Access is by heading northeast from Bariloche along National Route 237. The route crosses the Ñireco Stream and the Ñirihuau River. Then, after reaching the headwaters of the Limay River in Lake Nahuel Huapi (the border between the provinces of Río Negro and Neuquén), the route will take you along the banks of this river until you reach its confluence with the Trafúl River. Stops can be made at the Limay River Amphitheatre, Villa Llanquín, and Valle Encantado, where you can see strange figures outlined by the rock formations.

A few miles further on, you'll reach Confluencia and, from there, take Provincial Route 65, which is a gravel road. The route follows the Trafúl River Valley, crossing some of its tributaries (the Cuyin Manzano River and the Minero River) until reaching Lake Trafúl, on the shores of which lies the town of Villa Trafúl. At this destination, you can visit the main pier, stroll through its streets, and/or stop at a pastry shop.

Continuing westward along the shore of Lake Trafúl, you'll reach Puerto Arrayán, the Catarata Stream waterfall, and finally Paso Portezuelo, the gateway to the Seven Lakes Route (RN 40). The route continues south. After visiting lakes Correntoso and Espejo, you'll reach Villa La Angostura. There, you can stroll through the shopping area and stop for lunch. The return journey is via the isthmus of the Quetrihué Peninsula, taking in its unparalleled views and heading back to Bariloche along Route 40.