain Lake

Rustic 2-bedroom cabin next to 1000+ acre Conservation area near Mark Twain Lake

2.0 star property
Paris
8.8 out of 10, Excellent, (5)
"The cabin was very clean and the Host was very nice and helpful."
United States
TREY
The price is NZ$436
includes taxes & fees
2 Jan - 3 Jan 2026
Rustic 2-bedroom cabin next to 1000+ acre Conservation area near Mark Twain Lake
House (1 Bedroom) | Interior
'grace Place' Clark House on Farm: Shared Hot Tub!

'grace Place' Clark House on Farm: Shared Hot Tub!

3.0 star property
Clark
10.0 out of 10, Exceptional, (2)
"Very clean with a wonderful country atmosphere. Perfect size for 1-2 people to share. The farm animals won my heart over!!!!!!!"
United States
Becky
'grace Place' Clark House on Farm: Shared Hot Tub!
Apartment (2 Bedrooms) | Front of property
'kimberly's Hope' Clark Apt on Farm w/ Pool Access

'kimberly's Hope' Clark Apt on Farm w/ Pool Access

3.0 star property
Clark
'kimberly's Hope' Clark Apt on Farm w/ Pool Access
Interior
Sisters Four Bed and Bath - Luxury living in a small town atmosphere!

Sisters Four Bed and Bath - Luxury living in a small town atmosphere!

Centralia
10.0 out of 10, Exceptional, (33)
"Clean, beautiful property for family to stay in."
United States
Janine V.
Sisters Four Bed and Bath - Luxury living in a small town atmosphere!
House (2 Bedrooms) | Interior
Historic Clark Cabin w/ Deck & Fishing Pond Access

Historic Clark Cabin w/ Deck & Fishing Pond Access

3.0 star property
Clark
Historic Clark Cabin w/ Deck & Fishing Pond Access
Interior
Rut & Strut Ranch - 35 minutes from Mark Twain Lake! Quiet Cabin in the woods

Rut & Strut Ranch - 35 minutes from Mark Twain Lake! Quiet Cabin in the woods

Thompson
10.0 out of 10, Exceptional, (15)
"Nice cabin in quiet woods with a pond."
United States
Mary
Rut & Strut Ranch - 35 minutes from Mark Twain Lake! Quiet Cabin in the woods
Outdoor dining
Tastefully restored historic home in quaint town, 20 minute drive to Columbia MO

Tastefully restored historic home in quaint town, 20 minute drive to Columbia MO

Centralia
10.0 out of 10, Exceptional, (154)
"Always wonderful staying at the Rollins House Inn! "
United States
Syndy D.
Tastefully restored historic home in quaint town, 20 minute drive to Columbia MO
Non-Smoking
America's Value Inn Mexico

America's Value Inn Mexico

1.5 star property
Mexico
5.4 out of 10, (19)
"who ever owns this property I met him ,seems to be very humble. He needs to update this property . i dont mind paying more if everything is well maintained and welcoming. "
United States
Sopan
America's Value Inn Mexico
Pool
Relax fish/play: Pvt 25-acre clear Blue Lake w/ home that sleeps 10 comfortably.

Relax fish/play: Pvt 25-acre clear Blue Lake w/ home that sleeps 10 comfortably.

2.0 star property
Mexico
10.0 out of 10, Exceptional, (12)
"This was our 3rd stay, and it was amazing again! "
United States
Bert and Naomi W.
Relax fish/play: Pvt 25-acre clear Blue Lake w/ home that sleeps 10 comfortably.
Dining
Beautiful historic home in downtown Centralia, just 20 minutes from Columbia, MO

Beautiful historic home in downtown Centralia, just 20 minutes from Columbia, MO

Centralia
10.0 out of 10, Exceptional, (45)
"I loved the process for reserving the room. Also, the property was clean and provided what we needed for the event. This is an excellent home to rent!"
United States
Ieti F.
Beautiful historic home in downtown Centralia, just 20 minutes from Columbia, MO
Exterior
Two-House Private Country Retreat - 4 Bedrooms and 3.5 Baths

Two-House Private Country Retreat - 4 Bedrooms and 3.5 Baths

Auxvasse, MO
10.0 out of 10, Exceptional, (30)
"This is an absolutely beautiful home in a tranquil setting. We have stayed in many rentals and this one outshines them all in every area!!"
United States
Angela B.
Two-House Private Country Retreat - 4 Bedrooms and 3.5 Baths
House (3 Bedrooms) | Interior
Dog-friendly Cabin w/ Yard Near Auxvasse Creek!

Dog-friendly Cabin w/ Yard Near Auxvasse Creek!

3.0 star property
Kingdom City
Dog-friendly Cabin w/ Yard Near Auxvasse Creek!
Dining
Retreat on the Creek: Home overlooking a backyard lake and the Auxvasse Creek

Retreat on the Creek: Home overlooking a backyard lake and the Auxvasse Creek

2.0 star property
Kingdom City
9.6 out of 10, Exceptional, (10)
"Beautiful location "
United States
Scott H.
Retreat on the Creek: Home overlooking a backyard lake and the Auxvasse Creek
Microwave, dishwasher, coffee/tea maker, toaster
Dog-Friendly Cabin w/ Yard Near Auxvasse Creek!

Dog-Friendly Cabin w/ Yard Near Auxvasse Creek!

2.0 star property
Kingdom City
Dog-Friendly Cabin w/ Yard Near Auxvasse Creek!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Audrain County Hotel Reviews

Drury Inn & Suites Columbia Stadium Boulevard

Drury Inn & Suites Columbia Stadium Boulevard

10/10 Excellent
"We had a last-minute change in our plans and picked up this hotel on way. We were not able to make the dinner time snacks or the complementary drinks. The room was comfortable and very clean. The pillows were comfortable. The sound in the room was absolutely fantastic. No outside noise no distracting ice machine couldn’t even hear the highway! The buffet breakfast was fantastic other than the pot machine happen to be broken that morning. Everyone bent over backwards to make sure that our stay was completely comfortable and every way. Will definitely stay here again. "
Nancy 1-night trip
Posted 1 day ago
Drury Inn & Suites Columbia Stadium Boulevard

Explore a world of travel with Expedia