The Reynolds Homestead, built in 1943 is in a beautiful foothill setting. Hardin Reynolds and his wife produced 16 children here, the most famous being RJ Reynolds who migrated to Winston Salem, NC to start the tobacco empire of the same name. The catalpa tree in the foreground still remains from the earliest days of the homestead.

Search Lodges in Mayo River

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Next weekend

In two weeks

In one month

In two months

Our top choices for Mayo River lodges

The Lodge at Primland, Auberge Collection

Meadows Of Dan

Melinda

includes taxes & fees

29 Jan - 30 Jan 2026

View all properties

Save an average of 15% on thousands of hotels when you're signed in

Top Mayo River Hotel Reviews

Hampton Inn Eden

10/10 Excellent

"We like to take a staycation in town sometimes for a change of scenery and this is the only hotel here we will use. The employees are always very friendly, the beds are comfortable, and the rooms are clean. Plenty of options to watch on tv or you can sign into Netflix. We didn’t make it to breakfast but love the 12pm checkout."