Southern Minnesota Luxury Holidays 2026

Photo by Kirsten

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Top Luxury Southern Minnesota Hotels

Kahler Grand Hotel

20 2nd Ave Sw Rochester MN

2 min walk from Mayo Clinic

Stay at this business-friendly hotel in Rochester. Enjoy free Wi-Fi, 2 restaurants and breakfast (surcharge). Our guests praise the helpful staff and the clean ...

8.4/10 Very good! (2,324 reviews)

"Old feel. Still going through renovations and more needs to be done to meet current market standards"

Reviewed on 24 Sept 2026

AmericInn by Wyndham Blue Earth

1495 Domes Dr Blue Earth MN

5 hours drive from Mayo Clinic

Stay at this business-friendly hotel in Blue Earth. Enjoy free breakfast, free Wi-Fi and free parking. Popular attractions Jolly Green Giant Museum and Jolly ...

7.8/10 Good! (516 reviews)

"Our room smelled musty. There was no elevator. We both got some kind of bug bites. It was not clean"

Reviewed on 21 Sept 2026

Med City Inn & Suites - Mayo Clinic Area

435 16th Ave Nw Rochester MN

26 min walk from Mayo Clinic

Stay at this family-friendly motel in Rochester. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in ...

7.8/10 Good! (1,018 reviews)

"Rooms were clean and the room temperature was comfortable. We did not spendmuch time there, as we were at Mayo Clinics most of the time."

Reviewed on 24 Sept 2026

See all 1,233 properties in Southern Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.