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Our top choices for Cairo hotels

Hotel
Pet-friendly
Breakfast included
Reserve now, pay later
Motel

1. Quality Inn Cairo I-57

Quality Inn Cairo I-57
Cairo
United States
Sharon
NZ$135
includes taxes & fees
30 Aug - 31 Aug
Quality Inn Cairo I-57

2. Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
Charleston
United States
France
NZ$111
includes taxes & fees
9 Sept - 10 Sept
Super 8 by Wyndham Charleston/Sikeston East MO

3. Eagle Inn Charleston

Eagle Inn Charleston
Charleston
United States
Jackson
NZ$130
includes taxes & fees
24 Aug - 25 Aug
Eagle Inn Charleston

4. The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
Charleston
United States
Bobby
NZ$124
includes taxes & fees
10 Sept - 11 Sept
The Riverstone Hotel Charleston-Sikeston

5. La Center Motel

La Center Motel
La Center
United States
Carrie
NZ$97
includes taxes & fees
13 Sept - 14 Sept
La Center Motel

6. Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah
Cunningham
NZ$489
includes taxes & fees
29 Aug - 30 Aug
Quiet Country Stay: Modern Home Near Paducah
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Stay near popular Cairo attractions

Fort Defiance State Park

7.4/10 (15 reviews)
Where the mighty Mississippi and Ohio rivers converge, Fort Defiance Park offers a rare view of this natural phenomenon. Explore the historic grounds where Lewis and Clark once trained the Corps of Discovery in 1803.
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Learn more about Cairo

At the confluence of the Mississippi and Ohio rivers, explore Cairo's historic Fort Defiance Park with its sweeping water views. History buffs shouldn't miss the Custom House Museum, where you can discover artefacts from this once-thriving river port town.

See all hotels in Cairo
A steel bridge with a sunset in the background.

Top Cairo Hotel Reviews

Recent Reviews in Cairo

Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge

Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge

10/10 Excellent
"The location is lovely and peaceful. The cabin is clean, comfortable and relaxing. We enjoyed the pool table and ping pong."
Michelle U. 2-night trip
Posted 8 days ago
Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge
Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

10/10 Excellent
"A very clean, quiet, charming house with a fully stocked kitchen. The fresh eggs were delicious and we really enjoyed the property. Jayna was a great host and we would definitely like to return in the future."
Dave R. 3-night trip
Posted 9 days ago
Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

10/10 Excellent
"Nice staff. Very accommodating."
Domingo 1-night trip
Posted 10 days ago
Super 8 by Wyndham Charleston/Sikeston East MO
La Center Motel

La Center Motel

10/10 Excellent
"Great AC unit in the room!"
Jonathan 1-night trip
Posted 11 days ago
La Center Motel
Beautiful newly renovated farm house overlooking 5 acre lake. ****New Rates ***

Beautiful newly renovated farm house overlooking 5 acre lake. ****New Rates ***

10/10 Excellent
"When I arrived the beauty of the house and property far exceeded my expectations. Walking into home you can feel 100 years of history, but you quickly realize that the Host has been so attentive to every detail imaginable to make your stay incredible. When you’re in the kitchen sitting around the island enjoying time with friends and family take a moment to look at a book that is there on the shelf telling the history of Union county Illinois. This wonderful home is located in Union County Illinois and to my pleasant surprise, I found a picture of my Great Great Grandfather in this book. He was born in 1876. This is 5 Star accommodations and I encourage you to treat yourself to such luxury."
Anonymous traveller 2-night trip
Posted 12 days ago
Beautiful newly renovated farm house overlooking 5 acre lake. ****New Rates ***
Charming Home just minutes from Interstate and Mall

Charming Home just minutes from Interstate and Mall

10/10 Excellent
"This place is a cozy, charming, clean, close to everything we wanted to see in Paducah place to stay. The neighborhood is quiet and peaceful. The host is very responsive and helpful. I wish we could have stayed longer. We would stay here again."
Vinette M. 2-night trip
Posted 2 months ago
Charming Home just minutes from Interstate and Mall
Charming cottage overlooking Lake Acre

