Upstate South Carolina Luxury Holidays
Book a Hotel + Flight or Car together to unlock savings
Photo by South Carolina Department of Parks, Recreation & Tourism
- Plan, book, travel with confidence
Better together
Save up to NZ$616 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place
Top Luxury Upstate South Carolina Hotels
The Westin Poinsett Greenville
120 South Main St, Greenville, SC
Stay at this 4-star business-friendly hotel in Greenville. Enjoy breakfast (surcharge), a free airport shuttle, and 24-hour room service. Our guests praise the ...
9.2/10 Wonderful! (1,000 reviews)
"Amazing. The staff was very attentive to our needs."
Reviewed on 1 Jul. 2025
Hyatt Regency Greenville
220 N Main St, Greenville, SC
Book a stay at this business-friendly hotel in Greenville. Enjoy free WiFi, an outdoor pool, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.6/10 Excellent! (1,004 reviews)
"We had a great time! The facility was nice, and the staff—except for security—were very kind and helpful. My kids and I truly enjoyed our stay, especially being within walking distance of everything including downtown Greenville. There was a bridge tournament and a few baseball teams in town for ..."
Reviewed on 4 Jul. 2025
Sleep Inn at Greenville Convention Cente
231 N Pleasantburg Dr, Greenville, SC
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
7.8/10 Good! (984 reviews)
"👍"
Reviewed on 20 Jun. 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.