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Check prices for these dates

Tonight
23 Sept - 24 Sept
Tomorrow
24 Sept - 25 Sept
This weekend
25 Sept - 27 Sept
Next weekend
2 Oct - 4 Oct

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Our top choices for Puxico hotels

1. Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
Poplar Bluff
United States
Rhonda
NZ$173
includes taxes & fees
18 Oct - 19 Oct
Hampton Inn Poplar Bluff

2. Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
Poplar Bluff
United States
Vicki
NZ$200
includes taxes & fees
5 Oct - 6 Oct
Fairfield Inn & Suites by Marriott Poplar Bluff

3. Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
Poplar Bluff
United States
Dean
NZ$193
includes taxes & fees
18 Oct - 19 Oct
Drury Inn & Suites Poplar Bluff

4. Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter
Dexter
United States
Kendall
NZ$191
includes taxes & fees
4 Oct - 5 Oct
Hampton Inn By Hilton Dexter

5. Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG
Poplar Bluff
United States
Nathan
NZ$165
includes taxes & fees
25 Oct - 26 Oct
Holiday Inn Poplar Bluff by IHG

6. Travelodge by Wyndham Dexter

Travelodge by Wyndham Dexter
Dexter
United States
Steven
NZ$186
includes taxes & fees
1 Oct - 2 Oct
Travelodge by Wyndham Dexter

7. Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
Poplar Bluff
United States
Cindy
NZ$145
includes taxes & fees
28 Sept - 29 Sept
Motel 6 Poplar Bluff, MO

8. Econo Lodge Dexter

Econo Lodge Dexter
Dexter
United States
Herman
NZ$101
includes taxes & fees
23 Oct - 24 Oct
Econo Lodge Dexter

9. Dexter Inn

Dexter Inn
Dexter
United States
Edward
NZ$133
includes taxes & fees
26 Sept - 27 Sept
Dexter Inn

10. Comfort Inn Poplar Bluff North

Comfort Inn Poplar Bluff North
Poplar Bluff
United States
Muhammad
NZ$165
includes taxes & fees
25 Oct - 26 Oct
Comfort Inn Poplar Bluff North

11. Lake Wappapello

Lake Wappapello
Williamsville
NZ$166
includes taxes & fees
26 Sept - 27 Sept
Lake Wappapello

12. OYO Hickory House Inn

OYO Hickory House Inn
Dexter
United States
Tammy
NZ$88
includes taxes & fees
7 Oct - 8 Oct
OYO Hickory House Inn

13. 40-acre Poplar Bluff Nature Lovers Paradise!

40-acre Poplar Bluff Nature Lovers Paradise!
Poplar Bluff
United States
Anonymous traveller
NZ$518
includes taxes & fees
25 Sept - 26 Sept
40-acre Poplar Bluff Nature Lovers Paradise!

14. Super 8 by Wyndham Poplar Bluff Missouri

Super 8 by Wyndham Poplar Bluff Missouri
Poplar Bluff
United States
Diana
NZ$109
includes taxes & fees
15 Oct - 16 Oct
Super 8 by Wyndham Poplar Bluff Missouri

15. EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
Marble Hill
United States
JANEEN
NZ$184
includes taxes & fees
11 Oct - 12 Oct
EC Reed's Mercantile and Hotel
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Learn more about Puxico

Head to sights like Mark Twain National Forest and Mingo Wilderness as you discover Puxico.

See all hotels in Puxico
A night scene with a clear sky, a crescent moon, and two silhouetted trees against a twilight sky.
Photo by Mike McClain

Top Puxico Hotel Reviews

Recent Reviews in Puxico

Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

10/10 Excellent
"Clean room, staff"
Lavonne 2-night trip
Posted 1 day ago
Drury Inn & Suites Poplar Bluff
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

10/10 Excellent
"Easy checkin, clean facilities, safe area. Quiet with a comfy bed."
Deandra 1-night trip
Posted 2 days ago
Motel 6 Poplar Bluff, MO
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

10/10 Excellent
"It was a great experience."
JESUS M 1-night trip
Posted 3 days ago
Hampton Inn Poplar Bluff
Super 8 by Wyndham Poplar Bluff Missouri

Super 8 by Wyndham Poplar Bluff Missouri

10/10 Excellent
"Clean room. Would liked to of had a trash can in the room. But that didn't affect our stay."
Patricia 1-night trip
Posted 3 days ago
Super 8 by Wyndham Poplar Bluff Missouri
EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel

10/10 Excellent
"Quiet and comfy. Great price."
Brandon 1-night trip
Posted 4 days ago
EC Reed's Mercantile and Hotel
Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter

8/10 Good
"Very nice hotel - our favorite when we visit the grandkids! Our only issue this time was with housekeeping. We arrived Friday afternoon, asked that our room be serviced on Sunday, (they only do it every other day), and it was not done. Also, in the shower were the usual shampoo and shower gel, but instead of conditioner, the 3rd dispenser was body lotion! I asked if the lotion could be replaced with conditioner - didn’t happen. Disappointed!"
Paul 3-night trip
Posted 9 days ago
Hampton Inn By Hilton Dexter
Lake Wappapello

