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Top Luxury Northeast Missouri Hotels

The Royal Sonesta Chase Park Plaza St. Louis

212 N Kingshighway St. Louis MO

6 min drive from St. Louis Union Station

Stay at this luxury hotel in St. Louis. Enjoy free Wi-Fi, an outdoor pool and 3 restaurants. Our guests praise the helpful staff and the clean rooms in their ...

9/10 Wonderful! (1,000 reviews)

The room was amazing and the staff made our stay perfect! There is so much to do at the hotel from the movie theatre to dining and drinks you really don’t have to leave.

Reviewed on 23 Jan 2026

Ameristar Casino Resort and Spa

1 Ameristar Blvd St. Charles MO

34 min drive from St. Louis Union Station

Stay at this luxury hotel in St. Charles. Enjoy an outdoor pool, a full-service spa and 6 restaurants. Our guests praise the clean rooms in their reviews. Popular ...

8.4/10 Very Good! (1,000 reviews)

The room was great. I enjoyed my stay.

Reviewed on 3 Feb 2026

The Ritz-Carlton, St. Louis

100 Carondelet Plaza St. Louis MO

13 min drive from St. Louis Union Station

Stay at this luxury hotel in St. Louis. Enjoy 2 restaurants, 3 bars/lounges and breakfast (surcharge). Our guests praise the helpful staff and the room service ...

9.2/10 Wonderful! (556 reviews)

Very courteo

Reviewed on 13 Jan 2026

See all 2,839 properties in Northeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.