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Our top choices for Mesopotamia hotels

To Spiti tis Sofias

To Spiti tis Sofias
Kastoria
10.0 out of 10, Exceptional, (1)
Elegant guesthouse offering complimentary WiFi and parking near Kastoria Lake and Aquarium. Daily housekeeping ensures a tidy retreat while you explore local attractions. Just 18 minutes from Aristoteles Airport for convenient travel.

"Tout simplement le meilleur de notre voyage en Grèce. Simple mais tellement mieux qu'ailleurs. Accueil parfait, chambre confortable et petit déjeuner de roi. Je reviendrais à 100% si je passe dans le coin. "
France
Anonymous traveller
The price is NZ$132
includes taxes & fees
20 Jan - 21 Jan 2026
To Spiti tis Sofias

Guesthouse Monopati

Guesthouse Monopati
Amyntaio
10.0 out of 10, Exceptional, (3)
Set near Moni Panagias Monastery and Arcturos Bear Sanctuary, this charming guesthouse offers free breakfast and WiFi. After exploring nearby attractions, enjoy lunch or dinner at the on-site restaurant Monopati while daily housekeeping ensures a comfortable stay.
Guesthouse Monopati

Limneon Resort & Spa

Limneon Resort & Spa
4.0 star property
Kastoria
9.2 out of 10, Wonderful, (197)
Embrace tranquility at this Kastoria retreat offering 3 restaurants serving Greek cuisine at Cherry Bar-Restaurant. Pamper yourself with hot stone massages at the spa, then relax at 2 bars/lounges after exploring the nearby Neolithic Lakeside Settlement.

"Wonderful stay. "
Canada
Konstantinos
The price is NZ$192
includes taxes & fees
12 Jan - 13 Jan 2026
Limneon Resort & Spa

Kyknos De Luxe Hotel

Kyknos De Luxe Hotel
Kastoria
10.0 out of 10, Exceptional, (43)
Experience comfort at this hotel featuring complimentary WiFi and parking. Near Folklore and Byzantine Museums, it offers 24-hour service. Kastoria Airport is just a 20-minute drive away.

"Very nice clean, very polite staff and great breakfast!"
United States
Vasilios
The price is NZ$181
includes taxes & fees
22 Jan - 23 Jan 2026
Kyknos De Luxe Hotel

Guest House Ilektra

Guest House Ilektra
Voio
9.6 out of 10, Exceptional, (9)
Scenic mountain retreat in Voio with lush gardens and a welcoming terrace for relaxation. Enjoy convenient amenities including an on-site restaurant, bar, free WiFi and complimentary parking while exploring this charming Greek region.

"Wonderful views, easy to find, spacious rooms, and great hospitality."
United Kingdom
Maria
The price is NZ$119
includes taxes & fees
21 Jan - 22 Jan 2026
Guest House Ilektra

Esperos Palace Luxury & Spa Hotel

Esperos Palace Luxury & Spa Hotel
4.0 star property
Kastoria
9.0 out of 10, Wonderful, (84)
Discover tranquility at this Kastoria spa hotel where indoor swimming and rejuvenating treatments await. Just minutes from the Folklore and Byzantine Museums, enjoy free breakfast, WiFi, and convenient parking after exploring local attractions.

"The hotel is beautiful, large room with balcony. Grate bathroom, comfortable, the dinner is good ,however the breakfast was amazing. "
United States
Michal
Esperos Palace Luxury & Spa Hotel

Chloe Hotel

Chloe Hotel
3.0 star property
Kastoria
10.0 out of 10, Exceptional, (86)
Enjoy free breakfast and parking at this Kastoria hotel with a winery and tennis court. Relax with massages and aromatherapy after exploring nearby Byzantine Museum. Helpful staff, café, and bar create a welcoming Mediterranean atmosphere.

"We enjoyed the stay, friendly staff and nice breakfast "
Australia
Fani
The price is NZ$201
includes taxes & fees
22 Jan - 23 Jan 2026
Chloe Hotel

Calma Hotel & Spa

Calma Hotel & Spa
4.0 star property
Kastoria
9.6 out of 10, Exceptional, (35)
Discover Byzantine treasures near this Kastoria hotel, where a seasonal outdoor pool and spa await. Free breakfast, WiFi, and parking enhance your stay, while poolside bar, fitness centre, and sauna complete the relaxing experience.

