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Top Luxury Eastern Piedmont Hotels

The Umstead Hotel and Spa

100 Woodland Pond Dr Cary NC

29 min drive from Duke University

Stay at this luxury resort in Cary. Enjoy free Wi-Fi, free parking and an outdoor pool. Our guests praise the helpful staff in their reviews. Popular attractions ...

9.4/10 Exceptional! (709 reviews)

Everything other than dinner in room. Hamburger was way over done, couldn't eat it

Reviewed on 28 Nov 2025

The Carolina Inn, a Destination by Hyatt Hotel

211 Pittsboro Street Chapel Hill NC

16 min drive from Duke University

Stay at this business-friendly hotel in Chapel Hill. Enjoy free Wi-Fi, breakfast (surcharge) and a free local area shuttle. Our guests praise the helpful staff ...

9.6/10 Exceptional! (1,002 reviews)

Fantastic orher than extremely small room size, but still worth it.❤️

Reviewed on 23 Nov 2025

The Mayton

301 S Academy St Cary NC

37 min drive from Duke University

Stay at this 4-star boutique hotel in Cary. Enjoy free Wi-Fi, free parking and breakfast (surcharge). Our guests praise the helpful staff in their reviews. Popular ...

9.4/10 Exceptional! (711 reviews)

New showers, better noise machine in room, excellent front desk at check in

Reviewed on 21 Nov 2025

See all 4,636 properties in Eastern Piedmont

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.