South Central Houston Hotels, Houston

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15 Nov - 16 Nov
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16 Nov - 17 Nov
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20 Nov - 22 Nov
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27 Nov - 29 Nov

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Our top choices for South Central Houston hotels

A rooftop pool area with lounge chairs and a view of a tall building at night.

1. The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
4.0 star property
South Central Houston
9.2 out of 10, Wonderful, (1,288 reviews)
"Great location and wonderful staff!"
United States
Cynthia
The price is NZ$254
includes taxes & fees
21 Nov - 22 Nov
The Westin Houston Medical Center/Museum District
A modern hotel room with a large bed, a black leather sofa, a wooden coffee table, and a desk with a mirror.

2. Downtowner Inns - Houston Downtown

Downtowner Inns - Houston Downtown
2.0 star property
South Central Houston
9.2 out of 10, Wonderful, (282 reviews)
"Great place and close to downtown."
United States
Israel
The price is NZ$193
includes taxes & fees
17 Nov - 18 Nov
Downtowner Inns - Houston Downtown
A rooftop patio with outdoor seating, fire pits, and a view of the cityscape.

3. Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
South Central Houston
8.6 out of 10, Excellent, (2,259 reviews)
"Very nice, would stay again!"
United States
Amanda
The price is NZ$199
includes taxes & fees
23 Nov - 24 Nov
Hilton Houston Plaza/Medical Center
A modern hotel building with a prominent entrance, large windows, and a visible name sign.

4. InterContinental Houston by IHG

InterContinental Houston by IHG
4.0 star property
South Central Houston
9.4 out of 10, Exceptional, (1,009 reviews)
"Great stay!"
United States
Luke
The price is NZ$358
includes taxes & fees
22 Nov - 23 Nov
InterContinental Houston by IHG
A spacious dining area with multiple tables and chairs, large windows, and hanging pendant lights.

5. DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites
4.0 star property
South Central Houston
8.4 out of 10, Very good, (724 reviews)
"Great stay in the medical center. I would stay here again - love the fitness center."
United States
Alexia
The price is NZ$241
includes taxes & fees
22 Nov - 23 Nov
DoubleTree by Hilton Houston Medical Center Hotel & Suites
A modern restaurant with a bar area, featuring a patterned floor, multiple dining tables, and contemporary lighting fixtures.

6. Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District
4.0 star property
South Central Houston
9.0 out of 10, Wonderful, (1,000 reviews)
"Location was best"
United States
Nafisa
The price is NZ$380
includes taxes & fees
22 Nov - 23 Nov
Houston Marriott Medical Center/Museum District
A multi-story hotel with a brick facade, balconies, and a well-lit entrance.

7. La Maison in Midtown an urban B&B

La Maison in Midtown an urban B&B
3.5 star property
South Central Houston
9.8 out of 10, Exceptional, (612 reviews)
"Lovely hotel, run by staff who go out of their way to make your stay easy and enjoyable."
United States
Paul
The price is NZ$368
includes taxes & fees
17 Nov - 18 Nov
La Maison in Midtown an urban B&B
A modern kitchen with dark wood cabinets, a granite countertop, and a built-in island with a glass enclosure.

8. Americas Best Value Inn Medical Center Downtown

Americas Best Value Inn Medical Center Downtown
2.0 star property
South Central Houston
8.0 out of 10, Very good, (1,003 reviews)
"Great Stay"
United States
Randy
The price is NZ$184
includes taxes & fees
16 Nov - 17 Nov
Americas Best Value Inn Medical Center Downtown
A spacious living area with a dining table, chairs, and a chandelier.

9. Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
4.5 star property
South Central Houston
9.2 out of 10, Wonderful, (1,021 reviews)
"Courteous staff, conveniently located. Very good amenities."
United States
David
The price is NZ$494
includes taxes & fees
22 Nov - 23 Nov
Hotel Zaza Houston Museum District
A high-rise hotel with a rooftop pool, multiple floors, and a cityscape view.

