Lodging Image

Uptown Greenville Hotels, Greenville

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
28 Aug - 30 Aug
Next weekend
4 Sept - 6 Sept

Filter by

Property class

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Uptown Greenville hotels

Exterior

1. Hilton Garden INN Greenville University

Hilton Garden INN Greenville University
3.0 star property
Uptown Greenville
9.4 out of 10, Exceptional, (161 reviews)
"Best hotel in Greenville with a good restaurant in a great bar."
United States
Mark
The price is NZ$231
includes taxes & fees
20 Sept - 21 Sept
Hilton Garden INN Greenville University
Exterior

2. Holiday Inn Express Greenville by IHG

Holiday Inn Express Greenville by IHG
2.5 star property
2.3 km from Uptown Greenville
8.4 out of 10, Very good, (1,005 reviews)
"Breakfast was top class...Probably the best place we ate on the whole vacation. Nice rooms, nice staff...excellent place to stay"
United States
Tim
The price is NZ$208
includes taxes & fees
30 Aug - 31 Aug
Holiday Inn Express Greenville by IHG
Terrace/patio

3. Residence Inn by Marriott Greenville

Residence Inn by Marriott Greenville
3.0 star property
2.4 km from Uptown Greenville
8.8 out of 10, Excellent, (526 reviews)
"The facilities were clean and quiet and the breakfast was good."
United States
Steve
The price is NZ$217
includes taxes & fees
26 Aug - 27 Aug
Residence Inn by Marriott Greenville
Indoor pool

4. Fairfield Inn & Suites by Marriott Greenville

Fairfield Inn & Suites by Marriott Greenville
3.0 star property
2.4 km from Uptown Greenville
8.6 out of 10, Excellent, (504 reviews)
"Clean room and nice breakfast!"
United States
Frank
The price is NZ$247
includes taxes & fees
29 Aug - 30 Aug
Fairfield Inn & Suites by Marriott Greenville
Terrace/patio

5. Homewood Suites By Hilton Greenville, NC

Homewood Suites By Hilton Greenville, NC
3.0 star property
2.4 km from Uptown Greenville
9.2 out of 10, Wonderful, (407 reviews)
"It's the next best thing to your comfy home."
United States
William-Karla
The price is NZ$215
includes taxes & fees
3 Sept - 4 Sept
Homewood Suites By Hilton Greenville, NC
Suite, 2 Queen Beds, Non Smoking, Refrigerator & Microwave (with Sofabed)

6. Best Western Plus Suites-Greenville

Best Western Plus Suites-Greenville
2.5 star property
3.9 km from Uptown Greenville
9.0 out of 10, Wonderful, (1,014 reviews)
"Great stay"
United States
Tommy
The price is NZ$211
includes taxes & fees
30 Aug - 31 Aug
Best Western Plus Suites-Greenville
View from property

7. Courtyard Marriott Greenville

Courtyard Marriott Greenville
3.0 star property
Medical District, 2.8 km from Uptown Greenville
8.8 out of 10, Excellent, (932 reviews)
"Great hospitality"
United States
Quentin
The price is NZ$239
includes taxes & fees
30 Aug - 31 Aug
Courtyard Marriott Greenville
Exterior

8. Staybridge Suites Greenville Medical Center by IHG

Staybridge Suites Greenville Medical Center by IHG
3.0 star property
2.3 km from Uptown Greenville
9.2 out of 10, Wonderful, (356 reviews)
"Awesome Stay !!"
United States
Levi
The price is NZ$216
includes taxes & fees
30 Aug - 31 Aug
Staybridge Suites Greenville Medical Center by IHG
Exterior

9. Microtel Inn & Suites by Wyndham Greenville/University Medic

Microtel Inn & Suites by Wyndham Greenville/University Medic
2.0 star property
2.5 km from Uptown Greenville
7.0 out of 10, Good, (1,018 reviews)
"Wonderful staff"
United States
Hipolito
The price is NZ$129
includes taxes & fees
13 Sept - 14 Sept
Microtel Inn & Suites by Wyndham Greenville/University Medic
Lobby

10. Quality Inn Greenville near University

Quality Inn Greenville near University
2.5 star property
2 km from Uptown Greenville
7.4 out of 10, Good, (1,009 reviews)
"Nice place 👍"
United States
Dereck
The price is NZ$143
includes taxes & fees
14 Sept - 15 Sept
Quality Inn Greenville near University
Exterior

