Photo by Southernmost Illinois Tourism Bureau

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Top Pet-friendly Southern Illinois Hotels

La Quinta Inn & Suites by Wyndham Effingham

1103 Avenue Of Mid America, Effingham, IL

4 hours drive from Shawnee National Forest

Stay at this 3-star business-friendly hotel in Effingham. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...

9.2/10 Wonderful! (1,007 reviews)

"Close to shopping and dining. Great location."

Reviewed on 16 Aug. 2025

La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis

136 Regency Park, O'Fallon, IL

4 hours drive from Shawnee National Forest

Stay at this 3-star business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...

6/10 (1,004 reviews)

One Night Stay

"We are traveling across country on a budget so for the price this was an excellent stay. Comfortable bed, real shower. Here are some issues, if mitigated, would have uped my review to 4. Hallway carpet and room carpet need a good cleaning. Overhead light in room was burned out,, refrigerator cabinet ..."

Reviewed on 31 Jul. 2025

Red Roof Inn St Louis - Troy, IL

2030 Formosa Road, Troy, IL

4 hours drive from Shawnee National Forest

Book a stay at this business-friendly hotel in Troy. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...

7.6/10 Good! (1,002 reviews)

"Commode eats was loose."

Reviewed on 7 Aug. 2025

See all 1,055 properties in Southern Illinois

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.