Photo by Serendipity Trip

Plan, book, travel with confidence
Better together
Save up to NZ$2,400 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Luxury Southeastern Indiana Hotels

21c Museum Hotel Louisville

700 W Main Street Louisville KY

3 min walk from Louisville Slugger Museum

Stay at this luxury hotel in Louisville. Enjoy free Wi-Fi, a full-service spa and breakfast (surcharge). Our guests praise the restaurant and the helpful staff ...

9.4/10 Exceptional! (1,005 reviews)

"21c is a great location for those visiting downtown Louisville. The staff was attentive and very friendly. Love the art and fun features throughout the hotel, restaurant and bar. We will be back."

Reviewed on 21 June 2026

West Baden Springs Hotel

8538 W Baden Ave West Baden Springs IN

2 hours drive from Louisville Slugger Museum

Stay at this luxury resort in West Baden Springs. Enjoy free Wi-Fi, a full-service spa and 15 restaurants. Popular attractions French Lick Winery and FLWB Indoor ...

The Brown Hotel

335 W Broadway Louisville KY

16 min walk from Louisville Slugger Museum

Stay at this luxury hotel in Louisville. Enjoy free Wi-Fi, breakfast (surcharge) and a free airport shuttle. Our guests praise the helpful staff and the clean ...

See all 1,136 properties in Southeastern Indiana

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.