Charming cottage overlooking Lake Acre

10/10 Excellent
"This was our second time staying here and we stayed for a full week. Fully enjoyed the time away from home. I did a lot of fishing and my wife did some crafting. Enjoyed a fire down by the lake with roasted hotdogs and s'mores. Grilled for dinner a couple of times also. Other nights we brought pre-prepared meals. It's a great getaway out away from the cities. Be prepared to relaxed and enjoy!"
Paul B. 6-night trip
Posted 2 months ago
Charming cottage overlooking Lake Acre
Welcoming 4-bedroom house with AC in charming La Center

Welcoming 4-bedroom house with AC in charming La Center

10/10 Excellent
"We needed a 1 night stay, got in late. Great house and it was clean. The only comment I would say and they are very minor is, there was no light outside and it was very dark. Also, the rug at the front door both inside and out, had no grip so we slid around a bit."
vickie b. 1-night trip
Posted 3 months ago
Welcoming 4-bedroom house with AC in charming La Center
Cozy cabins on beautiful Horseshoe Lake

Cozy cabins on beautiful Horseshoe Lake

10/10 Excellent
"Beautiful Property"
Mark 2-night trip
Posted 3 months ago
Cozy cabins on beautiful Horseshoe Lake

More cheap accommodation in Cairo

La Center Motel

La Center Motel

474 W Kentucky Dr La Center KY
NZ$97
13 Sept - 14 Sept
includes taxes & fees
7.6/10 Good! (22 reviews)
La Center Motel
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

310 S Story St Charleston MO
NZ$111
9 Sept - 10 Sept
includes taxes & fees
Super 8 by Wyndham Charleston/Sikeston East MO
The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston

102 Drake St Charleston MO
NZ$124
10 Sept - 11 Sept
includes taxes & fees
The Riverstone Hotel Charleston-Sikeston
Eagle Inn Charleston

Eagle Inn Charleston

2811 East Marshall Street Charleston MO
NZ$130
24 Aug - 25 Aug
includes taxes & fees
6.6/10 (106 reviews)
Eagle Inn Charleston
Quality Inn Cairo I-57

Quality Inn Cairo I-57

13201 Kessler Road Cairo IL
NZ$135
30 Aug - 31 Aug
includes taxes & fees
6.4/10 (293 reviews)
Quality Inn Cairo I-57

Find out more about Cairo

Top reasons to visit Cairo

  • Outdoor Adventures: Cairo, Illinois, offers a wealth of outdoor activities, including hiking, camping, and riverboat tours, perfect for nature enthusiasts.
  • Scenic Beauty: Enjoy picturesque landscapes and stunning views that make Cairo an inviting escape for relaxation and exploration.
  • Rich History: Explore the charming streets and historic sites, immersing yourself in the local culture and heritage.
  • Family-Friendly Activities: Engage in various recreational activities suitable for the whole family at local campgrounds.
  • Diverse Accommodations: Choose from a range of welcoming lodgings, including pet-friendly and LGBTQIA-friendly options.

Find great hotels in and around Cairo

Discover a range of welcoming accommodations in Cairo, Illinois, perfect for every traveller. From charming agritourism properties to convenient motels, you'll find pet-friendly options and family-oriented services. Whether you're seeking an LGBTQIA-friendly stay or simply a comfortable place to rest, Cairo's hotels and inns cater to diverse needs, ensuring a memorable visit to this unique destination.

