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Top Luxury Eastern Piedmont Hotels

The Umstead Hotel and Spa

100 Woodland Pond Dr Cary NC

29 min drive from Duke University

Stay at this luxury resort in Cary. Enjoy free Wi-Fi, free parking and an outdoor pool. Our guests praise the helpful staff in their reviews. Popular attractions ...

9.4/10 Exceptional! (724 reviews)

Great property: However, both the restaurant and guest attire was not congruent with a what a 5- start restaurant should be. Portions were nonexistent and after spending $360 for dinner I left the table starving; not to mention, allowing jeans and t-shirts for "fine dining" is embarrassing. Needless ...

Reviewed on 11 Jan 2026

The Carolina Inn, a Destination by Hyatt Hotel

211 Pittsboro Street Chapel Hill NC

16 min drive from Duke University

Stay at this business-friendly hotel in Chapel Hill. Enjoy free Wi-Fi, breakfast (surcharge) and a free local area shuttle. Our guests praise the helpful staff ...

9.4/10 Exceptional! (1,000 reviews)

Awesomr

Reviewed on 13 Jan 2026

The Mayton

301 S Academy St Cary NC

37 min drive from Duke University

Stay at this 4-star boutique hotel in Cary. Enjoy free Wi-Fi, free parking and breakfast (surcharge). Our guests praise the helpful staff in their reviews. Popular ...

9.4/10 Exceptional! (728 reviews)

Great vibe — elegant and cozy (but not stuffy). The hotel location drew us and did not disappoint. The Downtown Cary Park is easily accessible! Also walked to restaurants a few blocks away.

Reviewed on 8 Jan 2026

See all 4,741 properties in Eastern Piedmont

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.