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Check prices for these dates

This weekend
22 May - 24 May
Next weekend
29 May - 31 May

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Our top choices for Cairo hotels

Lobby

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.4 out of 10, (285 reviews)
"Amenities, microwave, refrigerator,iron and iron board,Shower soap options "
United States
Maurice
The price is NZ$138
includes taxes & fees
12 June - 13 June
Quality Inn Cairo I-57
Basic Double Room | Living area

La Center Motel

La Center Motel
2.0 star property
La Center
7.6 out of 10, Good, (19 reviews)
"Property is located just outside of town, so very convenient yet slightly off the beaten path."
United States
Carrie
The price is NZ$108
includes taxes & fees
22 May - 23 May
La Center Motel
Lobby sitting area

The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (412 reviews)
"All very just okay "
United States
Sherry
The price is NZ$132
includes taxes & fees
22 May - 23 May
The Riverstone Hotel Charleston-Sikeston
Laptop workspace, blackout curtains, free cots/infant beds, free WiFi

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (634 reviews)
"Affordable for a quick one night stay. Restaurant and gas station next to hotel."
United States
Annette
The price is NZ$112
includes taxes & fees
7 June - 8 June
Super 8 by Wyndham Charleston/Sikeston East MO
Room, 1 King Bed, Non Smoking | View from room

Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (106 reviews)
"Great"
United States
Jackson
The price is NZ$135
includes taxes & fees
1 June - 2 June
Eagle Inn Charleston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Cairo attractions

Fort Defiance State Park

3.7/5 (15 reviews)
Where the mighty Mississippi and Ohio rivers converge, Fort Defiance Park offers a rare view of this natural phenomenon. Explore the historic grounds where Lewis and Clark once trained the Corps of Discovery in 1803.
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Learn more about Cairo

At the confluence of the Mississippi and Ohio rivers, explore Cairo's historic Fort Defiance Park with its sweeping water views. History buffs shouldn't miss the Custom House Museum, where you can discover artefacts from this once-thriving river port town.

See all hotels in Cairo
Cairo Ohio River Bridge traversing over the Ohio River at sunset

Top Cairo Hotel Reviews

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

2/10 Terrible
"DON'T STAY HERE-- KEEP GOING SOMEWHERE ELSE, & couldn't get a refund--Property is older property being renovated. The workers stay on property. The men congregate outside their rooms drinking, smoking, & some smoking weed. To each his own, but my daughter & I are allergic to cigarette smoke & get headaches really bad. Anything stronger, like weed, gets us to migraine level. It's a "pet friendly" property but NO convenient place for dogs to go out to potty. We were assigned room 116, the very last room far end of the property. No grass anywhere near. We were told to come to the front of the property in front of the office. That's a long walk at 2-3:00 AM to take the dogs out, especially w/men in & out drinking & smoking. We were uneasy w/ that. We asked for a room closer to grass for our dogs but they didn't have any available. The property still is in run down looking stage. Someone's HAIR was still in the shower and their bottle of hair conditioner. The room looked clean but bathroom floor wasn't. The beds were comfortable but weed smells coming from the corridor & outside caused migraines. We had a horrible night's sleep. On top of this terrible experience, a $100 deposit was required. I've stayed at many much nicer places & NEVER had to pay a deposit. We also had to pay per pet fee not one fee for pets per stay. It was awful, no breakfast, packs of jnstant grits and oatmeal, & coffee. We checked in about 9 & left at 5:30 AM. NEVER AGAIN"
Laurie e 1-night trip
Posted 5 days ago
Super 8 by Wyndham Charleston/Sikeston East MO

More cheap accommodation in Cairo

La Center Motel

La Center Motel

474 W Kentucky Dr La Center KY
The price is NZ$108 per night from 22 May to 23 May
NZ$108
22 May - 23 May
includes taxes & fees
7.6/10 Good! (19 reviews)

Frequently asked questions

Where is the best place for a stay in Cairo?
Based on our traveller data, Quality Inn Cairo I-57 is one of the top choices for your stay. This hotel offers free breakfast and free parking. Two other choices for your stay in the area are Super 8 by Wyndham Charleston/Sikeston East MO and The Riverstone Hotel Charleston-Sikeston. See all available top hotels, or vacation rentals in Cairo.
What are some of the best holiday rentals that Cairo has to offer?
Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286: This holiday home rental outside of Cairo is located in a rural location, and has a patio, a garden and a BBQ to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a fridge, a stovetop and a microwave, so that you can cook with friends or family. You and your friends and family can relax into your holiday with amenities such as a selection of games. See all vacation rentals in Cairo.
If I need to cancel my hotel reservation in Cairo, will I receive a refund?
Yes, the majority of room reservations are refundable if you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Cairo.
What is staying in Cairo like?
Visitors can enjoy all that Cairo has to offer, including the restaurants, entertainment choices and riverfront. This city also attracts tourists with its small-town vibe. There are 27 hotels and other accommodation options in the surrounding area. Find out more about Cairo.
What should I do while I'm visiting Cairo?
The picturesque setting of Mississippi River and Ohio River Valley exemplify the area's natural beauty. Additionally, you might want to add Fort Defiance State Park to your itinerary. Take a look at what more there is to see and do in Expedia's Cairo guide.
What's the seasonal weather like in Cairo?
The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for Cairo is 1540 mm.

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