"Pleasant stay. Good amenities. Great staff. "
New Zealand
Robert
Calma Hotel & Spa

Guesthouse Vissinokipos

Guesthouse Vissinokipos
Kastoria
9.4 out of 10, Exceptional, (10)
Wake up to free breakfast at this guesthouse, where a lush garden and terrace create a peaceful ambiance. Just moments from Byzantine Museum and Folklore Museum, enjoy drinks at the bar or snacks at the café after exploring historic Kastoria.

"Wonderfull view and very friendly people.the place is avery dpecial artistic decorated.wonderfull weather.nice varieties for breakfast.price was ver good.i recommend it!"
United States
Carmen
Guesthouse Vissinokipos

Anesis Hotel

Anesis Hotel
2.0 star property
Kastoria
9.0 out of 10, Wonderful, (9)
Discover cultural treasures near this welcoming Kastoria hotel, just minutes from the Folklore and Byzantine Museums. Enjoy convenient amenities including 24-hour front desk service and room service throughout your stay.

"Fantastic hotel in the heart of Kastoria. The owners are lovely people, very helpful and made me feel right at home. Will definitely stay there again!"
Canada
Adam
The price is NZ$105
includes taxes & fees
12 Jan - 13 Jan 2026
Anesis Hotel

Andromeda Boutique hotel

Andromeda Boutique hotel
4.0 star property
Kastoria
8.8 out of 10, Excellent, (3)
Andromeda Boutique hotel

The Sunset Haven Kastoria Modern Lake Elegance

The Sunset Haven Kastoria Modern Lake Elegance
Kastoria
The Sunset Haven Kastoria Modern Lake Elegance
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Mesopotamia Hotel Reviews

More cheap accommodation in Mesopotamia

Find out more about Mesopotamia

Top reasons to visit Mesopotamia

  • Outdoor Adventures: Mesopotamia offers a variety of outdoor activities, perfect for nature lovers and thrill-seekers alike.
  • Romantic Getaways: The picturesque setting makes it an ideal destination for couples looking for a romantic escape.
  • Rich Cultural Experiences: Explore fascinating museums and historical landmarks that showcase the region's heritage.
  • Scenic Lakes: Nearby lakes provide stunning views and opportunities for picnics and relaxation.
  • Warm Hospitality: Experience the friendly locals and welcoming atmosphere that enhance your stay.

Find great hotels near Mesopotamia

Discover a range of inviting hotels in Mesopotamia, Western Macedonia, perfect for every traveller's needs. Whether you're seeking a comfortable retreat after a day of adventure or a spa-themed getaway, the best accommodation options cater to both business and leisure visitors. Enjoy top-notch amenities and warm hospitality as you explore this charming region of Greece.

  • Esperos Palace Luxury & Spa Hotel: Nestled a mere 8.0km from Mesopotamia, the Esperos Palace Luxury & Spa Hotel is a sophisticated 4-star retreat. This property caters to those seeking a blend of business and relaxation. Its well-appointed facilities include a Conference Centre and multiple meeting rooms, ideal for corporate travellers. For those looking to unwind, the hotel boasts a full spa offering a range of treatments, including massages and indoor pool access. Enjoy a luxurious escape while still being close to your professional commitments.
  • Hotel Anastassiou: Situated 8.0km from Mesopotamia, Hotel Anastassiou is perfect for the adventurous traveller. This hotel combines business amenities, such as a Business Centre and meeting rooms, with exciting recreational opportunities. Guests can easily access ski lifts and shuttles, making it a fantastic choice for winter sports enthusiasts. Additionally, the surrounding area offers hiking, kayaking, and fishing for those who enjoy the great outdoors. Experience a vibrant blend of business and adventure at this welcoming hotel.
  • Kyknos De Luxe Hotel: Just 8.0km from Mesopotamia, the Kyknos De Luxe Hotel stands as a charming 3.5-star property that emphasises luxury and comfort. Ideal for business travellers, it features essential services and facilities that cater to professional needs. While the hotel provides an elegant atmosphere and attentive service, guests can expect a pleasant stay with easy access to the local attractions. Immerse yourself in a luxurious experience while enjoying the convenience of being close to the area's highlights.

Where to stay in Mesopotamia

Mesopotamia, a charming village in Western Macedonia, Greece, offers a delightful blend of outdoor adventures, romantic settings, and rich cultural experiences. Just a stone's throw away, discover the stunning landscapes and family-friendly atmosphere of Kastoria. Enjoy budget-friendly activities or indulge in luxury while exploring this picturesque region. With its friendly locals and unique charm, your trip to Mesopotamia promises to be an unforgettable journey filled with new discoveries.

