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Top Luxury Northeast Missouri Hotels

The Royal Sonesta Chase Park Plaza St. Louis

212 N Kingshighway St. Louis MO

6 min drive from St. Louis Union Station

Stay at this luxury hotel in St. Louis. Enjoy free Wi-Fi, an outdoor pool and 3 restaurants. Our guests praise the helpful staff and the clean rooms in their ...

9/10 Wonderful! (1,011 reviews)

"Loved our stay! We had a girls’ weekend and the pool was definitely the highlight of our stay with the good drinks and food!"

Reviewed on 29 June 2026

Ameristar Casino Resort and Spa

1 Ameristar Blvd St. Charles MO

34 min drive from St. Louis Union Station

Stay at this luxury hotel in St. Charles. Enjoy a full-service spa, 6 restaurants and a casino. Our guests praise the clean rooms in their reviews. Popular attractions ...

8.6/10 Excellent! (1,008 reviews)

"This is a tough one for me to rate because I liked lots about the property and disliked a lot. The good: * huge, comfortable rooms * great location * free parking * friendly staff The bad: * the housekeeping is slow, non-responsive (example: they didn't take out our garbage for days, even when requested) ..."

Reviewed on 30 June 2026

The Ritz-Carlton, St. Louis

100 Carondelet Plaza St. Louis MO

13 min drive from St. Louis Union Station

Stay at this luxury hotel in St. Louis. Enjoy 2 restaurants, 3 bars/lounges and breakfast (surcharge). Our guests praise the helpful staff and the room service ...

9.2/10 Wonderful! (573 reviews)

"Very nice property to stay at and a nice walk to Shaw Park."

Reviewed on 28 June 2026

See all 2,960 properties in Northeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.