Serra Highlands Hotels, San Francisco

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
22 Dec - 23 Dec
Tomorrow
23 Dec - 24 Dec
This weekend
26 Dec - 28 Dec
Next weekend
2 Jan - 4 Jan

Filter by

Guest rating
Guest rating
Star rating

Our guide on where to stay in Serra Highlands

Find the best Serra Highlands areas for the activities you enjoy most. Learn more about Serra Highlands
Learn more about Serra Highlands
Union Square which includes a skyscraper and a city

Union Square

Fashion puts its best foot forward in one of America’s largest shopping plazas.

Downtown San Francisco

Known for its fascinating museums, popular shops and acclaimed art galleries, there's plenty to explore in Downtown San Francisco. Top attractions like Oracle Park and Chase Center are major draws. Catch the metro at Market St & 5th St Stop or Market St & Taylor St Stop to see more of the city.

Fisherman\'s Wharf showing a bay or harbour

Fisherman's Wharf

Taste some of the city’s freshest sea food and catch some fabulous views in this waterfront neighbourhood dating back to the time of the gold rush.

South of Market which includes skyline, a city and a garden

South of Market

From baseball games to top-notch art exhibits, find endless entertainment in one of San Francisco’s fastest-growing neighborhoods.

Nob Hill which includes a city and street scenes

Nob Hill

Examine architecturally significant buildings, visit the Cable Car Museum and enjoy magnificent views of greater San Francisco in this affluent district.

Top Serra Highlands Hotel Reviews

Fairmont San Francisco

Fairmont San Francisco

10/10 Excellent
"Staff is great and received an unexpected upgrade!"
Robert 1-night trip
Posted 19 hours ago
Fairmont San Francisco

Frequently asked questions

What is Serra Highlands like?
Travellers to South San Francisco's Serra Highlands neighbourhood will be sure to enjoy a stay here.
How many hotels will I find in the Serra Highlands area?
Book one of Expedia's 5 hotels and other accommodation options in Serra Highlands and start exploring everything South San Francisco has to offer.
If I need to cancel my hotel reservation in Serra Highlands, will I receive a refund?
Yes, you'll find most hotel bookings are fully refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If your reservation is non-refundable, you might be able to still cancel and receive a refund within a 24-hour period of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to review the best deals in Serra Highlands.
What is there to do in this South San Francisco neighbourhood?
Cypress Lawn Memorial Park, Hills of Eternity Memorial Park and Wyatt Earp's Grave are just a few of the places to visit in and around Serra Highlands. While you're out sightseeing, Pet's Rest Cemetery and Serramonte Center are a couple of additional sights to visit in South San Francisco.