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Top Spa Florida Keys Hotels

Cheeca Lodge & Spa

81801 Overseas Highway, Mile Marker 82 Islamorada FL

3 hours drive from Florida Keys Beaches

Stay at this luxury resort in Islamorada. Enjoy free parking, 3 outdoor pools and a full-service spa. Our guests praise the pool and the helpful staff in their ...

9.2/10 Wonderful! (1,346 reviews)

"Best place in Islamorada by far."

Reviewed on 22 July 2026

Pier House Resort & Spa

1 Duval St Key West FL

37 min drive from Florida Keys Beaches

Stay at this beach resort in Key West. Enjoy a full-service spa, a private beach and 2 bars/lounges. Our guests praise the pool and the helpful staff in their ...

9/10 Wonderful! (1,242 reviews)

"I was informed that to get a late checkout time (2:00 pm) that it would cost an extra $100.. which was fine with me Upon checking out, I received the itemized expenses of my stay and I was in fact actually charged $200 for my late checkout… unacceptable."

Reviewed on 23 July 2026

Southernmost Beach Resort and Guesthouses

1319 Duval Street Key West FL

36 min drive from Florida Keys Beaches

Stay at this beach hotel in Key West. Enjoy free Wi-Fi, 3 outdoor pools and a full-service spa. Our guests praise the pool and the helpful staff in their reviews. ...

See all 8,270 properties in Florida Keys

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.