The best area to stay in Rio Negro is typically in the vicinity of the town centre, as this provides the most convenient access to local amenities and touring options for the Pantanal.
The town centre isn't large, so staying anywhere within a short walk of the main square, Praça da Matriz, will put you in a good position. You'll find the local church, some small shops, and places to eat here. The roads are generally quiet, and it's easy to navigate on foot. This area is the primary hub for arranging local activities, particularly for those looking to explore the Pantanal ecosystem.
Solo travellers often appreciate the ease of finding tour operators and guides directly from the town centre. Many guesthouses and small hotels in this area can assist with booking excursions, such as wildlife spotting trips, fishing expeditions, or horse riding tours into the Pantanal. It's a practical base for organising adventures and meeting fellow travellers.
For couples, staying in the town centre offers a comfortable and practical base after a day of exploring. You'll have convenient access to local eateries and the ability to relax in a peaceful setting.