Top Pet-friendly Southeast Missouri Hotels

Motel 6 Poplar Bluff, MO

4101 Highway 67 N, Poplar Bluff, MO

3 hours drive from Mark Twain National Forest

Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...

7.8/10 Good! (1,005 reviews)

"I appreciate the lower prices being avaiable in the area. But it was only a few years ago that a lower price ranged $55 - $70 and when I started using Motel 6 a few years prior to that it was a VERY common to get a "Clean, Comfortable Room" pretty much anywhere in the Midwest for $39 per night. I ..."

Reviewed on 15 Aug. 2025

Microtel Inn & Suites by Wyndham Sainte Genevieve

21958 Hwy 32, Ste Genevieve, MO

4 hours drive from Mark Twain National Forest

Book a stay at this business-friendly hotel in Ste Genevieve. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...

8.6/10 Excellent! (588 reviews)

Trip to Ste Genevieve

"The beds were firm, which I like and very clean. Plenty of towels from day one. Internet was great and tv options were great too. Front desk associates did a great job."

Reviewed on 12 Aug. 2025

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

1001 Veterans Blvd, Festus, MO

3 hours drive from Mark Twain National Forest

Stay at this 3-star business-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...

7.8/10 Good! (831 reviews)

"Clean rooms that smell good. Very nice and welcoming staff. Everything was great."

Reviewed on 18 Aug. 2025

See all 585 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.