  • Super 8 by Wyndham Charleston/Sikeston East MO: Located a mere 16.1km from Cairo, the Super 8 by Wyndham Charleston/Sikeston East MO offers a budget-friendly motel experience that caters to families and pet owners alike. This establishment prides itself on being family-oriented, providing essential amenities such as free cribs and specific arrangements for younger guests. Additionally, it welcomes pets, ensuring your furry companions can join in on your travels. With a focus on comfort and convenience, this motel is an excellent choice for those seeking a relaxed stay without breaking the bank.
  • The Riverstone Hotel Charleston-Sikeston: Situated 19.3km from Cairo, The Riverstone Hotel Charleston-Sikeston combines budget-friendly pricing with a professional atmosphere ideal for business travellers. This hotel embraces a pet-friendly policy, making it accommodating for those travelling with pets, while also providing a suitable environment for work-related stays. Guests can enjoy essential amenities tailored for comfort and productivity, making it a solid choice for both leisure and business visits in the region.
  • Quality Inn Cairo I-57: Nestled in the heart of Cairo, the Quality Inn Cairo I-57 is a budget-friendly hotel that welcomes families and pet lovers. The property is equipped with thoughtful amenities for children such as free cribs and a first aid kit, ensuring a safe and comfortable environment for all guests. With a pet policy that permits dogs and accommodates service animals, this hotel is an excellent option for those looking for a blend of comfort and convenience in their stay.

Where to stay near Cairo

For an unforgettable vacation experience, Cairo, Illinois offers a delightful mix of outdoor adventures and rich history. Stroll through the charming streets of Cairo, exploring its unique neighbourhoods, or enjoy family-friendly activities at local campgrounds. Just a stone’s throw away, discover the vibrant atmosphere of nearby cities, perfect for both relaxation and exploration. Whether you're soaking in the local culture or adventuring in nature, Cairo promises a memorable getaway.

  • Wickliffe: Located a mere 9.7km from Cairo, Wickliffe is a charming city that beckons travellers with its stunning outdoor scenery and romantic experiences. With visitor numbers peaking from March to April and August, this inviting locale offers a variety of recreational activities. Golf enthusiasts can enjoy local courses, while nature lovers can explore nearby lakes and the national state park. The serene forests surrounding Wickliffe provide the perfect backdrop for hiking and picnicking, making it an ideal spot for those seeking relaxation amidst nature.
  • Mound City: Also situated 9.7km from Cairo, Mound City is another appealing destination for outdoor adventurers and couples looking for a romantic getaway. With peak visitor seasons in March, July, and October, this city offers a plethora of activities including access to recreational parks and golf courses. Nature enthusiasts will appreciate the nearby forests, lakes, and urban parks, all waiting to be explored. Mound City’s blend of adventure and scenic beauty ensures a memorable experience for all who visit.
  • Wyatt: Just 11.3km from Cairo, Wyatt is a family-friendly city that offers a delightful mix of outdoor activities and urban charm. With peak travel periods from June to August, families can enjoy the local golf courses, dog parks, and urban parks that create a vibrant community atmosphere. Wyatt's event and conference venues make it an ideal spot for gatherings, while the accessible parks provide a great space for relaxation and fun. This city promises a well-rounded experience for visitors of all ages.

Things to do in Cairo

Shopping

Cairo offers a quaint shopping experience with local boutiques and souvenir shops. For a wider selection, if you're up for a drive, head to the nearby Town Square in Paducah or the Mall at 270 in Cape Girardeau, both offering a variety of retail options.

Recreation

In Cairo, the Riverfront Park offers a tranquil setting along the Mississippi River, ideal for leisurely strolls and picnics. For relaxation, visit a local spa that provides rejuvenating treatments and massages, ensuring a refreshing experience amid the charming surroundings.

Adventure

Cairo offers a unique blend of history and adventure. Explore the scenic Mississippi River by kayaking or fishing. Visit the nearby Trail of Tears State Park for hiking amidst stunning landscapes, or enjoy birdwatching at the confluence of the Ohio and Mississippi rivers, where nature thrives.

Nightlife

Explore the atmosphere at The Hangout, where you can enjoy live music and a vibrant crowd. For a relaxed evening, visit The Cairo Café, serving up tasty bites and a selection of local brews. Don't miss the chance to mingle with friendly locals and discover the area's charm.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Find the best attractions in and around Cairo

Cairo, Illinois, is an ideal destination for those seeking outdoor adventures and stunning scenery. Visitors can explore a variety of attractions, including national parks, nature reserves, and historic forts. Whether you're after cultural experiences or simply want to soak up the beautiful landscapes, Cairo offers plenty of opportunities to enjoy the great outdoors and discover its rich history.