  • Kastoria: Nestled in the heart of Western Macedonia, Kastoria is a captivating city renowned for its stunning lakeside views and rich history. The area is particularly popular among outdoor enthusiasts, offering activities such as skiing in nearby mountain ranges and relaxing at local spas. Visitors can explore the city's historic landmarks, including ancient monasteries and museums that showcase its cultural heritage. Peak travel times in September and during the winter months invite a lively atmosphere, making it an ideal destination for adventure-seekers and scenery lovers alike.
  • Árgos Orestikón: Located a mere 9.7km from Mesopotamia, Árgos Orestikón is a vibrant city that immerses visitors in its cultural allure. Known for its archaeological sites and museums, the town is a treasure trove for those interested in history and anthropology. The visitor experience is enriched by the beautiful places of worship that dot the landscape. With a steady flow of tourists peaking in September and the winter months, it's an excellent spot for cultural exploration and discovering the rich tapestry of local traditions.
  • Aposkepos: Aposkepos, a quaint village located 9.7km from Mesopotamia, offers a serene escape into nature. This charming destination sees a moderate influx of visitors, especially during the summer months from July to September. Its picturesque surroundings and tranquil atmosphere make it a perfect retreat for those looking to unwind. Aposkepos is ideal for leisurely walks and enjoying the natural beauty of the region, ensuring a peaceful and rejuvenating vacation experience.

Things to do in Mesopotamia

Mesopotamia offers a delightful blend of outdoor adventures and cultural experiences, making it perfect for a romantic getaway. Enjoy a scenic picnic in lush areas, embark on exciting city tours, or explore holiday parks. For those keen on adventure, river tours provide a unique perspective of the stunning landscape. Embrace the charm of this picturesque location as you immerse yourself in its natural beauty and rich heritage.

Shopping

In Mesopotamia, enjoy shopping at local boutiques and markets for unique gifts. If you're up for a drive, visit the nearby Katerini Shopping Centre, about 19.3km away, offering a mix of international brands and local stores for a delightful shopping experience.

Recreation

Experience serenity at the Thermal Springs of Pozar, where you can soak in natural hot springs surrounded by lush greenery. Enjoy rejuvenating spa treatments and explore nearby hiking trails that offer stunning views of the Macedonian landscape.

Adventure

In Mesopotamia, explore the enchanting trails of Mount Vourinos, perfect for hiking and birdwatching. Experience the thrill of kayaking on the serene Aliakmon River, or visit the picturesque Lake Kastoria for canoeing and cycling amidst stunning landscapes.

Nightlife

In Mesopotamia, the local tavernas come alive with traditional music and dancing, creating a vibrant atmosphere. The nearby cafes offer a relaxed vibe for late-night conversations, while bars serve local wines and spirits, making it an ideal spot for a lively evening out.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Mesopotamia

To save money on your trip to Mesopotamia, consider visiting in March or October to November when accommodation prices drop. Book your hotel about a month in advance or look for last-minute deals on Expedia. Saturdays generally offer the lowest rates, while Thursdays are pricier. Use Expedia’s search tool to filter by budget and sort from lowest to highest price. Combining hotel, flights, and activities into a package can also lead to significant savings, helping you enjoy your stay without breaking the bank.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay in Mesopotamia are March and October to November, where the prices are slightly lower. This is in comparison to April and July to August, where prices are slightly higher.
  • The best time to book a hotel: The cheapest time to book a hotel in Mesopotamia is usually 1 month out from when you are planning to stay, though if you're late to the party, have a look at Expedia's last minute deals - the green banner below the hotel's price indicates a discounted rate.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay in Mesopotamia is Saturday. The most expensive day to stay in Mesopotamia is Thursday.
  • Find cheap hotels on Expedia: Utilise Expedia’s search tool to refine your preferences, such as your budget, desired location, and the type of accommodation you prefer. To find the best value, make sure to sort the price filter from lowest to highest.
  • Consider bundling your trip: You can save some cash by combining your Mesopotamia hotel booking with your flights and activities through an Expedia package.

