Photo by JG Morris

Plan, book, travel with confidence
Better together
Save up to NZ$616 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Pet-friendly Southeast Missouri Hotels

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

3 hours drive from Mark Twain National Forest

Stay at this motel in Poplar Bluff. Enjoy free Wi-Fi, free parking and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in their ...

7.8/10 Good! (1,009 reviews)

Was on a roadtrip to Texas was a great stay nice hot water nice bed

Reviewed on 28 Nov 2025

Microtel Inn & Suites by Wyndham Sainte Genevieve

21958 Hwy 32 Ste Genevieve MO

4 hours drive from Mark Twain National Forest

Stay at this business-friendly hotel in Ste Genevieve. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean rooms ...

8.6/10 Excellent! (609 reviews)

The staff was amazing and I will definitely be stopping in again

Reviewed on 26 Nov 2025

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

1001 Veterans Blvd Festus MO

3 hours drive from Mark Twain National Forest

Stay at this business-friendly hotel in Festus. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in their ...

7.8/10 Good! (882 reviews)

Everything was

Reviewed on 30 Nov 2025

See all 618 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.