Santa Cruz Island Holidays

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to NZ$2,400 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Santa Cruz Island Holiday

Our pick of the best Santa Cruz Island Hotel Deals

Hotel Fiesta

Hotel Fiesta

3.5 out of 5
Calle Moises Brito y Juan Montalvo Puerto Ayora Galapagos
Fully refundableReserve now, pay when you stay
The price is NZ$267 per night from 11 June to 12 June
NZ$267
11 June - 12 June
9/10 Wonderful! (413 reviews)
"This place was amazing. The pool, hot tub, and bar were top notch, and just what we needed at the end of a long day of activity."

Reviewed on 5 June 2026

Hotel Fiesta
Maidith Galapagos Inn

Maidith Galapagos Inn

3 out of 5
Calle Cucuve #341 y Seymour, Santa Cruz Puerto Ayora Galápagos
The price is NZ$239 per night from 23 June to 24 June
NZ$239
23 June - 24 June
10/10 Exceptional! (142 reviews)
"The Maidith is such a unique hotel. Nico and all the staff were so friendly and helpful. We really loved staying here and will definitely stay here next time we come to the Galápagos Islands."

Reviewed on 8 June 2026

Maidith Galapagos Inn
Hotel el descanso del Guia

Hotel el descanso del Guia

3.5 out of 5
Calle Delfin, Barrio el Mirador Puerto Ayora Galapagos
The price is NZ$114 per night from 15 June to 16 June
NZ$114
15 June - 16 June
8.8/10 Excellent! (208 reviews)
"Nice and clean hotel, nice and professional staff love my staying at el descanso del guía"

Reviewed on 7 June 2026

Hotel el descanso del Guia
See all 225 properties in Santa Cruz Island
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Santa Cruz Island

Playa de los Alemanes

If a restful holiday is part of your travel plans, Playa de los Alemanes might be the perfect place to visit during your trip to Puerto Ayora. While you're here, you can savour the top-notch restaurants.

Playa de los Alemanes

What to do in Santa Cruz Island

Transfer from Santa Cruz Island to San Cristobal Island

Transfer from Santa Cruz Island to San Cristobal Island

NZ$94
per adult
Transfer from Santa Cruz Island to San Cristobal Island
Bay Tour in Santa Cruz - Galapagos Islands

Bay Tour in Santa Cruz - Galapagos Islands

NZ$101
per adult
100% of travellers recommend
Bay Tour in Santa Cruz - Galapagos Islands
Transfer from San Cristobal Island to Santa Cruz Island

Transfer from San Cristobal Island to Santa Cruz Island

NZ$94
per adult
Transfer from San Cristobal Island to Santa Cruz Island
See all activities in Santa Cruz Island

Frequently asked questions

Can I cancel my flight booking to Santa Cruz Island due to COVID-19?
Many airlines now provide more flexibility due to COVID-19. Our convenient Customer Service Portal will help answer most queries about which policies apply to your flight. It's also worth scanning over the terms and conditions of your chosen carrier — preferably before locking in your seat!
What's the best way to find cheap flights to Santa Cruz Island that have flexible change policies?
We know that travel arrangements can change from one day to the next, so choosing a flexible fare with Expedia is always a wise idea. Simply tick the "No change fee" box below the "Flexible change policies" filter. Your low-cost, flexible flight to Santa Cruz Island is only a few clicks away.
What are some of the general tips for travellers to Santa Cruz Island during the COVID-19 outbreak?
The COVID-19 pandemic has brought about big changes to the way we travel. If you're planning an escape to Santa Cruz Island, the following tips will help you navigate this new travelling reality:
  • Research if any travel restrictions apply to your origin and destination before booking your flight. Also check if there are any requirements you'll have to follow on arrival, such as health testing.
  • Wear a face mask even during airport screening. A TSA officer will require you to adjust your mask for identification purposes.
  • You're no longer required to hand your boarding pass (paper or electronic) directly to a TSA officer. Rather, you should position the pass on the reader and then hold it up to allow the agent to visually inspect it.
  • You are now allowed to take one container of hand sanitizer up to 12 oz (350 ml) in your carry-on luggage. This will need to be removed for X-ray scanning.
  • To minimize handling during the screening process, place items such as your phone, wallet and keys into your carry-on instead of the bins.
  • Separate any food you have for screening. Food items often trigger the alarm. Putting them in a clear plastic bag and into a bin reduces the need for a TSA agent to touch and inspect your belongings.

Which airlines fly to Santa Cruz Island?
LATAM Airlines Ecuador runs flights into or near Santa Cruz Island, including 60 that arrive at Seymour Airport (GPS) each month. Choose your holiday dates and then secure your seat early for the best price.
How can I find cheap tickets to Santa Cruz Island?
For the best deal to Santa Cruz Island, book well ahead of time. Also make use of Expedia's "flexible dates" link at the top of your search results. This will display prices for similar time frames. In the last seven days, was the lowest price for a flight to Santa Cruz Island.
How much is a flight to Santa Cruz Island?
If you were flying one way from (), you could've picked up a cheap ticket for in the last seven days. Round-trip flights to Santa Cruz Island ranged from only to during this same period.
What are the most popular airports to fly into in Santa Cruz Island?
Seymour Airport (GPS) is the main entryway for people travelling into and out of Santa Cruz Island. Approximately 95 flights a month touch down at this airport.
When is the cheapest time to fly to Santa Cruz Island?
Departing on a Tuesday, followed by a Monday, is generally the best way to bag the cheapest fare. Avoid the weekends if you can, because Saturday is typically the most expensive day of the week. Spend the cash you saved having a good time in Santa Cruz Island instead!
How much is a plane ticket to Santa Cruz Island?
In the last seven days, plane tickets to Santa Cruz Island fluctuated between and . Prices rise as your travel date nears, so grab a terrific deal today.
Which airlines with flights to Santa Cruz Island employ COVID-19 cleanliness policies?
Like most things, plane travel is looking very different nowadays. Airlines worldwide have adopted a range of measures, including social distancing, to slow the spread of COVID-19. Here are some of them:
  • LATAM Airlines Ecuador - this airline is known for providing passenger masks and cleaning with disinfectant.
  • Avianca - this airline is known for conducting passenger temperature checks and cleaning with disinfectant.

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.