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Top Honeymoon Southern Minnesota Hotels

Alexander Mansion Bed and Breakfast

274 East Broadway Winona MN

2 hours drive from Mayo Clinic

Stay at this B&B in Winona. Enjoy free breakfast, free parking and a business centre. Popular attractions Watkins Heritage Museum and Polish Cultural Institute ...

10/10 Exceptional! (364 reviews)

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Reviewed on 8 Dec 2025

Residence Inn by Marriott Rochester Mayo Clinic Area

441 W Center St Nw Rochester MN

4 min walk from Mayo Clinic

Stay at this hotel in Rochester. Enjoy free breakfast, free Wi-Fi and a rooftop terrace. Our guests praise the helpful staff in their reviews. Popular attractions ...

8.4/10 Very Good! (199 reviews)

Breakfast great and staff very helpful.

Reviewed on 3 Oct 2025

St James Hotel, a Historic Hotel of America

406 Main St. Red Wing MN

2 hours drive from Mayo Clinic

Stay at this 3.5-star spa hotel in Red Wing. Enjoy free Wi-Fi, free parking and a full-service spa. Our guests praise the helpful staff and the comfy rooms in ...

9.2/10 Wonderful! (1,002 reviews)

Lovely room, great restaurant on site, free parking, nice staff.

Reviewed on 7 Dec 2025

See all 1,196 properties in Southern Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.