Photo by RVLuckyorWhat

Plan, book, travel with confidence
Better together
Save up to NZ$2,400 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Luxury Upstate South Carolina Hotels

The Westin Poinsett Greenville

120 South Main St Greenville SC

1 hour drive from Clemson University

Stay at this business-friendly hotel in Greenville. Enjoy breakfast (surcharge), a free airport shuttle and 24-hour room service. Our guests praise the helpful ...

9.4/10 Exceptional! (1,000 reviews)

"Always our go to place to stay in Greenville,SC. Never disappointed"

Reviewed on 14 June 2026

Hyatt Regency Greenville

220 N Main St Greenville SC

1 hour drive from Clemson University

Stay at this business-friendly hotel in Greenville. Enjoy free Wi-Fi, an outdoor pool and 2 restaurants. Our guests praise the helpful staff and the clean rooms ...

8.8/10 Excellent! (1,003 reviews)

"Shower was scalding hot. Went to front desk, employee acted like we were bothering her but said she would let maintenance know. Shower still scalding next am. Floor in bathroom and next to bed was VERY slippery. Did not enjoy my stay and would not go back in future."

Reviewed on 24 June 2026

Sleep Inn at Greenville Convention Cente

231 N Pleasantburg Dr Greenville SC

1 hour drive from Clemson University

Stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff in their reviews. ...

8/10 Very good! (1,000 reviews)

"Staff and location was great for our needs. Hotel was under renovation, but still quiet during our stay."

Reviewed on 17 June 2026

See all 3,017 properties in Upstate South Carolina

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.