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Top Spa Florida Keys Hotels

Cheeca Lodge & Spa

81801 Overseas Highway, Mile Marker 82 Islamorada FL

3 hours drive from Duval Street

Stay at this luxury resort in Islamorada. Enjoy free parking, 3 outdoor pools and a full-service spa. Our guests praise the pool and the helpful staff in their ...

9.2/10 Wonderful! (1,315 reviews)

Booked premium beachfront king suite 40 days in advance. Confirmed the day before and when we got there we were given a double queen bed suite. Disappointed

Reviewed on 16 Apr 2026

Pier House Resort & Spa

1 Duval St Key West FL

11 min walk from Duval Street

Stay at this beach resort in Key West. Enjoy a full-service spa, a private beach and 2 bars/lounges. Our guests praise the pool and the helpful staff in their ...

9/10 Wonderful! (1,083 reviews)

We loved the location and the rooms. But my favorite was the beds!! OMG i slept so great on these beds. When i got home i called them to find out the manufacturer and model because I'm going to order the same bed for my house lol. Great time highly recommend Key west and the Pier House Resort

Reviewed on 17 Apr 2026

Southernmost Beach Resort and Guesthouses

1319 Duval Street Key West FL

10 min walk from Duval Street

Stay at this beach hotel in Key West. Enjoy free Wi-Fi, 3 outdoor pools and a full-service spa. Our guests praise the pool and the helpful staff in their reviews. ...

8.8/10 Excellent! (3,212 reviews)

Great place to go. close to everything and they offer many options have several pools, ,beautiful beach. Offer trivia games and other things for entertainment fun. So glad I stayed here and highly recommend.

Reviewed on 17 Apr 2026

See all 8,278 properties in Florida Keys

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.