Photo by Visit Greenville, South Carolina

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Top Beach Upstate South Carolina Hotels

😎Anchors Down Lakeside Retreat 15 min to Clemson🏈 Dock, Padle boat, Kayaks

Seneca SC

21 min drive from Clemson University

Stay at this beach holiday home in Seneca. Enjoy free Wi-Fi, a beach locale and a garden. Popular attractions Friendship Recreaction Area and Cross Creek Plantation ...

10/10 Exceptional! (198 reviews)

Amazing home.....generous host

Reviewed on 9 Nov 2025

Quality Inn Clinton - Laurens I-26

105 Trade St Clinton SC

3 hours drive from Clemson University

Stay at this business-friendly hotel in Clinton. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff in their reviews. Popular ...

7.2/10 Good! (498 reviews)

Staff is always good and rooms are clean and comfortable. Thank you!

Reviewed on 3 Nov 2025

Hampton Inn & Suites Spartanburg-I-26-Westgate Mall

801 Spartan Blvd Spartanburg SC

2 hours drive from Clemson University

Stay at this hotel in Spartanburg. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff in their reviews. Popular attractions ...

8.6/10 Excellent! (969 reviews)

Clean rooms and lobby …

Reviewed on 14 Nov 2025

See all 2,891 properties in Upstate South Carolina

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.