Search Santa Cruz hotels

Start date: Check-in selected.
End date: Check-out
    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
7 Sept - 8 Sept
Tomorrow
8 Sept - 9 Sept
Next weekend
12 Sept - 14 Sept
In two weeks
19 Sept - 21 Sept

Filter by

Guest rating
Guest rating
Star rating

Top hotels and accommodation in Santa Cruz

Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Santa Cruz Hotel Reviews

More cheap accommodation in Santa Cruz

More cheap accommodation in Santa Cruz

Hotel La Casona

Hotel La Casona

Avenida Fitzcarrald 147, Iquitos, Loreto
The price is NZ$76 per night from 8 Sept to 9 Sept
NZ$76
8 Sept - 9 Sept

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Frequently asked questions

If I need to cancel my hotel reservation in Santa Cruz, will I receive a refund?

Yes, you'll find most hotel reservations are fully refundable if cancelled prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your arrival date. If you have a reservation that's non-refundable, you may still be able to cancel and get a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in Santa Cruz.

What should I see while I'm in Santa Cruz?

The picturesque setting of Pacaya-Samiria National Reserve and Huallaga River exemplify the area's natural beauty. Take a look at what more there is to see and do in Expedia's Santa Cruz guide.

What's the seasonal weather like in Santa Cruz?

The hottest months are usually September and October, with an average temperature of 26°C, while the coldest months are July and June, with an average of 25°C. The rainiest months in Santa Cruz are March, April, February and May, with each month seeing an average of 337 mm of rainfall.