Beginning of main content

St. Louis 5 stars Hotels

Search Flights

Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

St. Louis Hotels

Search Flight + Hotel

Advanced options

Search 321,000 hotels worldwide.

Get the price guarantee available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.

Featured St. Louis 5 stars Hotels

See all 261 Hotels in St. Louis
Four Seasons Hotel St Louis
Four Seasons Hotel St Louis
999 North Second Street, St. Louis
5.0 out of 5.0
4.8 out of 5 (92 reviews)
Hide review
Good hotel, location has some good/bad points The experience staying at the Four Seasons in St. Louis was great overall. The staff were uniformly helpful and the room excellent. The attached casino is fine if you might want that facility - when I was there the restaurants attached to the casino were only open part-time with one exception, and ...
  5 May 2017



Five Star Hotels & Resorts in St. Louis

Take your trip to the next level and live like a luminary when you use to book a 5 star accommodation in St. Louis, Missouri. Exclusively offering the best of everything, including the biggest rooms, most amazing amenities, and beds so comfortable you’d swear they were clouds, the five star hotels in St. Louis can serve as the setting for some of your life’s most memorable moments.

These hotels are so luxurious, you’ll be pinching yourself the whole time. But this is no dream. Feast on the finest food on the planet, enjoy incredible massages that relax every muscle in your body, and undergo resplendent spa treatments that provide the utmost in rejuvenation when you reserve a room at one of St. Louis 5 star hotels. And since these hotels often have the best views and locations in the area, you’ll have no problem getting to any of the events or attractions that St. Louis is so famous for. When all that matters is enjoying the best accommodation in St. Louis, count on to help you score unbeatable deals and discounts on the top hotels in town.