Uptown Greenville Holidays
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to NZ$616 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Our guide on where to stay in Uptown Greenville
Find the best Uptown Greenville areas and neighborhoods for the activities you enjoy most. Learn more about Uptown Greenville
Medical District
1 out of top 10 points of interest in this area
If you're looking for some top things to see and do in Medical District and surrounding area, you can visit Arlington Crossing and North Pines.
Our pick of the best Uptown Greenville Hotel Deals
Hilton Garden INN Greenville University
423 EVANS ST Greenville NC
Fully refundableReserve now, pay when you stay
The price is NZ$272 per night from 18 Jan to 19 Jan
NZ$272
18 Jan - 19 Jan
includes taxes & fees
9.4/10 Exceptional! (96 reviews)
The best and cleanest hotel I have stayed at in a long while. The staff was friendly from the manager to the housekeepers to the restaurant staff. The breakfast was amazing. They offer contenental breakfast along with made to order eggs and omelets. We will definitely stay again.
Reviewed on 27 Dec 2025
Baymont by Wyndham Greenville
3439 S Memorial Drive Greenville NC
Fully refundableReserve now, pay when you stay
The price is NZ$102 per night from 23 Jan to 24 Jan
NZ$102
23 Jan - 24 Jan
includes taxes & fees
6.4/10 (1,000 reviews)
Manager was very polite. Bedding was nice & clean as requested. Property is getting better with each visit. I love staying here because of smoking accommodations as well
Reviewed on 28 Dec 2025
Staybridge Suites Greenville Medical Center by IHG
930 Crosswind Street Greenville NC
Fully refundable
The price is NZ$196 per night from 11 Jan to 12 Jan
NZ$196
11 Jan - 12 Jan
includes taxes & fees
9.2/10 Wonderful! (256 reviews)
The staff was very friendly and courteous
Reviewed on 1 Jan 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.