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Top Honeymoon Southern Minnesota Hotels

Alexander Mansion Bed and Breakfast

274 East Broadway Winona MN

2 hours drive from Mayo Clinic

Stay at this B&B in Winona. Enjoy free parking, a business centre and daily housekeeping. Popular attractions Winona Arts Center and Watkins Heritage Museum ...

9.8/10 Exceptional! (518 reviews)

"A beautiful, historic bed & breakfast right in the heart of Winona and close to downtown. This is an incredible house and restoration effort. Old radios in almost every room, in incredible details, and one of the kindest hosts I’ve met. Learned a lot about the history of the building when I arrived ..."

Reviewed on 23 June 2026

Residence Inn by Marriott Rochester Mayo Clinic Area

441 W Center St Nw Rochester MN

4 min walk from Mayo Clinic

Stay at this hotel in Rochester. Enjoy free breakfast, free Wi-Fi and a rooftop terrace. Our guests praise the helpful staff in their reviews. Popular attractions ...

8.6/10 Excellent! (209 reviews)

"Mayo Clinic in Rochester Minnesota is impressive. We were able to walk from our hotel through a pedestrian tunnel system to get to the hospital with access to other clinic buildings, restaurants and shopping. Very convenient for patients and families during the harsh Minnesota winters.I’m"

Reviewed on 26 May 2026

St James Hotel, a Historic Hotel of America

406 Main St. Red Wing MN

2 hours drive from Mayo Clinic

Stay at this spa hotel in Red Wing. Enjoy free Wi-Fi, free parking and a full-service spa. Our guests praise the helpful staff and the comfy rooms in their reviews. ...

9.2/10 Wonderful! (1,003 reviews)

"Nice"

Reviewed on 21 June 2026

See all 1,176 properties in Southern Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.