  • Columbus-Belmont State Park: Located 27.4km from Cairo, this national park offers stunning outdoor scenery and adventure opportunities. Visitors can enjoy hiking trails, picnic areas, and breathtaking views of the Mississippi River, making it a great spot for nature lovers.
  • Ballard Wildlife Management Area: Just 8.0km away from Cairo, this wildlife preserve is rich in history and is an affordable option for those keen on birdwatching and exploring natural habitats. The area is ideal for quiet reflection and observing wildlife in their natural setting.
  • Fort Defiance State Park: Situated within Cairo, this historic fort showcases local culture and history. The park features walking trails and informative displays, providing insight into the region’s past while offering lovely views of the confluence of the Mississippi and Ohio Rivers.

Best time to go to Cairo

The best time to visit Cairo can depend on the weather and when visitor numbers rise and fall. The hottest average temperature in Cairo falls in July, when visitor numbers are average and weather is mostly sunny with light rain. The coolest average temperature in Cairo falls in January, visitor numbers are moderately low and weather is mostly sunny with light rain.

calendar iconCalendar Monthtemperature iconTemperaturerain iconPrecipitationmostly cloudy iconCloudinessoccupation rate iconOccupancyprice iconPricing
January35.2°F (1.8°C)Light RainMostly SunnyModerately LowSlightly Low
February38.5°F (3.6°C)Light RainMostly SunnyModerately LowAverage
March48.7°F (9.3°C)Light RainMostly SunnyModerately HighSlightly High
April57.7°F (14.3°C)Light RainMostly SunnyModerately HighSlightly High
May67.5°F (19.7°C)Light RainMostly SunnyAverageSlightly High
June76.5°F (24.7°C)Light RainMostly SunnyAverageAverage
July79.0°F (26.1°C)Light RainMostly SunnyAverageAverage
August77.2°F (25.1°C)Light RainMostly SunnyModerately HighAverage
September71.6°F (22.0°C)Light RainMostly SunnyAverageAverage
October60.1°F (15.6°C)Light RainMostly SunnyAverageAverage
November47.8°F (8.8°C)Light RainMostly SunnyModerately LowSlightly Low
December40.6°F (4.8°C)Light RainMostly SunnyAverageSlightly Low

The nearest major airports for your trip to Cairo

Flying into Cairo, Illinois, is convenient with several nearby airports. Paducah, KY (PAH-Barkley Regional) is 37.0km away, where you can find quality accommodation such as The Respite Bed and Breakfast, 14.5km from the airport, and Harrah's Metropolis Hotel & Casino, 9.7km away. Cape Girardeau, MO (CGI-Cape Girardeau Municipal) is 41.8km from Cairo, with options like Drury Plaza Hotel, 9.7km from the airport. Additionally, Veterans Airport of Southern Illinois (MWA) is 83.7km away, featuring hotels like Drury Inn & Suites Marion, just 3.2km from the airport. Each location offers various transport services to facilitate your travel to Cairo.

