Best Western Hotels in Northeast Missouri
Missouri
United States of America
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A large eye sculpture in a park surrounded by trees.

Best Western in Northeast Missouri from NZ$139

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your current months are November, 2026 and December, 2026.

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Our top choices for Northeast Missouri Best Western

A modern living area with a sofa, armchairs, a coffee table, and a kitchen in the background.

A modern lobby with a reception desk, seating area, and a fireplace.

A large indoor pool with clear glass walls, a tiled edge, and a seating area with chairs and tables.

A modern living room with a sectional sofa, a round coffee table, and large windows offering a view of the city.

1. Best Western St. Louis Inn

Best Western St. Louis Inn

2.5 star property

St. Louis

8.4 out of 10, Very good, (1,208 reviews)

8.4/10

Very good

(1,208 reviews)

"Clean rooms good breakfast."

Susan

The price is NZ$140

NZ$140

includes taxes & fees

16 Nov - 17 Nov

Best Western St. Louis Inn

A spacious lobby with multiple seating areas, a central coffee table, and artwork on the walls.

A hotel with multiple floors, a prominent 'Best Western' sign, and a parking area with several cars.

A hotel room with two beds, a nightstand with a lamp, a painting on the wall, and a window with curtains.

A bar area with stools, a counter with bottles, and a dartboard.

2. Best Western St. Louis-Kirkwood Route 66

Best Western St. Louis-Kirkwood Route 66

3.5 star property

Kirkwood

8.2 out of 10, Very good, (1,564 reviews)

8.2/10

Very good

(1,564 reviews)

"Great stay, recommended"

Christopher

The price is NZ$192

NZ$192

includes taxes & fees

8 Nov - 9 Nov

Best Western St. Louis-Kirkwood Route 66

A hotel room with a large bed, a separate bathroom with a bathtub, and a desk with a chair.

A spacious hotel lobby with a central wooden table, seating, a treadmill, and a large potted plant.

A hotel kitchen with a buffet setup, including a coffee station and various food items.

A multi-level indoor pool area with a clear pool, multiple balconies, and a covered seating area.

3. Best Western On The River

Best Western On The River

2.5 star property

Hannibal

8.8 out of 10, Excellent, (1,006 reviews)

8.8/10

Excellent

(1,006 reviews)

"Location was great!"

Rob

The price is NZ$208

NZ$208

includes taxes & fees

17 Nov - 18 Nov

Best Western On The River

A hotel with a modern design, featuring a covered entrance and multiple windows.

A hotel lobby with a reception desk, seating area, and artwork on the walls.

A modern living room with grey sofas, a coffee table, and a TV mounted on the wall.

A hotel room with a bed, a sofa, a desk, and a coffee table.

4. Best Western St. Louis Airport North Hotel & Suites

Best Western St. Louis Airport North Hotel & Suites

2.5 star property

Hazelwood

7.4 out of 10, Good, (1,001 reviews)

7.4/10

Good

(1,001 reviews)

"Decent stay , would stay again ."

Taylor

The price is NZ$176

NZ$176

includes taxes & fees

15 Nov - 16 Nov

Best Western St. Louis Airport North Hotel & Suites

A hotel room with a large white bathtub, a bed with a brown blanket, a nightstand with a lamp, and a framed picture on the wall.

A living room with beige sofas, a coffee table, and a flat-screen TV mounted on the wall.

A lobby with a sofa set, a coffee table, a lamp, and a vase of flowers.

An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.

5. Best Western Teal Lake Inn

Best Western Teal Lake Inn

2.5 star property

Mexico

8.4 out of 10, Very good, (573 reviews)

8.4/10

Very good

(573 reviews)

"Property was close to all needed businesses"

Elizabeth

The price is NZ$187

NZ$187

includes taxes & fees

8 Nov - 9 Nov

Best Western Teal Lake Inn

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Top Northeast Missouri Hotel Reviews

An indoor swimming pool with a view of the outside, a sign reading 'Depot Inn,' and a 'RAILROAD CROSSING' sign on the wall.

A bedroom with a four-poster bed, a bedside table with a lamp, a desk with a telephone, and a bathroom with a bathtub and a hanging plant.

A hotel lobby with a reception desk, seating area, and a sign for the general store.

A living room with a flat-screen TV, fireplace, and a couch with pillows.

Depot Inn and Suites

La Plata

10/10 Excellent

Wonderful place for anyone with an interest in trains. Photos and memorabilia made the lobby and hallways like a museum. Staff were friendly and courteous. Room was comfortable. Breakfast was a point up on typical motel fare.

Robert

Reviewed August 12, 2025Reviewed August 12, 2025

Depot Inn and Suites

A modern lobby with orange seating, a flat-screen TV, and a stone accent wall.

A spacious lobby with a large sectional sofa, a reception desk, and a bar area.

A hotel pool area with a hot tub, lounge chairs, and a 'No Diving Allowed' sign.

A hotel room with two beds, a headboard, bedside lamps, a clock, and a window with curtains.

Drury Plaza Hotel St. Louis St. Charles

St. Charles

10/10 Excellent

Good all round hotel. Clean, friendly and welcoming

Samuel

Reviewed January 27, 2026Reviewed January 27, 2026

Drury Plaza Hotel St. Louis St. Charles

A spacious lobby with a high ceiling, a reception desk, seating areas, and a staircase leading to an upper level.

A Holiday Inn Express hotel with a modern design, featuring a covered entrance and multiple windows.

A modern lobby with a reception desk, seating area, and a dining section.

A hotel room with two beds, a desk, a blue sofa, and a TV.

Holiday Inn Express & Suites St Peters by IHG

St. Peters

8/10 Good

Comfortable and clean.

Mark

Reviewed October 11, 2025Reviewed October 11, 2025

Holiday Inn Express & Suites St Peters by IHG

A spacious lobby with modern seating, a reception desk, and large windows offering views of the parking area.

A spacious indoor area with a high ceiling and large windows, featuring multiple seating areas with sofas and chairs, and a visible outdoor view through the windows.

A spacious indoor area with multiple wooden tables and chairs, large windows, and a high ceiling with exposed beams.

A hotel room with a bed, a desk, a television, and a lamp.

Pear Tree Inn St. Louis Airport

St. Ann

10/10 Excellent

Everything is well done. Such a convenient location.

Shayne

Reviewed February 10, 2024Reviewed February 10, 2024

Pear Tree Inn St. Louis Airport

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Best Western in Northeast Missouri from NZ$139

Change your mind

Treat yourself

Be picky

Check prices for these dates

Our top choices for Northeast Missouri Best Western

1. Best Western St. Louis Inn

2. Best Western St. Louis-Kirkwood Route 66

3. Best Western On The River

4. Best Western St. Louis Airport North Hotel & Suites

5. Best Western Teal Lake Inn

Top Northeast Missouri Hotel Reviews

Depot Inn and Suites

10/10 Excellent

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