Lyon is crossed by two rivers, running north to south and meeting just below the city, thus forming the Presqu'île - literally, the "almost an island". This, in turn, is cut across by the enormous complex of the train station with adjoining car park and coach/bus station. Main train stations are often dodgy places, and Lyon Perrache station is no exception. I have travelled a bit and don't often feel unsafe, but I whenever I had to cross the station after dark.
The hotel is located south of the station, which means that, to visit the city, you have to cross the train station on foot; if you're planning on using the underground, the nearest station is also in Perrache, so you can't really avoid it.
The hotel itself is quite reasonable for the price, though the common areas on the ground floor have been more carefully refurbished than at least some of the rooms. We stayed on the 7th floor, facing the river Rhône. The rooms on this side were tiny (even by European standards), and the bed - which indeed was very comfortable - filled it so that you barely could go around it. I noticed that the rooms on the other side of the corridor were more spacious, but probably had no view to speak of. The bathroom was functional and clean, and had been recently refurbished. There was a kettle and complimentary tea and coffee. The windows were efficiently soundproof, which is something to be thankful for, as there is a busy highway running along the river from the station area.
The hotel staff were friendly and helpfu. We didn't try breakfast, as € 8,5 per person seemed too much for our appetites.
On the whole, I wouldn't recommend the area of Lyon Perrache for your visit, especially because of the station issue. However, if you don't have a problem with that, or if you're driving, this may be a good spot. Considering the price, Kyrriad Lyon Perrache can be a good solution for you. And you're not far from Brasserie Georges, which definitely is a must-go!