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Top Luxury Northeast Ohio Hotels

InterContinental Cleveland by IHG

9801 Carnegie Ave Cleveland OH

4 min walk from Cleveland Clinic

Stay at this luxury hotel in Cleveland. Enjoy free Wi-Fi, 2 restaurants and breakfast (surcharge). Our guests praise the helpful staff in their reviews. Popular ...

9/10 Wonderful! (862 reviews)

Nice room, restaurants on site and convenient to Cleveland Clinic! Highly recommended!

Reviewed on 20 Jan 2026

The Ritz-Carlton, Cleveland

1515 West Third Street Cleveland OH

10 min drive from Cleveland Clinic

Stay at this luxury hotel in Cleveland. Enjoy breakfast (surcharge), 24-hour room service and a 24-hour fitness centre. Popular attractions JACK Cleveland Casino ...

8.8/10 Excellent! (277 reviews)

Clean, spacious rooms. Very helpful staff

Reviewed on 17 Jan 2026

Drury Plaza Hotel Cleveland Downtown

1380 East 6th Street Cleveland OH

9 min drive from Cleveland Clinic

Stay at this hotel in Cleveland. Enjoy free breakfast, free Wi-Fi and a fitness centre. Our guests praise the breakfast and the helpful staff in their reviews. ...

9.4/10 Exceptional! (2,650 reviews)

Great staff

Reviewed on 21 Jan 2026

See all 4,253 properties in Northeast Ohio

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.