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Top Luxury Upstate South Carolina Hotels

The Westin Poinsett Greenville

120 South Main St Greenville SC

1 hour drive from Clemson University

Stay at this business-friendly hotel in Greenville. Enjoy breakfast (surcharge), a free airport shuttle and 24-hour room service. Our guests praise the helpful ...

9.2/10 Wonderful! (1,003 reviews)

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Reviewed on 18 Jan 2026

Hyatt Regency Greenville

220 N Main St Greenville SC

1 hour drive from Clemson University

Stay at this business-friendly hotel in Greenville. Enjoy free Wi-Fi, an outdoor pool and breakfast (surcharge). Our guests praise the helpful staff and the ...

8.6/10 Excellent! (1,006 reviews)

Room was clean for the most part. The couch had some things on it, other than that, great check in, great bar and bartenders and amazing looking lobby.

Reviewed on 17 Jan 2026

Sleep Inn at Greenville Convention Cente

231 N Pleasantburg Dr Greenville SC

1 hour drive from Clemson University

Stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff in their reviews. ...

7.8/10 Good! (1,001 reviews)

Everything was ok , had a deposit to pay inwhich all that should have been up front but other than that , cool

Reviewed on 6 Dec 2025

See all 2,937 properties in Upstate South Carolina

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.