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Top Pet-friendly Southeast Missouri Hotels

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

3 hours drive from Mark Twain National Forest

Stay at this motel in Poplar Bluff. Enjoy free Wi-Fi, free parking and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in their ...

7.8/10 Good! (1,006 reviews)

Desk clerk was extra helpful. My TV remote wasn’t working. He found a replacement and came to the room to make sure. He went the extra mile.

Reviewed on 12 Jan 2026

Microtel Inn & Suites by Wyndham Sainte Genevieve

21958 Hwy 32 Ste Genevieve MO

4 hours drive from Mark Twain National Forest

Stay at this business-friendly hotel in Ste Genevieve. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean rooms ...

8.6/10 Excellent! (614 reviews)

The room was very clean and had a comfortable feeling to it. I liked that I could easily control the temperature in the room. The manager was responsive. However, I had to change rooms because the TV set wouldn’t work in the first room.

Reviewed on 30 Dec 2025

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

1001 Veterans Blvd Festus MO

3 hours drive from Mark Twain National Forest

Stay at this business-friendly hotel in Festus. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in their ...

7.8/10 Good! (903 reviews)

Clean room

Reviewed on 29 Dec 2025

See all 621 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.