Find the best attractions near Mesopotamia

Mesopotamia in Western Macedonia is perfect for outdoor and romantic getaways steeped in culture. Explore nearby lakes, fascinating history museums, and notable landmarks that cater to those seeking rich cultural experiences, stunning scenery, and relaxing beachtime. With plenty of attractions within and around Mesopotamia, you're sure to discover memorable activities and sights that will enhance your holiday adventure.

  • Kastoria Lake: Nestled a mere 8.0km from Mesopotamia, Kastoria Lake offers breathtaking scenery and a romantic atmosphere. Enjoy outdoor activities, stroll along the shore, or relax on the beach while soaking in the stunning views.
  • Folklore Museum of Kastoria: Located 8.0km away, this captivating history museum immerses you in the rich culture of the region. Explore traditional costumes, artefacts, and exhibits that showcase the local heritage and craftsmanship.
  • Taxiarhia of the Metropolis: This landmark, also 8.0km from Mesopotamia, blends trendy and luxury vibes with budget-friendly options. Discover its architectural beauty and enjoy a peaceful atmosphere, perfect for reflection and appreciation.

Best time to go to Mesopotamia

The best time to visit Mesopotamia can depend on the weather and when visitor numbers rise and fall. The hottest average temperature in Mesopotamia falls in August, when visitor numbers are moderately high and weather is sunny with no rain. The coolest average temperature in Mesopotamia falls in January, visitor numbers are moderately low and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January32.5°F (0.3°C)Light RainMostly SunnyModerately LowAverage
February36.1°F (2.3°C)Light RainMostly SunnyModerately LowAverage
March41.7°F (5.4°C)Light RainMostly SunnyAverageSlightly Low
April50.2°F (10.1°C)Light RainMostly SunnyAverageSlightly High
May57.9°F (14.4°C)Light RainMostly SunnyAverageAverage
June66.0°F (18.9°C)No RainMostly SunnyAverageAverage
July72.3°F (22.4°C)No RainSunnyModerately HighSlightly High
August72.5°F (22.5°C)No RainSunnyModerately HighSlightly High
September64.2°F (17.9°C)No RainMostly SunnyModerately HighAverage
October54.1°F (12.3°C)Light RainMostly SunnyAverageSlightly Low
November45.1°F (7.3°C)Light RainMostly SunnyModerately LowSlightly Low
December36.3°F (2.4°C)Light RainMostly SunnyAverageAverage

The nearest major airports for your trip to Mesopotamia

To visit Mesopotamia in Western Macedonia, Greece, you can fly into two major airports. Kozani Airport (KZI-Filippos) is situated 61.2km from Mesopotamia, with nearby hotels like Tselikas, a 3.5-star hotel just 1.6km away, and Anesis Hotel, located 3.2km away. Alternatively, Kastoria Airport (KSO-Aristoteles), 11.3km from Mesopotamia, offers luxurious options such as the 5-star Limneon Resort & Spa, 4.8km away, and Orologopoulos Mansion, 8.0km away. Various transportation services are available, including 24-hour airport shuttles and on-request transfers from these hotels, making access convenient for your stay in the area.

Frequently asked questions

Where is the best place for a stay in Mesopotamia?
To Spiti tis Sofias is one of the top choices for your stay based on our traveller data. This guest house offers free parking and free WiFi. Two other choices for your stay in the area are Limneon Resort & Spa and Hotel Anastassiou. See all available top hotels, or vacation rentals in Mesopotamia.
What are some of the best holiday rentals that Mesopotamia has to offer?
The Sunset Haven Kastoria Modern Lake Elegance: This holiday home rental outside of Mesopotamia offers a BBQ and free WiFi to help you feel comfortable in your new surroundings. See all vacation rentals in Mesopotamia.
If I need to cancel my hotel reservation in Mesopotamia, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If your reservation is non-refundable, you might be able to cancel it and be given a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in Mesopotamia.
What is staying in Mesopotamia like?
Travellers to Mesopotamia will find plenty to explore and enjoy. There are 46 hotels and other accommodation options in the surrounding area. Find out more about Mesopotamia.
What are the top places to visit in Mesopotamia?
Places to visit in the wider area include Kastoria Aquarium, Kastoria Lake and Dragon's Lair. You'll also find Folklore Museum of Kastoria and Neolithic Lakeside Settlement in the area. Take a look at what more there is to see and do in Expedia's Mesopotamia guide.
What's the seasonal weather like in Mesopotamia?
The hottest months are usually August and July, with an average temperature of 20°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Mesopotamia is 707 mm.

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