Photo by Kirsten

Plan, book, travel with confidence
Better together
Save up to NZ$2,400 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Luxury Southern Minnesota Hotels

Kahler Grand Hotel

20 2nd Ave Sw Rochester MN

2 min walk from Mayo Clinic

Stay at this business-friendly hotel in Rochester. Enjoy free Wi-Fi, 2 restaurants and breakfast (surcharge). Our guests praise the helpful staff and the clean ...

8.4/10 Very Good! (2,026 reviews)

Was put in a room that is used for Expedia customers. Only 2 smaller windows, one foged up. Not a good mattress. 2 outside doors, on both side of our room. Slammed night and day. Rattled our room. Plan on better room next time.

Reviewed on 27 Apr 2026

AmericInn by Wyndham Blue Earth

1495 Domes Dr Blue Earth MN

5 hours drive from Mayo Clinic

Stay at this business-friendly hotel in Blue Earth. Enjoy free breakfast, free Wi-Fi and free parking. Popular attractions Jolly Green Giant Museum and Jolly ...

7.8/10 Good! (471 reviews)

Breakfast was great! Coffee didn't taste fresh, but we got there at 9ish, so maybe just old. But sometimes it can be dirty pots. Other than that, it was a fine place to stay for the night. I did wake up a little congested, after having left the fan on all night. Upon inspecting it, the filter was ...

Reviewed on 21 Apr 2026

Med City Inn & Suites - Mayo Clinic Area

435 16th Ave Nw Rochester MN

26 min walk from Mayo Clinic

Stay at this family-friendly motel in Rochester. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in ...

7.8/10 Good! (1,004 reviews)

Pool is wonderful with play stuff for kids and a great hot tub. The breakfast area is the cleanest ever! There is no meat for breakfast but otherwise anything you'd need. Great job there! The property is attached to Famous Dave's BBQ and it is GREAT! The property is old but clean. If you had to, ...

Reviewed on 27 Apr 2026

See all 1,207 properties in Southern Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.