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Top Romantic Southern Minnesota Hotels

Alexander Mansion Bed and Breakfast

274 East Broadway Winona MN

2 hours drive from Mayo Clinic

Stay at this B&B in Winona. Enjoy free parking, a business centre and daily housekeeping. Popular attractions Winona Arts Center and Watkins Heritage Museum ...

9.8/10 Exceptional! (514 reviews)

"Richard was a wonderful host. The mansion was clean and the front porch was wonderful! (A little noisy as it is on a busy street). Breakfast was amazing!! Be prepared to spend some time at breakfast. Overall a great stay, and would stay again!"

Reviewed on 16 June 2026

St James Hotel, a Historic Hotel of America

406 Main St. Red Wing MN

2 hours drive from Mayo Clinic

Stay at this spa hotel in Red Wing. Enjoy free Wi-Fi, free parking and a full-service spa. Our guests praise the helpful staff and the comfy rooms in their reviews. ...

9.2/10 Wonderful! (1,011 reviews)

"Loved it"

Reviewed on 15 June 2026

AmericInn by Wyndham Austin

1700 8th St NW Austin MN

2 hours drive from Mayo Clinic

Stay at this business-friendly hotel in Austin. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean rooms in ...

8.8/10 Excellent! (752 reviews)

"Everything was clean. Beds were a little soft for our liking, but still comfortable. Bathroom in 2 queen room was TINY."

Reviewed on 13 June 2026

See all 1,183 properties in Southern Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.