11. Holiday Inn Greenville by IHG

Holiday Inn Greenville by IHG
3.0 star property
Convention District, 4.3 km from Uptown Greenville
8.8 out of 10, Excellent, (1,011 reviews)
"great place to stay"
United States
Bridget
The price is NZ$170
includes taxes & fees
21 Sept - 22 Sept
Holiday Inn Greenville by IHG
Terrace/patio

12. Hampton Inn Greenville

Hampton Inn Greenville
2.5 star property
Convention District, 4.3 km from Uptown Greenville
9.0 out of 10, Wonderful, (659 reviews)
"I had a great stay"
United States
Michael
The price is NZ$233
includes taxes & fees
6 Sept - 7 Sept
Hampton Inn Greenville
Lobby

13. Econo Lodge Greenville near University

Econo Lodge Greenville near University
2.0 star property
2.3 km from Uptown Greenville
7.2 out of 10, Good, (462 reviews)
"Nice place, is great for a whole family, close to beaches."
United States
Gerardo
The price is NZ$137
includes taxes & fees
27 Aug - 28 Aug
Econo Lodge Greenville near University
Lobby

14. Comfort Inn & Suites Greenville Near East Carolina University

Comfort Inn & Suites Greenville Near East Carolina University
2.5 star property
4.9 km from Uptown Greenville
8.8 out of 10, Excellent, (530 reviews)
"Clean property, helpful and friendly staff, and wonderful breakfast."
United States
Kendall
The price is NZ$207
includes taxes & fees
6 Sept - 7 Sept
Comfort Inn & Suites Greenville Near East Carolina University
Lobby

15. Super 8 by Wyndham Greenville

Super 8 by Wyndham Greenville
2.0 star property
2.3 km from Uptown Greenville
6.6 out of 10, (604 reviews)
"Great place to stay"
United States
ShaQuita
The price is NZ$156
includes taxes & fees
13 Sept - 14 Sept
Super 8 by Wyndham Greenville
Terrace/patio

16. Hilton Greenville

Hilton Greenville
4.0 star property
Convention District, 4.5 km from Uptown Greenville
8.8 out of 10, Excellent, (570 reviews)
"Conveniently located and excellent service!"
United States
Monte
The price is NZ$293
includes taxes & fees
30 Aug - 31 Aug
Hilton Greenville
Exterior

17. Candlewood Suites Greenville NC by IHG

Candlewood Suites Greenville NC by IHG
2.5 star property
4.7 km from Uptown Greenville
8.4 out of 10, Very good, (659 reviews)
"Nice accommodations, staff was very friendly, could use a little updating."
United States
Amanda
The price is NZ$185
includes taxes & fees
6 Sept - 7 Sept
Candlewood Suites Greenville NC by IHG
Free WiFi, bed sheets

18. Motel 6 Greenville, NC – ECU-Medical Center

Motel 6 Greenville, NC – ECU-Medical Center
2.0 star property
2.2 km from Uptown Greenville
6.6 out of 10, (130 reviews)
"I like that the bed had good covering. Not just a thin sheet and AC worked wonderfully."
United States
Renee
The price is NZ$138
includes taxes & fees
25 Aug - 26 Aug
Motel 6 Greenville, NC – ECU-Medical Center
Lobby

19. Red Roof Inn Greenville, NC

Red Roof Inn Greenville, NC
2.0 star property
3.4 km from Uptown Greenville
4.8 out of 10, (286 reviews)
"N/A"
United States
Orlando
The price is NZ$120
includes taxes & fees
28 Aug - 29 Aug
Red Roof Inn Greenville, NC
Suite, 1 Bedroom, Non Smoking, Jetted Tub

20. Country Inn & Suites by Radisson, Greenville, NC

Country Inn & Suites by Radisson, Greenville, NC
3.0 star property
6.7 km from Uptown Greenville
7.6 out of 10, Good, (913 reviews)
"Clean and comfortable. I had a nice quiet stay."
United States
Lakeisha
The price is NZ$176
includes taxes & fees
20 Sept - 21 Sept
Country Inn & Suites by Radisson, Greenville, NC
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Our guide on where to stay in Uptown Greenville

Find the best Uptown Greenville areas for the activities you enjoy most.

University District

While University District isn't home to many top sights, Dowdy–Ficklen Stadium and Williams Arena at Minges Coliseum are some notable places to visit nearby.