Lake Wappapello

10/10 Excellent
"This a cabin in a state park. It was very clean and had newer upgrades. Bring the food you need because it's fairly distance from a grocery. We came later in the day because we needed one night and this was a great price and not a chain hotel which we like. There is a little store not too far from the park. We ordered deli sandwiches from here and picked up some icecream. The sandwiches were delicious and the store had pretty much whatever you might need. The checkin process was great with good communication about which cabin to go to, what the door code was etc... We plan to come back for a longer stay so we can have another evening around the firepit and see all of the stars. Great place to stay."
Dottie 1-night trip
Posted 2 weeks ago
Lake Wappapello
Secluded in the woods, couple’s romantic cabin & hot tub, brkfast foods provided

Secluded in the woods, couple’s romantic cabin & hot tub, brkfast foods provided

10/10 Excellent
"My wife and I stayed here for anniversary trip. The fox den is a perfect combination of 1970's vibes, while still having modern conveniences. We appreciated the fresh eggs provided and well stocked kitchen for making breakfast.The host put much effort in making sure it was great experience with great guidebook that provided information on everything in the fox den and recommended local places for dining and exploring. We also had the charcuterie add-on, which looked and tasted amazing and was perfect for snacking on during our stay.The location is very secluded as described. My only advice would be to plan your excursions from the fox den as it does take some extra travel time (especially if you normally live in more populated areas) than what you may be used to. That being said the natural beauty of the area, along with the peace and quiet was worth the extra distance. Overall, we had a great stay and would recommend the fox den to anyone looking for escape into both nature and the 1970's."
Stephen J. 2-night trip
Posted 2 months ago
Secluded in the woods, couple’s romantic cabin & hot tub, brkfast foods provided
Private lake, beach & hot tub,  romantic getaway or family vaca

Private lake, beach & hot tub, romantic getaway or family vaca

8/10 Good
"Great location to access the lake close by. Very picturesque location.Pics are a lil deceiving in that things are actually on a smaller scale IRL but still good amenities.Be aware, the pond is not swimmable but paddle boat is fun."
BELINDA W. 11-night trip
Posted 2 months ago
Private lake, beach & hot tub, romantic getaway or family vaca

More cheap accommodation in Puxico

Econo Lodge Dexter

Econo Lodge Dexter

913 Outer Rd Dexter MO
NZ$101
23 Oct - 24 Oct
includes taxes & fees
6.8/10 (283 reviews)
Econo Lodge Dexter
Super 8 by Wyndham Poplar Bluff Missouri

Super 8 by Wyndham Poplar Bluff Missouri

2831 N Westwood Blvd Poplar Bluff MO
NZ$109
15 Oct - 16 Oct
includes taxes & fees
6.6/10 (673 reviews)
Super 8 by Wyndham Poplar Bluff Missouri
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO
NZ$145
28 Sept - 29 Sept
includes taxes & fees
8/10 Very good! (1,000 reviews)
Motel 6 Poplar Bluff, MO
Comfort Inn Poplar Bluff North

Comfort Inn Poplar Bluff North

2582 N Westwood Blvd Poplar Bluff MO
NZ$165
25 Oct - 26 Oct
includes taxes & fees
Comfort Inn Poplar Bluff North
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

2420 Crestwood Dr Poplar Bluff MO
NZ$173
18 Oct - 19 Oct
includes taxes & fees
9.4/10 Exceptional! (949 reviews)
Hampton Inn Poplar Bluff
Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter

2179 Gill Plaza Drive Dexter MO
NZ$191
4 Oct - 5 Oct
includes taxes & fees
9.6/10 Exceptional! (71 reviews)
Hampton Inn By Hilton Dexter

Frequently asked questions

When is the best time to go to Puxico?
The best time to visit Puxico, Missouri, is during the spring (late April to early June) and autumn (September to October) months.These periods offer pleasant weather, with comfortable temperatures and generally less humidity, making it ideal for outdoor activities and exploring the local area. Spring brings blooming dogwoods and redbuds, while autumn showcases beautiful fall foliage, particularly in the surrounding Mingo National Wildlife Refuge.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, although it depends on the cancellation policy of your booking. Most bookings are refundable if cancelled within 24 to 48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to 'My Trips' and selecting your reservation. To find flexible deals, filter your search by 'Fully refundable property' for hotels in Puxico.
How can I save on a hotel booking in Puxico with Expedia?
One Key™—Expedia's free travel rewards program—gives you instant access to discounts with Member Prices on Puxico hotels. Plus, you'll earn OneKeyCash™* on eligible bookings to use on future trips. Booking an Expedia hotel and flight package is another great way to save, where bundling can result in significant savings. *Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
How much is the nightly rate for a hotel in Puxico?
Prices for hotels in Puxico often vary, but you can find a great deal from NZ$88 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by 'Price: low to high' for our cheapest rates.

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