Photo by Visit Greenville, South Carolina

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Top Luxury Upstate South Carolina Hotels

The Westin Poinsett Greenville

120 South Main St Greenville SC

1 hour drive from Clemson University

Stay at this business-friendly hotel in Greenville. Enjoy breakfast (surcharge), a free airport shuttle and 24-hour room service. Our guests praise the helpful ...

9.2/10 Wonderful! (1,003 reviews)

Easy check in and rooms were clean. The hotel has an old charm to it and is in a great location.

Reviewed on 24 Nov 2025

Hyatt Regency Greenville

220 N Main St Greenville SC

1 hour drive from Clemson University

Stay at this business-friendly hotel in Greenville. Enjoy free Wi-Fi, an outdoor pool and breakfast (surcharge). Our guests praise the helpful staff and the ...

8.6/10 Excellent! (1,004 reviews)

They did a wonderful job everything was great!!!

Reviewed on 24 Nov 2025

Sleep Inn at Greenville Convention Cente

231 N Pleasantburg Dr Greenville SC

1 hour drive from Clemson University

Stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff in their reviews. ...

7.8/10 Good! (1,009 reviews)

Location was very convenient for me. Hotel was quiet. I would stay here again!

Reviewed on 28 Nov 2025

See all 2,897 properties in Upstate South Carolina

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.