Search Defiance hotels

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
8 Apr - 9 Apr
Tomorrow
9 Apr - 10 Apr
This weekend
10 Apr - 12 Apr
Next weekend
17 Apr - 19 Apr

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Defiance hotels

Indoor pool

Baymont by Wyndham Warrenton

Baymont by Wyndham Warrenton
2.5 star property
Warrenton
7.6 out of 10, Good, (1,001 reviews)
"The room was clean. The parking was easy."
United States
Chris
The price is NZ$145
includes taxes & fees
22 Apr - 23 Apr
Baymont by Wyndham Warrenton
Reception

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3.0 star property
Fenton
8.0 out of 10, Very good, (1,190 reviews)
"Everything was great for overnight stay. "
United States
Regina
The price is NZ$177
includes taxes & fees
10 May - 11 May
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Lobby

Quality Inn Foristell

Quality Inn Foristell
2.5 star property
Foristell
8.2 out of 10, Very good, (961 reviews)
"Comfy beds, but the trim, doors, and other finishings look pretty rough and in need of replacement. Simple enough breakfast and was just there for a night to sleep so it did the job."
United States
Laura
The price is NZ$173
includes taxes & fees
6 May - 7 May
Quality Inn Foristell
Reception

Hampton Inn St. Louis Wentzville

Hampton Inn St. Louis Wentzville
2.5 star property
Wentzville
9.0 out of 10, Wonderful, (685 reviews)
"Very pet friendly. "
United States
Sara
The price is NZ$251
includes taxes & fees
15 Apr - 16 Apr
Hampton Inn St. Louis Wentzville
Exterior

Holiday Inn Express & Suites St Peters by IHG

Holiday Inn Express & Suites St Peters by IHG
2.5 star property
St. Peters
9.4 out of 10, Exceptional, (398 reviews)
"Kelly & the other staff were wonderful. You breakfast options are great!"
United States
Cynthia
The price is NZ$245
includes taxes & fees
12 Apr - 13 Apr
Holiday Inn Express & Suites St Peters by IHG
Standard Room, 2 Queen Beds

Super 8 by Wyndham Warrenton

Super 8 by Wyndham Warrenton
2.0 star property
Warrenton
7.4 out of 10, Good, (639 reviews)
"The parking was easy, the room was verry clean."
United States
Gary
The price is NZ$110
includes taxes & fees
23 Apr - 24 Apr
Super 8 by Wyndham Warrenton
Room, 2 Queen Beds, Non Smoking

Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66
3.0 star property
Fenton
7.8 out of 10, Good, (1,190 reviews)
"Excellent staff and stay was pleasant "
United States
Jacob
The price is NZ$169
includes taxes & fees
16 Apr - 17 Apr
Wingate by Wyndham St. Louis/Fenton Route 66
Exterior

WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon
2.5 star property
St. Peters
8.8 out of 10, Excellent, (74 reviews)
"Nice hotel with good staff."
United States
Michael
The price is NZ$181
includes taxes & fees
14 Apr - 15 Apr
WoodSpring Suites St Peters-OFallon
Lobby

Drury Inn & Suites Southwest St. Louis

Drury Inn & Suites Southwest St. Louis
3.0 star property
Valley Park
9.6 out of 10, Exceptional, (1,011 reviews)
"Very clean place with great food and friendly staff. "
Canada
Kara
The price is NZ$223
includes taxes & fees
10 May - 11 May
Drury Inn & Suites Southwest St. Louis
Lobby

Best Western Plus Washington Hotel

Best Western Plus Washington Hotel
2.5 star property
Washington
9.2 out of 10, Wonderful, (671 reviews)
"Great stay and accommodations. The pool was very nice. "
United States
Shane
The price is NZ$252
includes taxes & fees
14 Apr - 15 Apr
Best Western Plus Washington Hotel
Premium bedding, desk, iron/ironing board, free WiFi

Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
O'Fallon
9.0 out of 10, Wonderful, (1,000 reviews)
"This was one of our best stays ever nice hot breakfast. Clean room nice staff will stay again "
United States
Lavania
The price is NZ$169
includes taxes & fees
5 May - 6 May
Sleep Inn & Suites O'Fallon MO - Technology Drive
43-inch LED TV with digital channels, TV

Comfort Inn & Suites St. Louis - O'Fallon

Comfort Inn & Suites St. Louis - O'Fallon
2.5 star property
O'Fallon
7.6 out of 10, Good, (1,003 reviews)
"Good spot and great location to visit with family "
United States
Ernest
The price is NZ$161
includes taxes & fees
10 May - 11 May
Comfort Inn & Suites St. Louis - O'Fallon
Free daily buffet breakfast

Best Western Plus Fenton

Best Western Plus Fenton
2.5 star property
Fenton
9.2 out of 10, Wonderful, (252 reviews)
"Easy parking, friendly staff, clean and comfy rooms. "
United States
Jan
The price is NZ$195
includes taxes & fees
16 Apr - 17 Apr
Best Western Plus Fenton
Indoor pool

Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters
2.5 star property
St. Charles
8.0 out of 10, Very good, (1,002 reviews)
"Everything was great as always at this location as i have stayed here many times"
United States
Gregory
The price is NZ$225
includes taxes & fees
10 May - 11 May
Hampton Inn St. Charles St. Peters
Exterior

Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG
2.5 star property
Wentzville
9.4 out of 10, Exceptional, (890 reviews)
"Great location, clean, modern, killer shower and good bed! I would definitely recommend!"
United States
John
The price is NZ$284
includes taxes & fees
26 Apr - 27 Apr
Holiday Inn Express & Suites Wentzville St Louis West by IHG
Premium bedding, desk, iron/ironing board, free cots/infant beds

Super 8 by Wyndham St Charles

Super 8 by Wyndham St Charles
2.0 star property
St. Charles
8.0 out of 10, Very good, (1,002 reviews)
"Hotel was clean. Located in a good area, would stay here again. "
United States
Christy
The price is NZ$166
includes taxes & fees
26 Apr - 27 Apr
Super 8 by Wyndham St Charles
Lobby lounge

Fairfield Inn & Suites Wentzville

Fairfield Inn & Suites Wentzville
3.0 star property
Wentzville
9.0 out of 10, Wonderful, (667 reviews)
"Property was nice, easy check-in, nice breakfast, room was clean."
United States
Doris
The price is NZ$251
includes taxes & fees
15 Apr - 16 Apr
Fairfield Inn & Suites Wentzville
Property entrance

The Wildwood Hotel

The Wildwood Hotel
3.5 star property
Wildwood
9.2 out of 10, Wonderful, (1,627 reviews)
"Staff was wonderful, location is great for our needs, and it was a quiet stay-which we loved. "
United States
Jessica
The price is NZ$177
includes taxes & fees
12 Apr - 13 Apr
The Wildwood Hotel
Lobby

Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters
3.0 star property
St. Peters
9.4 out of 10, Exceptional, (1,010 reviews)
"Great stay! Very clean and staff was very nice. Definitely will be staying there on my return visit to the area!"
United States
Roxanne
The price is NZ$225
includes taxes & fees
10 May - 11 May
Drury Inn & Suites St. Louis St. Peters
Lobby

Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Chesterfield
3.0 star property
Chesterfield
9.6 out of 10, Exceptional, (1,125 reviews)
"It’s a great place very happy!"
United States
Chris
The price is NZ$271
includes taxes & fees
15 Apr - 16 Apr
Drury Plaza Hotel St. Louis Chesterfield
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Stay near popular Defiance attractions

Photo by Pages of Travel
Open Photo by Pages of Travel

Chandler Hill Vineyards

This elegant Missouri winery showcases local and California wines from its hillside setting. Savour varietals on the expansive terrace while enjoying vineyard views and seasonal cuisine from their full-service kitchen.
See properties
Wetlands landscape with a bird blind and cloudy sky reflected in a lake at the August A. Busch Memorial Conservation Area in St. Charles County Missouri

August A. Busch Memorial Conservation Area

This sprawling conservation area features over 30 lakes and historic WWII bunkers amid diverse habitats. Explore well-maintained trails while watching for migratory birds and wildlife in their natural environment.
See properties

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

See all hotels in Defiance
A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

Top Defiance Hotel Reviews

Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Chesterfield

10/10 Excellent
"Ever"
Chris 2-night trip
Posted 1 hour ago
Drury Plaza Hotel St. Louis Chesterfield

More cheap accommodation in Defiance

Relax Inn Saint Charles

Relax Inn Saint Charles

3800 Harry S Truman Blvd St. Charles MO
The price is NZ$121 per night from 10 May to 11 May
NZ$121
10 May - 11 May
includes taxes & fees
6.8/10 (1,001 reviews)

Frequently asked questions

What's the best place to stay in Defiance?
Hollywood Casino & Hotel St. Louis, located 18.1 mi (29.2 km) from the heart of Defiance, is a top choice for your stay, based on our traveller data. Two other options for your visit to the area are Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham and The Wildwood Hotel. See all available top hotels, or vacation rentals in Defiance.
What are some of the best holiday rentals that Defiance has to offer?
St. Charles 1860's Gem - Sleeps 6!: This holiday home rental outside of Defiance is located on a river, and has a garden, a selection of books and air conditioning to put you at ease in your new surroundings. Kitchen amenities include a dishwasher, a fridge and a stovetop. See all vacation rentals in Defiance.
If I need to cancel my hotel reservation in Defiance, will I receive a refund?
Yes! The majority of room reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.
What are some accommodation options with pools in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham: Offers an indoor pool, an outdoor pool and buffet. The Wildwood Hotel and Ameristar Casino Resort and Spa are two additional hotels with an on-site pool. View all hotels with pools in Defiance.
How is it staying in Defiance?
Visitors can enjoy all that Defiance has to offer, including the wineries and parks. Top sights in the area include St. Louis Union Station, Enterprise Center and Busch Stadium. In Defiance, there are 19 hotels and other accommodation options to choose from. Find out more about Defiance.
What should I do while I'm visiting Defiance?
Natural beauty is on display at Matson Hill Park Trailhead, August A. Busch Memorial Conservation Area and Missouri River. A couple of additional sights to add to your itinerary are Chandler Hill Vineyards and Historic Daniel Boone Home and Heritage Center. Take a look at what more there is to see and do in Expedia's Defiance guide.
What's the weather like in Defiance?
The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.

Explore a world of travel with Expedia