Top Hotels Near Mark Twain Medical Center in San Andreas from NZ$143

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
30 Dec - 31 Dec
Tomorrow
31 Dec - 1 Jan
This weekend
2 Jan - 4 Jan
Next weekend
9 Jan - 11 Jan

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Mark Twain Medical Center hotels

Exterior
Robins Nest Bed & Breakfast

Robins Nest Bed & Breakfast

Robins Nest Bed & Breakfast
3.5 star property
1.6 km from Mark Twain Medical Center
9.6 out of 10, Exceptional, (144)
"Very nice home well decorated with antiques. Breakfast was excellent. "
United States
John
The price is NZ$289
includes taxes & fees
1 Jan - 2 Jan 2026
Robins Nest Bed & Breakfast
Room, 1 Queen Bed, Kitchenette, Garden View (The Bonnie Inn Unit 6) | View from room
The Bonnie Inn Unit 6

The Bonnie Inn Unit 6

The Bonnie Inn Unit 6
3.0 star property
1.7 km from Mark Twain Medical Center
8.6 out of 10, Excellent, (9)
"I will definitely stay there again."
United States
Karyn
The price is NZ$301
includes taxes & fees
8 Jan - 9 Jan 2026
The Bonnie Inn Unit 6
Property grounds
The Bonnie Inn Unit 1

The Bonnie Inn Unit 1

The Bonnie Inn Unit 1
2.0 star property
1.7 km from Mark Twain Medical Center
8.6 out of 10, Excellent, (4)
"Very Cute Comfortable Room We had a nice visit "
United States
ERIK
The price is NZ$307
includes taxes & fees
5 Jan - 6 Jan 2026
The Bonnie Inn Unit 1
Outdoor pool
Hotel Leger

Hotel Leger

Hotel Leger
2.0 star property
12.7 km from Mark Twain Medical Center
The price is NZ$385
includes taxes & fees
1 Jan - 2 Jan 2026
Hotel Leger
Front of property
The 10th Green Inn

The 10th Green Inn

The 10th Green Inn
3.0 star property
14.3 km from Mark Twain Medical Center
8.0 out of 10, Very good, (112)
"Very cozy and wonderful location "
United States
Kristyn
The 10th Green Inn
Property amenity
Travelodge by Wyndham Angels Camp CA

Travelodge by Wyndham Angels Camp CA

Travelodge by Wyndham Angels Camp CA
2.0 star property
14.4 km from Mark Twain Medical Center
8.0 out of 10, Very good, (1000)
"Everything is great"
United States
Rafael
The price is NZ$144
includes taxes & fees
11 Jan - 12 Jan 2026
Travelodge by Wyndham Angels Camp CA
Premier Single Room, 1 King Bed, Non Smoking, Valley View | Terrace/patio
Courtwood Inn

Courtwood Inn

Courtwood Inn
3.5 star property
16.2 km from Mark Twain Medical Center
10.0 out of 10, Exceptional, (22)
"So peaceful and relaxing stay"
United States
Lita
The price is NZ$599
includes taxes & fees
14 Jan - 15 Jan 2026
Courtwood Inn
Lobby
Best Western Cedar Inn & Suites

Best Western Cedar Inn & Suites

Best Western Cedar Inn & Suites
2.5 star property
16.2 km from Mark Twain Medical Center
9.0 out of 10, Wonderful, (1002)
"Continental breakfast was great with lots of yummy options. Staff was very nice. Only bad thing is that the bed pillows were small and weird. If you stay here, bring your own pillows for sure."
United States
Kimberly
The price is NZ$201
includes taxes & fees
6 Jan - 7 Jan 2026
Best Western Cedar Inn & Suites
BBQ/picnic Area
Jumping Frog Motel

Jumping Frog Motel

Jumping Frog Motel
2.0 star property
15.9 km from Mark Twain Medical Center
7.2 out of 10, Good, (309)
"Jumping Frog provided a clean room and hot shower at a decent price. I would book here again"
United States
Terese
The price is NZ$143
includes taxes & fees
1 Jan - 2 Jan 2026
Jumping Frog Motel
Standard Single Room, 1 King Bed, Accessible, Refrigerator & Microwave
Angels Inn

