Holiday Homes in Cape Girardeau

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Check prices for these dates

Our top choices for Cape Girardeau holiday homes

1. Little Blue Cottage on Spanish

Little Blue Cottage on Spanish
Cape Girardeau
8.4 out of 10, Very good, (59 reviews)
"Great cute place. "
United States
Jeremy W.
The price is NZ$178
includes taxes & fees
6 Nov - 7 Nov
Little Blue Cottage on Spanish

2. Cozy 2-bedroom house in tranquil Cape Girardeau, close to Semo & Hospitals

Cozy 2-bedroom house in tranquil Cape Girardeau, close to Semo & Hospitals
Cape Girardeau
The price is NZ$315
includes taxes & fees
1 Dec - 2 Dec
Cozy 2-bedroom house in tranquil Cape Girardeau, close to Semo & Hospitals

3. The Little Château | Woodland Escape

The Little Château | Woodland Escape
Cape Girardeau
The price is NZ$381
includes taxes & fees
6 Nov - 7 Nov
The Little Château | Woodland Escape

4. Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly

Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly
Cape Girardeau
10.0 out of 10, Exceptional, (3 reviews)
"The house was very clean and Will kept and the whole property was well maintained. It was very comfortable and nicely decorated. The host was very responsive and helpful! Would definitely stay again and recommend."
United States
Sara C.
The price is NZ$381
includes taxes & fees
6 Nov - 7 Nov
Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly

5. The Little Cape Lofted Cottage | Creek & Nature

The Little Cape Lofted Cottage | Creek & Nature
Cape Girardeau
9.0 out of 10, Wonderful, (2 reviews)
"It was very clean and had a good feel. It was well stocked. I appreciated the cute little ice tray in the freezer that was full. I also appreciated 4 waters in the fridge. The bed on the loft upstairs was atrocious. You can feel the springs through the mattress. The downstairs bed was good. The pillows were fantastic! I’m a pillow snob. We needed a quick place to land for a church function so I can’t say much about the outside amenities as we weren’t there much. But it was a beautifully tucked...
United States
Trisha S.
The price is NZ$393
includes taxes & fees
6 Nov - 7 Nov
The Little Cape Lofted Cottage | Creek & Nature

6. 3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Cape Girardeau
8.8 out of 10, Excellent, (46 reviews)
"Will definitely book again! Great location, comfortable stay."
United States
Pynktoria !.
The price is NZ$532
includes taxes & fees
8 Nov - 9 Nov
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

7. Beautifully Renovated Farmhouse in Jackson, MO

Beautifully Renovated Farmhouse in Jackson, MO
Jackson
9.4 out of 10, Exceptional, (3 reviews)
" great stay,property landscape nicely manicured, quiet and relaxing inside and outside of the the dwelling."
United States
Sandy S.
The price is NZ$528
includes taxes & fees
10 Nov - 11 Nov
Beautifully Renovated Farmhouse in Jackson, MO

8. 4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Cape Girardeau
9.8 out of 10, Exceptional, (11 reviews)
"Nice place, great times"
United States
Jace W.
The price is NZ$974
includes taxes & fees
8 Nov - 9 Nov
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

9. Cozy and Updated Farmhouse with King Suite

Cozy and Updated Farmhouse with King Suite
Anna
10.0 out of 10, Exceptional, (29 reviews)
"Comfortable bed which is what we needed. We weren’t there long but is was everything we needed."
United States
Kathy H.
The price is NZ$286
includes taxes & fees
17 Nov - 18 Nov
Cozy and Updated Farmhouse with King Suite

10. Stunning 2 bedroom in town, close to Shawnee National Forest

Stunning 2 bedroom in town, close to Shawnee National Forest
Jonesboro
10.0 out of 10, Exceptional, (15 reviews)
"Cool renovated property that keeps that old fashioned charm. Spacious living with all the amenities you need for a vacation stay."
United States
Dylan
Stunning 2 bedroom in town, close to Shawnee National Forest

11. The Weber Farm - Enjoy a beautiful 100 acre farm!

The Weber Farm - Enjoy a beautiful 100 acre farm!
Frohna
10.0 out of 10, Exceptional, (34 reviews)
"Wonderful time! "
United States
Alison C.
The price is NZ$353
includes taxes & fees
3 Dec - 4 Dec
The Weber Farm - Enjoy a beautiful 100 acre farm!