Frequently asked questions

What is the best area to stay in Cairo?
The best area to stay in Cairo, Illinois, is near the downtown historic district, particularly around Commercial Avenue.This area, though small, represents the heart of Cairo's history and offers the most convenient access to its remaining landmarks. Commercial Avenue was once the main commercial thoroughfare, and while many buildings are now vacant, it provides a glimpse into the town's past. Travellers will find the most accessible options for overnight stays here.For history enthusiasts, staying in this central area is ideal. You're within walking distance of historic buildings and the confluence of the Ohio and Mississippi Rivers, a significant geographical point.
What are the best hotels in Cairo that travellers recommend?
For a recommended hotel in Cairo, Illinois, consider the Quality Inn Cairo I-57.The Quality Inn Cairo I-57 offers a comfortable stay with amenities such as air conditioning, free breakfast including a full breakfast, and a kitchen in the rooms. Guests appreciate the nice, clean rooms and the quite good breakfast. The staff also receives positive comments for being nice. For convenience, the hotel provides free self-parking, accessible van parking, and parking for RVs, buses, and trucks.
What are the best family hotels in Cairo?
For a family-friendly hotel in Cairo, the Quality Inn Cairo I-57 is a highly suitable option.This hotel offers a range of complimentary amenities that are ideal for families. Guests can enjoy free WiFi, free toiletries, and free self-parking. Furthermore, the hotel provides a complimentary full breakfast, and cribs are available for free, which is very convenient for those travelling with young children. Guests have consistently praised the nice, clean rooms, the quite good breakfast, and the nice staff, all contributing to a pleasant stay.
What hotels in Cairo offer free breakfast?
For hotels in Cairo that offer complimentary breakfast, the Quality Inn Cairo I-57 is a superb option.The Quality Inn Cairo I-57 provides guests with a free full breakfast, ensuring a great start to the day. This hotel also offers free WiFi and complimentary self-parking, adding to the convenience. Guests have frequently commented on the nice, clean rooms and the quite good breakfast. The staff are also regularly mentioned for being nice. This hotel is located within easy reach of the Mississippi River and the Ohio River.
What are the top pet-friendly hotels in Cairo?
For pet-friendly accommodation in Cairo, the Quality Inn Cairo I-57 is a highly recommended option.The Quality Inn Cairo I-57 permits pets, with a cleaning amount applicable for their stay. It also offers a complimentary full breakfast, which many guests describe as quite good. Reviewers often mention the nice and clean rooms, and the staff are frequently praised for being friendly. This hotel is also conveniently located near the Mississippi River and the Ohio River.
What are the best budget hotels in Cairo?
For a much-loved budget hotel in Cairo, the Quality Inn Cairo I-57 is an excellent option.This hotel offers convenient amenities such as complimentary WiFi, free toiletries, and free self-parking. Guests particularly appreciate the complimentary full breakfast provided. Reviews frequently mention the nice, clean rooms, the quite good breakfast, and the nice staff.
What are the best hotels in Cairo near Mississippi River?
For a hotel near the Mississippi River in Cairo, consider the Quality Inn Cairo I-57.This hotel offers convenient amenities for families, including free cots and complimentary full breakfast. Guests frequently praise the nice, clean rooms and the quite good breakfast. The staff also receive positive comments for their helpfulness. You will also benefit from free WiFi, complimentary toiletries, and free self-parking.
When is the best time to go to Cairo?
The best time to visit Cairo, Illinois is during the late spring (April to May) and early autumn (September to October) months.These periods offer the most pleasant weather for exploring the area. During late spring, temperatures are mild, typically ranging from 15°C to 25°C, and the natural scenery along the rivers is lush. Early autumn brings similar comfortable temperatures, often between 18°C and 28°C, with the added beauty of changing leaves.For couples looking for a relaxed getaway, these shoulder seasons are ideal. The weather is great for walking along the riverfront, visiting historic sites like the Custom House Museum, or enjoying the quiet charm of the town without the extreme heat of summer. It's a great time for photography as well, capturing the blend of history and nature.Solo travellers will also appreciate the comfortable conditions for exploring the area's historical significance, particularly its role in the Civil War.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, although it depends on the cancellation policy of your booking. Most bookings are refundable if cancelled within 24 to 48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to 'My Trips' and selecting your reservation. To find flexible deals, filter your search by 'Fully refundable property' for hotels in Cairo.
How can I save on a hotel booking in Cairo with Expedia?
One Key™—Expedia's free travel rewards program—gives you instant access to discounts with Member Prices on Cairo hotels. Plus, you'll earn OneKeyCash™* on eligible bookings to use on future trips. Booking an Expedia hotel and flight package is another great way to save, where bundling can result in significant savings. *Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
How much is the nightly rate for a hotel in Cairo?
Prices for hotels in Cairo often vary, but you can find a great deal from NZ$97 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by 'Price: low to high' for our cheapest rates.

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