In the heart of Jeffersonville, Deaconess Guesthouse combines historical charm with modern luxury. Enjoy stunning riverfront views from the front porch and balcony or unwind in the hot tub under starry skies. This spacious retreat boasts indoor gaming zones, a unique dome, fully-equipped kitchens, SMART ROKU TVs in every living room and bedroom.
Reviews
1010 out of 10
Exceptional
Entire home
8 bedrooms6 bathroomsSleeps 24539 sq m
Popular amenities
Hot tub
Dryer
Fireplace
Washer
Kitchen
Parking available
Add dates for prices
About this property
Entire place
You'll have the entire home to yourself and will only share it with other guests in your party.
*** Deaconess Guesthouse — Iconic Luxury Overlooking the Ohio River · Minutes from Louisville and Historic Jeffersonville ***
★ Where Historic Architecture Meets Modern Luxury Deaconess Guesthouse is an extraordinary 1800s landmark estate, originally Jeffersonville’s first public hospital and now meticulously reimagined as a premier riverfront retreat. Restored by Charming Vacation Homes with a focus on craftsmanship, comfort and timeless elegance, this distinguished property blends historic character with boutique-hotel sophistication—all framed by expansive Ohio River views.
Situated just steps from Jeffersonville’s lively riverfront district and minutes from Downtown Louisville and the Bourbon Trail, the estate offers an exceptional setting for guests seeking a stay defined by luxury, convenience and unforgettable surroundings.
★ Designed for Elevated Gatherings and Exceptional Stays Offering 8 designer bedrooms and 6 spa-inspired bathrooms across four private suites, Deaconess Guesthouse accommodates up to 24 guests—ideal for: - Corporate and executive retreats - Multi-family vacations - Wedding parties and milestone celebrations - Holiday gatherings and special events Every room is curated with refined textures, custom artwork, premium furnishings and warm, inviting spaces designed for conversation, connection and relaxation.
★ Signature Features and Luxury Amenities 1. Private Hot Tub and Fire Pit: A serene riverfront escape perfect for unwinding under open skies. 2. Wraparound Porches and Balconies: Enjoy sweeping water views, morning sunrises, and sunset cocktails. 3. Stargazing Dome: A unique retreat for children, creatives, and couples looking for an imaginative hideaway. 4. Ample On-Site Parking: A rare luxury for large groups, corporate stays, and event planners. 5. Unmatched Location with Premier Access 6. Walkable to Downtown Jeffersonville: Boutique shopping, dining, festivals, and seasonal waterfront events. 7. 2.5 Miles to Downtown Louisville: Distilleries, Churchill Downs, museums, concert venues, sports arenas and vibrant nightlife. 8. Outdoor Recreation: Paddleboarding, biking paths, and scenic riverfront activities right outside the property.
★ An Exceptional Riverfront Estate for Memorable Gatherings From evenings by the fire pit to shared moments on the wraparound porch as riverboats drift by, Deaconess Guesthouse provides an atmosphere designed for slowing down, savoring your surroundings, and reconnecting with the people who matter most.
Blending historic charm, modern sophistication, and an unrivaled waterfront setting, this estate offers more than a place to stay—it offers an experience, a gathering place, and a setting where unforgettable memories are made.
★ Now Booking Luxury Stays and Private Events Ideal for: - Executive and team retreats - Multi-family vacations - Weddings, anniversaries, and milestone celebrations - Holiday gatherings and weekend escapes
Reserve your stay at one of the region’s premier luxury estates—where history, elegance, and meaningful experiences come together.
★ CONVENIENT LOCATION The house is centrally located and is within a 10-15 minute Uber/Lyft drive to most locations:
- Big Four Walking Bridge (Connecting KY and IN) - 0.4 miles (2 mins) - Churchill Downs (DERBY) - 7.7 miles (15 mins) - KFC Yum Center - 2.3 miles (7 mins) - Downtown Louisville/ 4th Street Live - 2.4 miles (6 mins) - Waterfront Park - 3.4 miles (9 mins) - Papa Johns Stadium (Cardinal Stadium) - 6.4 miles (11 mins) - University of Louisville - 6.5 miles (12 mins) - Kentucky Fairgrounds - 6.5 miles (10 min) - Kentucky Exposition Center - 6.7 miles (11 mins) - Kentucky Kingdom - 7.4 miles (13 mins) - Highland Festival Grounds - 8.5 miles (12 mins) - Louisville Airport - 8.6 miles (10 mins) - Louisville Mega Cavern - 10.2 miles (19 mins) - UPS Worldport - 11.2 miles (20 mins) - Ford LAP Plant - 10.9 miles (16 mins) - Waverly Hills Sanatorium - 17 miles (30 mins) - Valhalla Golf Club - 19 miles (27 mins)
PROPERTY HIGHLIGHTS ★ Breathtaking Panoramic Views: Wake up to sweeping, cinematic vistas of the Ohio River—where each sunrise paints a new masterpiece. Enjoy effortless access to the vibrant downtowns of Jeffersonville and Louisville, offering boutique shopping, award-winning dining, live entertainment and year-round festivals just moments away. ★ Historic Grandeur, Modern Sophistication: This iconic landmark has been meticulously restored and thoughtfully reimagined. Timeless architecture blends seamlessly with contemporary elegance—designer décor, curated furnishings and preserved historic details create a space that feels both luxurious and unmistakably welcoming.