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Top Luxury Southwest Houston Hotels

Hotel Granduca Houston

1080 Uptown Park Blvd Houston TX

9 min drive from MD Anderson Cancer Center

Stay at this luxury hotel in Houston. Enjoy free Wi-Fi, 2 bars/lounges and breakfast (surcharge). Our guests praise the helpful staff in their reviews. Popular ...

9.2/10 Wonderful! (1,001 reviews)

"My wife and I had an incredible weekend!"

Reviewed on 8 Nov 2026

Houston Grand Hotel - River Oaks

1919 Briar Oaks Ln Houston TX

7 min drive from MD Anderson Cancer Center

Stay at this luxury hotel in Houston. Enjoy breakfast (surcharge), 24-hour room service and a 24-hour fitness centre. Popular attractions Reliant Stadium and ...

9.2/10 Wonderful! (527 reviews)

"Hotel was very clean and elegant"

Reviewed on 12 Nov 2026

JW Marriott Houston by the Galleria

5150 Westheimer Rd Houston TX

6 min drive from MD Anderson Cancer Center

Stay at this luxury hotel in Houston. Enjoy 2 restaurants, breakfast (surcharge) and 24-hour room service. Popular attractions Reliant Stadium and Westheimer ...

8.8/10 Excellent! (1,001 reviews)

"Dated, Overpriced, and Disappointing — 3 Stars at Best As a frequent traveler who stays in hotels regularly, I found this property extremely disappointing. The hotel is dated, worn, and desperately needs a refresh. The check-in process was painfully slow, the breakfast was unappetizing, and the bed ..."

Reviewed on 11 Nov 2026

See all 1,297 properties in Southwest Houston

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.