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Top Luxury Eastern Piedmont Hotels

The Umstead Hotel and Spa

100 Woodland Pond Dr Cary NC

29 min drive from Duke University

Stay at this luxury resort in Cary. Enjoy free Wi-Fi, free parking and an outdoor pool. Our guests praise the helpful staff in their reviews. Popular attractions ...

9.6/10 Exceptional! (759 reviews)

Everything is incredible. Highly recommend getting a massage!

Reviewed on 27 Apr 2026

The Carolina Inn, a Destination by Hyatt Hotel

211 Pittsboro Street Chapel Hill NC

16 min drive from Duke University

Stay at this luxury hotel in Chapel Hill. Enjoy free Wi-Fi, breakfast (surcharge) and a free local area shuttle. Our guests praise the helpful staff in their ...

9.6/10 Exceptional! (1,001 reviews)

The Hotel and the staff were lovely, unfortunately we did not have a car, so we needed cabs for shops and restaurants.

Reviewed on 27 Apr 2026

The Mayton

301 S Academy St Cary NC

37 min drive from Duke University

Stay at this boutique hotel in Cary. Enjoy free Wi-Fi, free parking and breakfast (surcharge). Our guests praise the helpful staff in their reviews. Popular ...

9.4/10 Exceptional! (749 reviews)

State’s breakfast credit on site. There was no breakfast credit or discount,

Reviewed on 27 Apr 2026

See all 4,954 properties in Eastern Piedmont

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.