Mississippi County Holidays

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Our pick of the best Mississippi County Hotel Deals

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

2 out of 5
310 S Story St Charleston MO
Fully refundableReserve now, pay when you stay
The price is NZ$118 per night from 22 Jan to 23 Jan
NZ$118
22 Jan - 23 Jan
includes taxes & fees
6.6/10 (620 reviews)
Thank you

Reviewed on 7 Nov 2025

Super 8 by Wyndham Charleston/Sikeston East MO
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
The price is NZ$178 per night from 25 Jan to 26 Jan
NZ$178
25 Jan - 26 Jan
includes taxes & fees
9.4/10 Exceptional! (1,005 reviews)
As always it was a perfect visit

Reviewed on 19 Jan 2026

Drury Inn & Suites Sikeston, MO
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
Fully refundableReserve now, pay when you stay
The price is NZ$207 per night from 20 Feb to 21 Feb
NZ$207
20 Feb - 21 Feb
includes taxes & fees
8.8/10 Excellent! (463 reviews)
The room was very clean and nicely appointed. The continental breakfast was good with hot food items and hard boiled eggs, oatmeal, fruit, etc. Price was reasonable.

Reviewed on 10 Jan 2026

Hampton Inn Sikeston
See all 102 properties in Mississippi County
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Mississippi County holiday package cost?
The most affordable Mississippi County package is , so your dream getaway can become a reality — without spending an arm and a leg. Bundle flights, hotels, car rentals and more to create a package that matches your travelling style.
How do I get a cheap travel package to Mississippi County?
You'll save piles of cash if you bundle your flights, hotels and car rentals into a Mississippi County holiday package. Sometimes cheap means fewer options. But not with Expedia. We offer more than 550 partner airlines and 1 000 000 hotels across the world, so you'll always have plenty of variety to choose from. Want to save even more? Add some interesting activities to your package deal to unlock even more bargains! After all, travel is about more than simply getting to your destination.
What are the top hotels in Mississippi County?
East Prairie is one destination that most visitors to Mississippi County put on their itinerary. For a comfortable stay here, look up Super 8 by Wyndham Charleston MO and Quality Inn Charleston I-57.
How far in advance should I book my Mississippi County holiday?
Browse Expedia to compare airfares as soon as possible. In many cases, you can purchase a ticket up to 12 months prior to departure. If you don't see your preferred carrier, or you have to book last minute, fear not. Cheap fares to Mississippi County occasionally appear just weeks before the date of departure.
What does an Expedia Mississippi County travel package include?
That depends on what you're looking for. If you're travelling alone, you might decide to combine hotels and flights. Bringing the whole crew to Mississippi County? A travel package including rental cars, flights and hotels might be a better fit. Expedia gives you the flexibility to build your own travel package.
What should I know before booking a Mississippi County travel package?
You'll enjoy amazing savings when you combine your flights, hotels and rental cars into a package. Plus, booking everything together will make your trip planning easier. So why waste your money or time? Whether you're organising a luxury romantic escape or a budget solo adventure, explore our holiday packages today.
Can I choose my airline with a Mississippi County Expedia holiday package?
Yes — that's the beauty of an Expedia package. You're the boss! We have access to more than 550 airline partners around the world, so you have loads of choice when organising your Mississippi County adventure.
If I'm not able to travel, can I cancel my Mississippi County holiday package?
Yes, you can. We totally understand that even the best-laid plans can fail, so we're happy to help if you have to make changes to your Mississippi County holiday package. It may be possible to cancel or amend your itinerary at no cost if you've booked within 24 hours. Your airline, hotel or car rental company may impose a fee if your booking was made more than 24 hours ago. Head to our Customer Service Portal for further information. Also, be sure to check your itinerary for the nitty-gritty on change fees.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.