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Top Luxury Upstate South Carolina Hotels

The Westin Poinsett Greenville

120 South Main St Greenville SC

1 hour drive from Clemson University

Stay at this business-friendly hotel in Greenville. Enjoy breakfast (surcharge), a free airport shuttle and 24-hour room service. Our guests praise the helpful ...

9.2/10 Wonderful! (1,001 reviews)

The hotel has an understated elegance - historical, lovely, but not stuffy or “over the top.” We stayed in a junior suite which was generously sized and had a very comfortable sofa and arm chair. One of the things we enjoyed most was the piano music every evening at 5:30, except for Sundays. Very ...

Reviewed on 30 Apr 2026

Hyatt Regency Greenville

220 N Main St Greenville SC

1 hour drive from Clemson University

Stay at this business-friendly hotel in Greenville. Enjoy free Wi-Fi, an outdoor pool and 2 restaurants. Our guests praise the helpful staff and the clean rooms ...

8.8/10 Excellent! (1,002 reviews)

Took forever at the front desk and we were the only people up there. Also, the beds were so horribly noisy. If you rolled over in one of the queen beds in the middle of the night, it was so loud it woke up the person in the other bed.

Reviewed on 29 Apr 2026

Sleep Inn at Greenville Convention Cente

231 N Pleasantburg Dr Greenville SC

1 hour drive from Clemson University

Stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff in their reviews. ...

8/10 Very Good! (1,000 reviews)

far price for the area.

Reviewed on 29 Apr 2026

See all 2,984 properties in Upstate South Carolina

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.