Upstate South Carolina Luxury Holidays 2026

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Top Luxury Upstate South Carolina Hotels

The Westin Poinsett Greenville

120 South Main St Greenville SC

1 hour drive from Clemson University

Stay at this business-friendly hotel in Greenville. Enjoy breakfast (surcharge), a free airport shuttle and 24-hour room service. Our guests praise the helpful ...

Hyatt Regency Greenville

220 N Main St Greenville SC

1 hour drive from Clemson University

Stay at this business-friendly hotel in Greenville. Enjoy free Wi-Fi, an outdoor pool and 2 restaurants. Our guests praise the helpful staff and the clean rooms ...

Sleep Inn at Greenville Convention Cente

231 N Pleasantburg Dr Greenville SC

1 hour drive from Clemson University

Stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff in their reviews. ...

8/10 Very good! (1,000 reviews)

"Super nice and affordable! I run back and forth to the hospital, was easy to get to without fighting a lot of traffic. Room was fantastic! The free coffee/tea 24 hours was a blessing! I felt safe as you are anywhere now’s days. Will rebook"

Reviewed on 30 Sept 2026

See all 3,083 properties in Upstate South Carolina

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.