Convention District

When in Convention District, you can plan a visit to Williams Arena at Minges Coliseum and Dowdy–Ficklen Stadium, some noteworthy sights in the nearby area.

Medical District

If you're looking for some top things to see and do in Medical District and surrounding area, you can visit North Pines and Arlington Crossing.

Westhaven

Westhaven might not have many top sights, but 11 Galleria and Williams Arena at Minges Coliseum are two attractions nearby that you can check out.

A cityscape with a dense forest in the foreground and a clear blue sky.

College View Historic District

If you're looking for some top things to see and do in College View Historic District and surrounding area, you can visit Williams Arena at Minges Coliseum and Dowdy–Ficklen Stadium.

Top Uptown Greenville Hotel Reviews

Recent Reviews in Uptown Greenville

Best Western Plus Suites-Greenville

Best Western Plus Suites-Greenville

10/10 Excellent
"Great stay"
Ezekiel 2-night trip
Posted 2 hours ago
Best Western Plus Suites-Greenville

Frequently asked questions

What are the best family hotels in Uptown Greenville?
For an excellent family stay in Uptown Greenville, consider the Hilton Garden INN Greenville University.

The 3-star Hilton Garden Inn Greenville University, with an outstanding 9.4 rating, is a superb choice for families. This hotel offers complimentary cribs and connecting rooms, which are very convenient for larger families. It is located in a historical and shopping district, making it easy to explore. Guests will appreciate the on-site gift shops or newsstand and a grocery or convenience store for any family needs. The hotel is also very close to Town Common, just 0.5 km away, providing a pleasant area for families to relax.
What are the top pet-friendly hotels in Uptown Greenville?
For a highly-rated pet-friendly hotel in Uptown Greenville, consider the Hilton Garden INN Greenville University.

This 3-star hotel, with an impressive 9.4 rating, warmly welcomes pets, making it an excellent choice for travellers with animal companions. It is conveniently located in a historical district, close to a shopping district, and has a museum nearby. Guests will find a gift shop or newsstand on-site, as well as a grocery and convenience store for any necessities. The hotel is also just 0.5 km from Town Common, offering easy access to a pleasant green space.
What are the best budget hotels in Uptown Greenville?
For a budget-friendly and highly-rated hotel in Uptown Greenville, consider the Hilton Garden INN Greenville University.

The 3-star Hilton Garden Inn Greenville University, with an impressive 9.4 rating, offers a comfortable stay with excellent amenities. It is conveniently located in a historical and shopping district, with a museum nearby. Guests can enjoy complimentary WiFi and the convenience of a gift shop or newsstand, as well as a grocery or convenience store on-site. The hotel is also well-situated for exploring local attractions, being just 0.5 km from Town Common.
When is the best time to go to Uptown Greenville?
The best time to go to Uptown Greenville is during the spring (April to May) and autumn (September to October) months.

During these periods, the weather is pleasantly mild with comfortable temperatures, making it ideal for exploring the city's outdoor attractions and enjoying events. You'll find fewer humid days compared to summer, and the natural beauty of North Carolina is on full display, especially the autumn foliage.

For those interested in university activities, visiting in late spring or early autumn allows you to experience the buzz of East Carolina University without the peak summer heat.
Can I cancel my hotel reservation on Expedia?
Many Expedia hotel reservations are refundable, provided that you cancel before the hotel's cancellation deadline − this is often within 24 to 48 hours of your scheduled arrival. If you have a non-refundable booking, it might still be possible to receive a refund if you cancel it within 24 hours of booking. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use our 'Fully refundable property' filter during your search to find the right Uptown Greenville hotel for you.
How can I save on a hotel booking in Uptown Greenville with Expedia?
One Key™—Expedia's free travel rewards program—gives you instant access to discounts with Member Prices on Uptown Greenville hotels. Plus, you'll earn OneKeyCash™* on eligible bookings to use on future trips. Booking an Expedia hotel and flight package is another great way to save, where bundling can result in significant savings. *Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
How much is the nightly rate for a hotel in Uptown Greenville?
Hotel prices in Uptown Greenville often vary, but you can find a great deal on Expedia. Different factors affect nightly hotel rates, such as the time of year or the days of the week you want to book. To find the best deals for your stay, be flexible with your dates and sort search results by 'Price: low to high' for our cheapest rates.