12. Peach Tree Inn, downtown Cobden

Peach Tree Inn, downtown Cobden
Cobden
10.0 out of 10, Exceptional, (3 reviews)
"Amazing place to stay. Excellent location, beautiful rooms and accommodation and the host was so responsive. We will definitely be back!"
United States
Rebecca L.
The price is NZ$413
includes taxes & fees
15 Nov - 16 Nov
Peach Tree Inn, downtown Cobden

13. Pa’s House is an enjoyable, entirely remodeled, 2-bedroom farmhouse near Anna.

Pa’s House is an enjoyable, entirely remodeled, 2-bedroom farmhouse near Anna.
Anna
10.0 out of 10, Exceptional, (15 reviews)
"We enjoyed our stay here. The beds were very comfortable and it was close to all of the wineries along the wine trail."
United States
Kristi H.
The price is NZ$450
includes taxes & fees
17 Nov - 18 Nov
Pa’s House is an enjoyable, entirely remodeled, 2-bedroom farmhouse near Anna.

14. Beautiful location in the secluded woods

Beautiful location in the secluded woods
Pomona
9.8 out of 10, Exceptional, (86 reviews)
"This rental was very clean, pet friendly, and definitely secluded. We enjoyed our stay here."
United States
Candi M.
The price is NZ$303
includes taxes & fees
23 Nov - 24 Nov
Beautiful location in the secluded woods

15. Convenient, Cozy and Pet Friendly 2-bedroom home in Beautiful Makanda

Convenient, Cozy and Pet Friendly 2-bedroom home in Beautiful Makanda
Makanda
10.0 out of 10, Exceptional, (2 reviews)
"Easy check-in process and super convenient location to SIU, Carbondale, and the wine trail. Ample space and 2-car garage made it perfect for a group.Only room for improvement would be having central air or cooling options in the bedrooms.Overall great stay"
United States
Adam D.
Convenient, Cozy and Pet Friendly 2-bedroom home in Beautiful Makanda

16. Magical Victorian near hiking / wine trail

Magical Victorian near hiking / wine trail
Anna
10.0 out of 10, Exceptional, (21 reviews)
"Everything was beautiful, and although we weren’t there for a long time, enjoyed an Incredible sleep in the most comfortable beds!"
United States
Rachel H.
The price is NZ$631
includes taxes & fees
18 Nov - 19 Nov
Magical Victorian near hiking / wine trail

17. Walk to Weddings-Wineries-Trails, Family Friendly Home in Downtown Alto Pass

Walk to Weddings-Wineries-Trails, Family Friendly Home in Downtown Alto Pass
Alto Pass
10.0 out of 10, Exceptional, (5 reviews)
"The house was very welcoming and clean. Very inviting for our short stay. "
United States
brian O.
The price is NZ$440
includes taxes & fees
8 Nov - 9 Nov
Walk to Weddings-Wineries-Trails, Family Friendly Home in Downtown Alto Pass

18. Farm Fresh Eggs, Golf Cart, Telescope

Farm Fresh Eggs, Golf Cart, Telescope
Alto Pass
9.8 out of 10, Exceptional, (16 reviews)
"It’s a very cute old farm house nestled in a peach orchard! Rolling hills with a porch swing that overlooks the orchards and a pond. The hosts provide all of the essential's for a comfortable stay! Communication is wonderful from beginning to the end! Would stay here again and again!"
United States
Gary A.
The price is NZ$451
includes taxes & fees
30 Nov - 1 Dec
Farm Fresh Eggs, Golf Cart, Telescope

19. King Suite, Hot Tub, walk to Iron Whisk

King Suite, Hot Tub, walk to Iron Whisk
Cobden
10.0 out of 10, Exceptional, (1 review)
"Loved my stay here! The attention to details is appreciated. The shower is amazing! Loved the main area for all to gather. Walking distance to The Iron Whisk and Fuzzy’s Bar is great. I didn’t love that it’s close to train tracks and that you can’t adjust your own thermostat."
United States
Christy
The price is NZ$413
includes taxes & fees
18 Nov - 19 Nov
King Suite, Hot Tub, walk to Iron Whisk

20. King Suite, Hot Tubs, Cobden

King Suite, Hot Tubs, Cobden
Cobden
10.0 out of 10, Exceptional, (1 review)
"Everything was clean and new! We used the hot tub every night and appreciated the coffee machine! Really classy place! Access to attractions was key, and we enjoyed the neighboring restaurant (only open Thurs-Sunday) but we were less than 10 minutes from Anna for dining, and there was a great Tavern and gas station, and Dollar General less than a 1/4 block away. Highly recommended."
United States
Keith M.
The price is NZ$413
includes taxes & fees
17 Nov - 18 Nov
King Suite, Hot Tubs, Cobden
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Cape Girardeau

Explore the mighty Mississippi from the riverfront park where historic murals tell stories of river life. Climb to the top of Academic Hall at Southeast Missouri State or hunt for antiques along downtown's brick-paved streets.

A nighttime view of a bridge with its cables illuminated against a starry sky.