10. Sentral Forme Houston

Sentral Forme Houston
4.5 star property
South Central Houston
9.2 out of 10, Wonderful, (102 reviews)
"Enjoyable stay with all the comforts of home."
United States
ebony noelle
The price is NZ$453
includes taxes & fees
13 Dec - 14 Dec
Sentral Forme Houston
Private kitchen

11. 2824 Aeon Living

2824 Aeon Living
3.5 star property
South Central Houston
The price is NZ$247
includes taxes & fees
22 Nov - 23 Nov
2824 Aeon Living
A modern kitchen with a large island, bar stools, and a stainless steel refrigerator.

12. Wanderstay Boutique Hotel

Wanderstay Boutique Hotel
3.0 star property
South Central Houston
9.6 out of 10, Exceptional, (85 reviews)
"Everything about our stay here was wonderful."
United States
jennifer k
The price is NZ$285
includes taxes & fees
17 Nov - 18 Nov
Wanderstay Boutique Hotel
A spacious lobby with a large sectional sofa, a coffee table, and a reception desk.

13. Hilton University of Houston

Hilton University of Houston
3.5 star property
South Central Houston
9.0 out of 10, Wonderful, (1,001 reviews)
"Great stay!"
United States
Elizabeth
The price is NZ$311
includes taxes & fees
23 Nov - 24 Nov
Hilton University of Houston
A large, multi-story house with a swimming pool, outdoor seating, and a red umbrella.

14. Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only

Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
3.5 star property
South Central Houston
9.6 out of 10, Exceptional, (223 reviews)
"The room was very clean, the staff was just great and the breakfast was very good! The Parking was a little difficult, but it was very safe!"
United States
Walter
The price is NZ$465
includes taxes & fees
17 Nov - 18 Nov
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
A hotel room with a bed, a desk, a chair, a mirror, a television, and a heater.

15. Scott Inn Suites - Downtown Houston

Scott Inn Suites - Downtown Houston
2.0 star property
South Central Houston
8.4 out of 10, Very good, (50 reviews)
"It was close to downtown, easily accessible from the convention center and the host was pretty helpful"
United States
Daniel
The price is NZ$140
includes taxes & fees
23 Nov - 24 Nov
Scott Inn Suites - Downtown Houston
A hotel room with a bed, bedside table, desk, and a mirror.

16. Southmore Boulevard Motel

Southmore Boulevard Motel
2.0 star property
South Central Houston
5.8 out of 10, (245 reviews)
"Very sweet lady I will be back"
United States
LaKeara
The price is NZ$124
includes taxes & fees
16 Nov - 17 Nov
Southmore Boulevard Motel
A spacious lobby with a high ceiling, a central seating area with sofas and armchairs, a staircase leading to an upper level, and a flat-screen TV mounted on the wall.

17. Extended Stay America Suites Houston Med Ctr Braeswood Bl

Extended Stay America Suites Houston Med Ctr Braeswood Bl
2.5 star property
South Central Houston
6.2 out of 10, (1,006 reviews)
"The perfect place to stay!"
Mexico
Maria Fernanda
The price is NZ$143
includes taxes & fees
13 Dec - 14 Dec
Extended Stay America Suites Houston Med Ctr Braeswood Bl
A large outdoor swimming pool with a slide and multiple lanes, surrounded by a modern building with large windows.

18. Historic Loft - 2 I NRG Medcenter Dtown Fifa

Historic Loft - 2 I NRG Medcenter Dtown Fifa
2.0 star property
South Central Houston
The price is NZ$396
includes taxes & fees
18 Nov - 19 Nov
Historic Loft - 2 I NRG Medcenter Dtown Fifa
A modern reception area with a blackboard, a blue sofa, a yellow armchair, and a colorful rug.

19. Wanderstay Houston Hostel

Wanderstay Houston Hostel
2.0 star property
South Central Houston
8.2 out of 10, Very good, (222 reviews)
"Horrible do not stay here."
United States
Nathalia
The price is NZ$102
includes taxes & fees
16 Nov - 17 Nov
Wanderstay Houston Hostel
A modern kitchen with dark cabinets, a stainless steel refrigerator, and a microwave.