Angels Inn

Angels Inn
2.5 star property
16.7 km from Mark Twain Medical Center
7.4 out of 10, Good, (803)
"Very clean, comfortable beds. Staff are very nice."
United States
Mariia
Angels Inn
Exterior
The Victoria Inn

The Victoria Inn

The Victoria Inn
3.5 star property
19 km from Mark Twain Medical Center
8.8 out of 10, Excellent, (201)
"Always love the stay at the Victoria Inn. Will be returning again soon!"
United States
Michelle
The price is NZ$312
includes taxes & fees
4 Jan - 5 Jan 2026
The Victoria Inn
In-room safe, desk, laptop workspace, blackout curtains
Holiday Inn Express Hotel & Suites Jackson by IHG

Holiday Inn Express Hotel & Suites Jackson by IHG

Holiday Inn Express Hotel & Suites Jackson by IHG
3.0 star property
18.8 km from Mark Twain Medical Center
8.2 out of 10, Very good, (577)
"Clean facilities rooms. Easy check in and out "
United States
Keith
The price is NZ$213
includes taxes & fees
11 Jan - 12 Jan 2026
Holiday Inn Express Hotel & Suites Jackson by IHG
Lobby
National Hotel Jackson, Tapestry Collection by Hilton

National Hotel Jackson, Tapestry Collection by Hilton

National Hotel Jackson, Tapestry Collection by Hilton
2.5 star property
19.7 km from Mark Twain Medical Center
9.4 out of 10, Exceptional, (1001)
"Everything was wonderful, staff, rooms, location Great holiday getaway"
United States
Marcia
The price is NZ$204
includes taxes & fees
6 Jan - 7 Jan 2026
National Hotel Jackson, Tapestry Collection by Hilton
Interior entrance
Murphys Suites

Murphys Suites

Murphys Suites
2.0 star property
19.8 km from Mark Twain Medical Center
9.0 out of 10, Wonderful, (1000)
"Great staff and great location - love the free soft serve ice cream in the lobby!"
United States
Stewart
Murphys Suites
Outdoor pool
Murphys Inn Motel

Murphys Inn Motel

Murphys Inn Motel
2.5 star property
19.6 km from Mark Twain Medical Center
8.6 out of 10, Excellent, (1002)
"Nice place to stay near Murphys Main Street"
United States
saurav
Murphys Inn Motel
Lobby
Best Western Amador Inn

Best Western Amador Inn

Best Western Amador Inn
2.5 star property
19.5 km from Mark Twain Medical Center
7.6 out of 10, Good, (1001)
"The entire overall experience was amazing"
United States
Stephen
The price is NZ$177
includes taxes & fees
4 Jan - 5 Jan 2026
Best Western Amador Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Mark Twain Medical Center Hotel Reviews

Angels Inn

Angels Inn

10/10 Excellent
"Very clean, comfortable beds. Staff are very nice."
Mariia 4-night trip
Posted 2 days ago
Angels Inn

Hotels near other Mark Twain Medical Center attractions

Calaveras County Museum Complex

3.5/5 (2 reviews)
You can spend an afternoon browsing the exhibits at Calaveras County Museum Complex during your trip to San Andreas. You can seek out the campsites while in the area.
See properties

Mokelumne Hill Library

After visiting Mokelumne Hill Library, make a plan to see the other sights and activities in Mokelumne Hill. Wander the riverfront in this relaxing area.
See properties

Frequently asked questions

What's the area like around Mark Twain Medical Center?
Mark Twain Medical Center is located in San Andreas. You'll find 11 hotels and other accommodations within a few miles for a convenient home base.
What's the best hotel to stay close to Mark Twain Medical Center?
Robins Nest Bed & Breakfast is one of the top choices for your stay based on our traveller data, and this B&B offers free breakfast and free parking. It's located just a short 1 mi (1.6 km) from Mark Twain Medical Center. Another good option is Sierra Inn, located just 0.8 mi (1.2 km) away.
How many hotels will I be able to find close to Mark Twain Medical Center?
Expedia has 11 hotels and other accommodation options a few miles from Mark Twain Medical Center.
If I need to cancel the hotel reservation for my stay near Mark Twain Medical Center, will I receive a refund?
Yes! Most hotel reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you have a reservation that's non-refundable, you may still be able to cancel and get a refund within 24 hours of your booking. Add dates, click "Search", then you can use the "fully refundable" filter to view the best options available near Mark Twain Medical Center.