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Top Luxury Southern Minnesota Hotels

Kahler Grand Hotel

20 2nd Ave Sw Rochester MN

2 min walk from Mayo Clinic

Stay at this business-friendly hotel in Rochester. Enjoy free Wi-Fi, 2 restaurants and breakfast (surcharge). Our guests praise the helpful staff and the clean ...

8.2/10 Very Good! (1,857 reviews)

The amenities and the great customer service.

Reviewed on 18 Jan 2026

AmericInn by Wyndham Blue Earth

1495 Domes Dr Blue Earth MN

5 hours drive from Mayo Clinic

Stay at this business-friendly hotel in Blue Earth. Enjoy free breakfast, free Wi-Fi and free parking. Popular attractions Jolly Green Giant Statue and Wakefield ...

7.8/10 Good! (462 reviews)

Courteous service. Room not spotless but not bad.

Reviewed on 8 Jan 2026

Med City Inn & Suites - Mayo Clinic Area

435 16th Ave Nw Rochester MN

26 min walk from Mayo Clinic

Stay at this family-friendly motel in Rochester. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in ...

7.8/10 Good! (1,001 reviews)

Ok

Reviewed on 12 Jan 2026

See all 1,197 properties in Southern Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.