20. Houston Lux Townhome

Houston Lux Townhome
2.0 star property
South Central Houston
9.8 out of 10, Exceptional, (10 reviews)
"The proximity to places we wanted to go was very close."
United States
Bobbi
The price is NZ$500
includes taxes & fees
1 Dec - 2 Dec
Houston Lux Townhome
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in South Central Houston

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A multi-story hotel with a brick facade, balconies, and a well-lit entrance.
La Maison in Midtown an urban B&B
3.5 star property
9.8
Exceptional
612 reviews
View
A modern kitchen with dark cabinets, a stainless steel refrigerator, and a microwave.
Houston Lux Townhome
2.0 star property
9.8
Exceptional
10 reviews
View
A modern hotel room with a large bed, a black leather sofa, a wooden coffee table, and a desk with a mirror.
Downtowner Inns - Houston Downtown
2.0 star property
9.2
Wonderful
282 reviews
View
A modern kitchen with a large island, bar stools, and a stainless steel refrigerator.
Wanderstay Boutique Hotel
3.0 star property
9.6
Exceptional
85 reviews
View
A large, multi-story house with a swimming pool, outdoor seating, and a red umbrella.
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
3.5 star property
9.6
Exceptional
223 reviews
View

Our guide on where to stay in South Central Houston

Find the best South Central Houston areas for the activities you enjoy most. Learn more about South Central Houston
Learn more about South Central Houston
A bridge with the words "Welcome to Downtown Houston" and a star emblem.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

A tall, modern building with a unique, vertical design, surrounded by trees and a partly cloudy sky.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

A cityscape with dense high-rise buildings, a river, and surrounding greenery.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

A city skyline with modern skyscrapers and a river flowing through a park.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

A modern cityscape with a tram and tall buildings.
Photo by George Zimzores
Open Photo by George Zimzores

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

Top South Central Houston Hotel Reviews

A multi-story hotel with a brick facade, balconies, and a well-lit entrance.
La Maison in Midtown an urban B&B

La Maison in Midtown an urban B&B

La Maison in Midtown an urban B&B
South Central Houston

10/10 Excellent

Lovely house. Location convenient for driving to places. Local streets didn't feel too safe after dark walking. Great service and breakfast and Gloria Latin Restaurant nearby. Struggled to understand the older shower/bath operation without standing in the shower with reading glasses and one or two minor maintenance issues.
Australia
John
Reviewed May 17, 2025
La Maison in Midtown an urban B&B

Frequently Asked Questions

What's it like in South Central Houston?

Travellers are sure to enjoy a stay in Houston's South Central Houston neighbourhood. Make sure that you visit TDECU Stadium and Children's Museum of Houston as part of your South Central Houston travel plans.

What's the best accommodation in South Central Houston?

Based on our traveller data, Hotel Zaza Houston Museum District is one of the top choices for your stay in South Central Houston. This hotel is a short 6-minute walk from Rice University, and it offers a full-service spa and a restaurant. Other good options for your stay in the area include Hilton Houston Plaza/Medical Center and The Westin Houston Medical Center/Museum District.

How many hotels can I expect to find in the South Central Houston area?

Expedia has 1272 hotels and other accommodation options in South Central Houston to choose from, making this an ideal home base for exploring the greater Houston area.

If I need to cancel my hotel reservation in South Central Houston, will I receive a refund?

Yes! Most room reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Add dates, click "Search", then you can filter by "fully refundable" to view the best deals available in South Central Houston.

What is there to do around this Houston neighbourhood?

Spend some time exploring the great outdoors at Hermann Park, Cullen Sculpture Garden and Twilight Epiphany Skyspace. TDECU Stadium and Children's Museum of Houston are some other stops worth a visit in the neighbourhood. Daikin Park and Toyota Center are some popular places to visit in the area around South Central Houston. Shape Community Center and Project Row Houses are also worth a visit when you're out sightseeing in Houston.

How can I get around South Central Houston and the greater Houston area?

For a quick way to explore the city, catch a ride on metro transit at Elgin/Third Ward Station, TSU/UH Athletics District Station or Ensemble/HCC Station. If you want to venture out of town, M. D. Anderson Station is the closest train station. You can also catch a ride at Kinder Station.

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