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Top Honeymoon Eastern Piedmont Hotels

The Mayton

301 S Academy St Cary NC

37 min drive from Duke University

Stay at this boutique hotel in Cary. Enjoy free Wi-Fi, free parking and breakfast (surcharge). Our guests praise the helpful staff in their reviews. Popular ...

9.4/10 Exceptional! (756 reviews)

"Welcoming"

Reviewed on 18 May 2026

The Umstead Hotel and Spa

100 Woodland Pond Dr Cary NC

29 min drive from Duke University

Stay at this luxury resort in Cary. Enjoy free Wi-Fi, free parking and an outdoor pool. Our guests praise the helpful staff in their reviews. Popular attractions ...

9.6/10 Exceptional! (769 reviews)

"No comments property was great."

Reviewed on 16 May 2026

21c Museum Hotel Durham

111 North Corcoran Street Durham NC

10 min walk from Duke University

Stay at this hotel in Durham. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the helpful staff in their reviews. Popular attractions ...

8.4/10 Very Good! (1,016 reviews)

"The hotel was great overall, cool artwork"

Reviewed on 18 May 2026

See all 4,920 properties in Eastern Piedmont

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.