A night scene with a clear sky, a crescent moon, and two silhouetted trees against a twilight sky.

Search Puxico hotels

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
8 Aug - 9 Aug
Tomorrow
9 Aug - 10 Aug
Next weekend
14 Aug - 16 Aug
In two weeks
21 Aug - 23 Aug

Filter by

Property class

Guest rating

Our top choices for Puxico hotels

Breakfast included
Hotel
Reserve now, pay later
Mingo Wilderness
Pet-friendly
Lobby
Lobby
Pool
Exterior

1. Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter
Dexter
United States
Vanessa
NZ$186
includes taxes & fees
16 Aug - 17 Aug
Hampton Inn By Hilton Dexter
Lobby
Indoor pool, outdoor pool
Lobby
Suite, 2 Queen Beds, Accessible (Sofa Sleeper, Tub, 2 Rooms)

2. Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
Poplar Bluff
United States
Elaine
NZ$180
includes taxes & fees
16 Aug - 17 Aug
Drury Inn & Suites Poplar Bluff
Lobby
Property amenity
Property amenity
Property amenity

3. Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
Poplar Bluff
United States
Jean
NZ$194
includes taxes & fees
16 Aug - 17 Aug
Fairfield Inn & Suites by Marriott Poplar Bluff
Free daily buffet breakfast
Snack bar
Terrace/patio
Indoor pool

4. Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
Poplar Bluff
United States
Philip
NZ$183
includes taxes & fees
6 Sept - 7 Sept
Hampton Inn Poplar Bluff
Coffee service
Private kitchenette
Lobby
Front of property

5. Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
Poplar Bluff
United States
Kathleen
NZ$137
includes taxes & fees
10 Aug - 11 Aug
Motel 6 Poplar Bluff, MO
Breakfast area
Breakfast area
Free WiFi, bed sheets
Reception

6. Dexter Inn

Dexter Inn
Dexter
United States
Cynthia
NZ$116
includes taxes & fees
23 Aug - 24 Aug
Dexter Inn
Breakfast, lunch and dinner served
Lobby
Fitness facility
Lobby

7. Travelodge by Wyndham Dexter

Travelodge by Wyndham Dexter
Dexter
United States
Steven
NZ$175
includes taxes & fees
23 Aug - 24 Aug
Travelodge by Wyndham Dexter
Breakfast, lunch and dinner served
Exterior
Exterior
Breakfast, lunch and dinner served

8. Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG
Poplar Bluff
United States
ASHTON
NZ$178
includes taxes & fees
23 Aug - 24 Aug
Holiday Inn Poplar Bluff by IHG
Lobby
Free daily buffet breakfast
Desk, rollaway beds, free WiFi, alarm clocks
Exterior

9. Comfort Inn Poplar Bluff North

Comfort Inn Poplar Bluff North
Poplar Bluff
United States
Muhammad
NZ$159
includes taxes & fees
30 Aug - 31 Aug
Comfort Inn Poplar Bluff North
Desk, iron/ironing board, free WiFi, bed sheets
Lobby
Exterior
Desk, iron/ironing board, free WiFi, bed sheets

10. Econo Lodge Dexter

Econo Lodge Dexter
Dexter
United States
Herman
NZ$97
includes taxes & fees
7 Sept - 8 Sept
Econo Lodge Dexter
Desk, iron/ironing board, free WiFi, bed sheets
Room, 2 Queen Beds, Non Smoking | Bathroom
Reception
Property entrance

11. OYO Hickory House Inn

OYO Hickory House Inn
Dexter
United States
Tammy
NZ$94
includes taxes & fees
22 Aug - 23 Aug
OYO Hickory House Inn
In-room safe, desk, free WiFi, bed sheets
Lobby
Exterior
Laundry room

12. Super 8 by Wyndham Poplar Bluff Missouri

Super 8 by Wyndham Poplar Bluff Missouri
Poplar Bluff
United States
Diana
NZ$130
includes taxes & fees
22 Aug - 23 Aug
Super 8 by Wyndham Poplar Bluff Missouri
Front of property
Exterior
Cabin
Front of property

13. Lake Wappapello

Lake Wappapello
Williamsville
United States
Tonya
NZ$137
includes taxes & fees
10 Aug - 11 Aug
Lake Wappapello
Lobby sitting area
Exterior
Deluxe Double Room
Restaurant

14. EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
Marble Hill
United States
JANEEN
NZ$143
includes taxes & fees
11 Aug - 12 Aug
EC Reed's Mercantile and Hotel
View all properties
Save an average of 15% on thousands of hotels when you're signed in

Learn more about Puxico

Head to sights like Mark Twain National Forest and Mingo Wilderness as you discover Puxico.

