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Top Luxury Southeast Missouri Hotels

Super 8 by Wyndham Pevely

1711 Highway Z Pevely MO

3 hours drive from Mark Twain National Forest

Stay at this business-friendly motel in Pevely. Enjoy free breakfast, free Wi-Fi and free parking. Popular attractions Pevely Park and Sun Valley Park are located ...

5.6/10 (831 reviews)

Awesome

Reviewed on 11 Nov 2025

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

3 hours drive from Mark Twain National Forest

Stay at this motel in Poplar Bluff. Enjoy free Wi-Fi, free parking and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in their ...

7.8/10 Good! (1,004 reviews)

Love the updated rooms and the vending area.

Reviewed on 6 Dec 2025

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

4 hours drive from Mark Twain National Forest

Stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean rooms ...

7.2/10 Good! (1,001 reviews)

Very nice room, staff was nice. The tv room and bathroom were cold. No heat in those rooms.

Reviewed on 7 Dec 2025

See all 620 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.