I stayed at the hotel for a recent conference at the Moscone Center. The location of the hotel was very convenient for this. The hotel itself was well presented and clean. The staff were very friendly and helpful at all times. I stayed in a room at the back of the hotel - having read previous reviews about noise - and this was perfectly quiet. I'd also read some reviews about a musty smell in the hotel, which I did not experience at all. Excellent!
The hotel itself is situated 1 minutes walk to Market Street where most of the shopping is located the convenience itself is a plus. The staff is really fantastic they give guest the feel of home especially for a first time guest of the city their service in my opinion surpass the 5 stars hotel.
As to safety the area in general there are a lot of homeless people asking for money and cigarette you just have to be polite and reject them no need to be mean or aggressive towards them mind you there is also 5 star hotel in the same area but the hotel staff really do their part by not letting non guest to enter the hotel which includes the use of their toilets. I would strongly advice family visitors do not let their children roam about in the nights.
If you need a cab let the front desk know so that they get their regular/trusted cab drivers to service you but as most of the things are nearby the only time you may need the cab is to the airport.