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Top Honeymoon Southern Minnesota Hotels

Alexander Mansion Bed and Breakfast

274 East Broadway Winona MN

2 hours drive from Mayo Clinic

Stay at this B&B in Winona. Enjoy free breakfast, free parking and a business centre. Popular attractions Watkins Heritage Museum and Polish Cultural Institute ...

10/10 Exceptional! (370 reviews)

Room great. Staff great. Guests all had nice conversations at breakfast which was also great. History of house was very interesting.

Reviewed on 31 Jan 2026

Residence Inn by Marriott Rochester Mayo Clinic Area

441 W Center St Nw Rochester MN

4 min walk from Mayo Clinic

Stay at this hotel in Rochester. Enjoy free breakfast, free Wi-Fi and a rooftop terrace. Our guests praise the helpful staff in their reviews. Popular attractions ...

8.4/10 Very Good! (202 reviews)

Wonderful room, staff, breakfast, and location! Thank you so much!

Reviewed on 28 Jan 2026

St James Hotel, a Historic Hotel of America

406 Main St. Red Wing MN

2 hours drive from Mayo Clinic

Stay at this 3.5-star spa hotel in Red Wing. Enjoy free Wi-Fi, free parking and a full-service spa. Our guests praise the helpful staff and the comfy rooms in ...

9.2/10 Wonderful! (1,003 reviews)

The room and linens were pristine. Front desk staff were available and helpful. The hotel food was very good. A lovely small town

Reviewed on 6 Feb 2026

See all 1,199 properties in Southern Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.