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Top Honeymoon Southern Minnesota Hotels

Alexander Mansion Bed and Breakfast

274 East Broadway Winona MN

2 hours drive from Mayo Clinic

Stay at this B&B in Winona. Enjoy free parking, a business centre and daily housekeeping. Popular attractions Winona Arts Center and Watkins Heritage Museum ...

9.8/10 Exceptional! (564 reviews)

"Wonderful host Richard and the beautiful home"

Reviewed on 2 Nov 2026

Residence Inn by Marriott Rochester Mayo Clinic Area

441 W Center St Nw Rochester MN

4 min walk from Mayo Clinic

Stay at this hotel in Rochester. Enjoy free breakfast, free Wi-Fi and a rooftop terrace. Our guests praise the helpful staff in their reviews. Popular attractions ...

8.6/10 Excellent! (213 reviews)

"Room was clean but the bed sheets should be replaced."

Reviewed on 26 Oct 2026

St James Hotel, a Historic Hotel of America

406 Main St. Red Wing MN

2 hours drive from Mayo Clinic

Stay at this spa hotel in Red Wing. Enjoy free Wi-Fi, free parking and a full-service spa. Our guests praise the helpful staff and the comfy rooms in their reviews. ...

9.2/10 Wonderful! (1,005 reviews)

"Great stay. The room was fantastic, we did room service for supper something I never do. It was at our door in no time after ordering. The food was very reasonable and very satisfying. If or looking for a quick getaway to Red Wing you can't beat the St James."

Reviewed on 6 Nov 2026

See all 1,247 properties in Southern Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.