See all hotels in Puxico
A night scene with a clear sky, a crescent moon, and two silhouetted trees against a twilight sky.
Photo by Mike McClain

Top Puxico Hotel Reviews

Recent Reviews in Puxico

Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

10/10 Excellent
"Excellent stay and Staff!"
Teresa 1-night trip
Posted 8 hours ago
Drury Inn & Suites Poplar Bluff
Comfort Inn Poplar Bluff North

Comfort Inn Poplar Bluff North

8/10 Good
"F"
Lori 2-night trip
Posted 1 day ago
Comfort Inn Poplar Bluff North
Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

10/10 Excellent
"Good hotel. Great breakfast"
Michael 1-night trip
Posted 3 days ago
Holiday Inn Poplar Bluff by IHG
Super 8 by Wyndham Poplar Bluff Missouri

Super 8 by Wyndham Poplar Bluff Missouri

10/10 Excellent
"Great stay helpful people"
Jaden 1-night trip
Posted 5 days ago
Super 8 by Wyndham Poplar Bluff Missouri
Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter

10/10 Excellent
"During summer time, don’t park behind the building. There’s a pond in the distance and the light draws a TON of mosquitoes there, but the other entrances are all fine. The pond makes for a beautiful view with ducks and cranes, though. Everything about the bed was heavenly. Send the whole thing to my house, pronto! LOL The supplied shower body gel, shampoo, conditioner, and body lotion by Zero% is to die for! Smells great, super moisturizing, and good for the planet? Wow! The free breakfast was awesome! Waffles and fresh oatmeal with a HUGE variety of toppings, cereal and milk, juices, coffees and teas with sweeteners, sugars, creams, and real honey, cocoa, yogurt, boiled eggs, scrambled eggs, bacon, sausage, ranch potatoes, bagels (soft!), muffins, scones, toast and all the spreads for them, fresh fruit… what more could you need FOR FREE? Love love love the packaged reusable/disposable coffee pod holder for the coffee maker in the room. No more worrying if it was cleaned, cleaned properly, or used to wash someone’s underwear beforehand. Water pressure, shower head, and temperature was just right. I wish the light would stay on during the shower, though. And even with the door barely ajar the light and fan was still kicking on when I wasn’t in the bathroom. I was in the bed. Alone. Air conditioner/heater is a vast improvement from the old style in other hotels. It has a wall control just like home! The TV is giant! Anyway, will absolutely be back more than once. Thank you!"
Dawn 1-night trip
Posted 5 days ago
Hampton Inn By Hilton Dexter
Cozy hobby farm cabin under the stars!

Cozy hobby farm cabin under the stars!

10/10 Excellent
"Our second visit"
Anonymous traveller 2-night trip
Posted 6 days ago
Cozy hobby farm cabin under the stars!
Travelodge by Wyndham Dexter

Travelodge by Wyndham Dexter

8/10 Good
"Lean room. Very basic. Some sort of breakfast would had been nice. Overall is was good. Great price"
Kenneth 1-night trip
Posted 9 days ago
Travelodge by Wyndham Dexter
OYO Hickory House Inn

OYO Hickory House Inn

10/10 Excellent
"Nice for overnight stop"
Tammy 1-night trip
Posted 10 days ago
OYO Hickory House Inn
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

10/10 Excellent
"The property was very well maintained. Staff was very friendly. Very clean. Only complaint was cleaning ladies threw away a razor my daughter had in shower. It was not a disposable one. They could have just left it where it was."
Aluce 3-night trip
Posted 11 days ago
Hampton Inn Poplar Bluff

More cheap accommodation in Puxico

Super 8 by Wyndham Poplar Bluff Missouri

Super 8 by Wyndham Poplar Bluff Missouri

2831 N Westwood Blvd Poplar Bluff MO
NZ$130
22 Aug - 23 Aug
includes taxes & fees
6.6/10 (663 reviews)
Super 8 by Wyndham Poplar Bluff Missouri
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO
NZ$137
10 Aug - 11 Aug
includes taxes & fees
Motel 6 Poplar Bluff, MO
Comfort Inn Poplar Bluff North

Comfort Inn Poplar Bluff North

2582 N Westwood Blvd Poplar Bluff MO
NZ$159
30 Aug - 31 Aug
includes taxes & fees
7.8/10 Good! (431 reviews)
Comfort Inn Poplar Bluff North
Travelodge by Wyndham Dexter

Travelodge by Wyndham Dexter

1608 E Business US 60 Dexter MO
NZ$175
23 Aug - 24 Aug
includes taxes & fees
7.6/10 Good! (419 reviews)
Travelodge by Wyndham Dexter
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

2420 Crestwood Dr Poplar Bluff MO
NZ$183
6 Sept - 7 Sept
includes taxes & fees
Hampton Inn Poplar Bluff
Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter

2179 Gill Plaza Drive Dexter MO
NZ$186
16 Aug - 17 Aug
includes taxes & fees
9.6/10 Exceptional! (62 reviews)
Hampton Inn By Hilton Dexter

Frequently asked questions

When is the best time to go to Puxico?
The best time to visit Puxico, Missouri, is during the spring (late April to early June) and autumn (September to October) months.These periods offer pleasant weather, with comfortable temperatures and generally less humidity, making it ideal for outdoor activities and exploring the local area. Spring brings blooming dogwoods and redbuds, while autumn showcases beautiful fall foliage, particularly in the surrounding Mingo National Wildlife Refuge.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, although it depends on the cancellation policy of your booking. Most bookings are refundable if cancelled within 24 to 48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to 'My Trips' and selecting your reservation. To find flexible deals, filter your search by 'Fully refundable property' for hotels in Puxico.
How can I save on a hotel booking in Puxico with Expedia?
One Key™—Expedia's free travel rewards program—gives you instant access to discounts with Member Prices on Puxico hotels. Plus, you'll earn OneKeyCash™* on eligible bookings to use on future trips. Booking an Expedia hotel and flight package is another great way to save, where bundling can result in significant savings. *Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
How much is the nightly rate for a hotel in Puxico?
Prices for hotels in Puxico often vary, but you can find a great deal from NZ$94 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by 'Price: low to high' for our cheapest rates.

Explore a world of travel with Expedia