The best area to stay in Santa Fe is the city centre, particularly around the Bulevar Gálvez and Avenida Alem.The city centre is the main hub for visitors, offering a mix of historic sites, dining, and shopping. Bulevar Gálvez is a wide, tree-lined avenue known for its elegant architecture and proximity to many of the city's main attractions, including the Provincial Historical Museum and the main square, Plaza 25 de Mayo. Avenida Alem runs parallel to the Paraná River, providing pleasant views and access to the waterfront.Couples often find this area ideal for a romantic and cultural trip. The central location allows for easy strolls to historic churches, art galleries, and a wide selection of restaurants, from traditional Argentine steakhouses to more contemporary eateries. Many hotels in this area also offer excellent amenities, including rooftop pools and high-end fitness equipment.For travellers interested in a mix of city exploration and river activities, the area around Avenida Alem is particularly good. It's close to the city's port, where you can find boat tours along the Paraná River, and offers a relaxed riverside atmosphere with cafes and parks.